DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and Zfp39

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001100474.2	Gene:	Zfp39 / 303173	RGDID:	1306633	Length:	717	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	133/767 - (17%)
Similarity:	191/767 - (24%)	Gaps:	425/767 - (55%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 EFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDD---HL-IGAHHFKQDE---- 368
            :.:|.||    |.:|...||         |..|:|.:.:.....|   |: :|:|.:||.|
  Rat   313 KLTKHKK----IHKGQKYFT---------CRDCEKTFINTSYHKDQRIHVGVGSHRYKQCENCFH 364

  Fly   369 ---------------------------------------------FPCKQCALRFCHRPLLIKHE 388
                                                         :.|..|...|..:..|.:|:
  Rat   365 QKNQQSVHQSVPKGSKLYEMYQSEQSFSEKPNLRCCQKTRAGYKPYRCNMCGKSFYRKSHLSRHQ 429

  Fly   389 AISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVK 453
            .| |...|.|.|:.|.|.|...|:|..|.|. |.|.:.:.|.:|.|||...|.|..|...|:..|
  Rat   430 RI-HTGERPYGCKECKKAFFHKSSLTIHQRT-HTGEKPYECKKCRKTFYCKSDLNVHHRTHTGEK 492

  Fly   454 PFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF--------CDSTG 510
            |:.|:.|.|.:...|:|..|:::| |.....:|.:|.::|:..::||.|:|.        ||..|
  Rat   493 PYECDECRKTFYSKSHLIIHRKIH-TGDKPYECQECQKTFNRKSNLTVHQKTHTGEKPYECDVCG 556

  Fly   511 PGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFL 575
            ...:|..|::. ||..|....|::          |..
  Rat   557 KTFHRQSHLSM-HQGIHSGEKPYK----------CKE---------------------------- 582

  Fly   576 MFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFL 640
                                                       ||        .||.||
  Rat   583 -------------------------------------------CG--------KAFYQK------ 590

  Fly   641 KGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQD 705
                                                       |||.     ...||.:
  Rat   591 -------------------------------------------SSLS-----RHQRNHT------ 601

  Fly   706 DMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNL 770
                                                  ||.|.....|||              .
  Rat   602 --------------------------------------GDRPYACEECRK--------------T 614

  Fly   771 MLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGG 835
            .||:....:|                        |:||.|..|
  Rat   615 FLHKSSLTVH------------------------QRSHTGYKP---------------------- 633

  Fly   836 ELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIE 900

  Rat   634 ----------------------------------------------------------------- 633

  Fly   901 ALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPC 965
                                              |||:.|.|.|...::||.|.||||||:||.|
  Rat   634 ----------------------------------YSCEECRKTFYSKSHLTVHQRTHTGEKPYEC 664

  Fly   966 KYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |.|.:||...|.|.|| :..|.:|:.|.|:.|.:.|..:::|..|.:.|..|
  Rat   665 KLCRKAFHQKSYLSRH-QITHEREKRFECQECRKRFYHKSSLTVHQRIHLRE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/25 (24%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	36/83 (43%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	15/23 (65%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
Zfp39	NP_001100474.2	KRAB	59..118	CDD:214630
		KRAB	59..98	CDD:279668
		COG5048	296..697	CDD:227381	128/747 (17%)
		C2H2 Zn finger	301..321	CDD:275368	3/11 (27%)
		C2H2 Zn finger	329..348	CDD:275368	4/18 (22%)
		zf-C2H2	410..432	CDD:278523	6/22 (27%)
		C2H2 Zn finger	412..432	CDD:275368	6/20 (30%)
		C2H2 Zn finger	440..460	CDD:275368	8/20 (40%)
		zf-H2C2_2	452..475	CDD:290200	8/23 (35%)
		C2H2 Zn finger	468..488	CDD:275368	8/19 (42%)
		zf-H2C2_2	480..503	CDD:290200	8/22 (36%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	7/24 (29%)
		C2H2 Zn finger	552..572	CDD:275368	7/20 (35%)
		zf-H2C2_2	564..587	CDD:290200	8/112 (7%)
		C2H2 Zn finger	580..600	CDD:275368	11/152 (7%)
		C2H2 Zn finger	608..628	CDD:275368	7/57 (12%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		zf-H2C2_2	648..673	CDD:290200	16/24 (67%)
		C2H2 Zn finger	664..684	CDD:275368	9/20 (45%)
		C2H2 Zn finger	692..712	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000