DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Mecom

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001376211.1	Gene:	Mecom / 294924	RGDID:	1310997	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	1212	Identity:	362/1212 - (29%)
Similarity:	508/1212 - (41%)	Gaps:	341/1212 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PVEGSPPRRDHLDIQDQELLHHPNHFHQQNQRQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRA 127
            |:|..|...|...|.:...||          .|:|..|.  .|.||.:....|......:..|..
  Rat    25 PLEEMPDAEDADGIANAPSLH----------IQEPCSPA--TSSESFTPKEGSPYKAPIYIPDDI 77

  Fly   128 QAEHILQEWVRRREPV-CELDIRDSG------GVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWK 185
                          |: .|.::|:|.      |::.|..::.|.::||:..:......|....|:
  Rat    78 --------------PIPDEFELRESTMPGAGLGIWTKRKIEIGEKFGPYMGEQRSDLKDSSYGWE 128

  Fly   186 AHSRHYN--GWLEPTE-DVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVV- 246
            ......|  ..::.:: ||.:|||.||..  .|..:.||.:......::|.....:..|.|:::
  Rat   129 ILDEFCNVKFCIDASQPDVGSWLKYIRFA--GCYDQHNLVACQINDQIFYRVVADIAPGEELLLF 191

  Fly   247 ---DGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPS--DDRSDR---- 302
               :..|..|:                                       ||.  ::|..|
  Rat   192 MKSEEDPHEPM---------------------------------------APDIHEERQHRCEDC 217

  Fly   303 -----DNGSLYSGDEFSKDKKNS--SLIREGDIDFTDD-ENGFDIR-------CEVCDKVYPDLD 352
                 ....|....:|.....:|  |::.|   |...: |:..|:|       |:.||:|:|||.
  Rat   218 DQLFESKAELADHQKFPCSTPHSAFSMVEE---DLQQNLESESDLREIHGNQDCKECDRVFPDLQ 279

  Fly   353 LLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSK-VFCDPSNLQRH 416
            .|:.|::.  |.::.|:.|.||...|..:..||:|: :||::.:.|.||||:| ||.||||||||
  Rat   280 SLEKHMLS--HTEEREYKCDQCPKAFNWKSNLIRHQ-MSHDSGKHYECENCAKQVFTDPSNLQRH 341

  Fly   417 IRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCR 481
            ||:.|||||.|.||||||||.||||||||:|||||||||.||||.|:|||||||||||||||.||
  Rat   342 IRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCR 406

  Fly   482 MQIKCDKCNQSFSTLTSLTKHKKFCDST---GPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATS 543
            .||||..|.|.|||.:||.||::||:..   ..|.:..|.::          ||
  Rat   407 TQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGIS----------LP----------- 450

  Fly   544 TCPAPPRESSESSSSAAAAAVAAMSTPPNPF-LMFRTAPSF---FPGFPPYGF---PPFLP---- 597
            ..||..:.|..:...|....|....|..:|. |.|.|||.|   |||..|.|.   ||.:|
  Rat   451 GTPAMDKTSMVNMGHANPGLVDYFGTNRHPAGLTFPTAPGFSLSFPGLFPSGLYHRPPLIPASSP 515

  Fly   598 -------------QNPL--HPTNIP------MFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLK 641
                         |:||  ||..:|      ...||:|            ||.  |.| |...|.
  Rat   516 VKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHP------------PVG--DNK-PVELLP 565

  Fly   642 GENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDD 706
            ..:||.:..:|::::......::       |....|.:.|:.|..|::..||..:...|    ::
  Rat   566 ERSSEERPLEKISDQSESSDLDD-------VSTPSGSDLETTSGSDLESDLESDKEKCK----EN 619

  Fly   707 MKQEPERVS----------------------TPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLD 749
            .|...::||                      :.::|.|.....:..|.:....|:...|..|.:.
  Rat   620 GKMFKDKVSPLQNLASINNKKEYSNHSVFSASVEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVG 684

  Fly   750 LSICRKRSAG-----SFFTAPAEDNLMLHRFMPRLHEFEAE--RGQPLKMRKSHSSAESSTSQKS 807
            |   :.:..|     |.|..|     ....|...::.|...  |..||||...    ..|..:|.
  Rat   685 L---QDKKVGALPYPSMFPLP-----FFPAFSQSMYPFPDRDLRSLPLKMEPQ----SPSEVKKL 737

  Fly   808 HKGSSPTP----------TPTASPGLTPSPSPPTSAGG---ELSSTSEGGAVPTMAAAAFAADH- 858
            .||||.:|          .|..| |.:..|:.|.::..   :||..|...|..|..... ..:|
  Rat   738 QKGSSESPFDLTTKRKDEKPLTS-GSSKLPATPATSQDQPLDLSMGSRSRASGTKLTEP-RKNHV 800

  Fly   859 ------SALASGP----TLPQTHPTFHPLLLEEIYR---------------------SGFPFLCQ 892
                  |.:.:.|    :|....||  |..::.|||                     .||.|..|
  Rat   801 FGEKKGSNMETRPSSDGSLQHARPT--PFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQ 863

  Fly   893 ---PGGRRGIEAL-----------------------LAGAASAAAPKRPLPPVKFSAGSVVGLKT 931
               |..|..:.|:                       :....|..||...||......|
  Rat   864 FPLPDQRTWMSAIENMAEKLESFSGLKPEASELLQSVPSMFSFRAPPNTLPENLLRKG------- 921

  Fly   932 KDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCEL 996
            |:||:|::|||:||||||||||||||||||||.||||||:||||||||||||||||||:||:|.|
  Rat   922 KERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHL 986

  Fly   997 CDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREE-----------YFDDIRKFMNRVYTP 1050
            |||.||||||||||:||||:  .|...:.:||..:|.|.           ||.:||.|:
  Rat   987 CDRCFGQQTNLDRHLKKHEN--GNMSGTATSSPHSELESAGAILDDKEDAYFTEIRNFI------ 1043

  Fly  1051 NSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNNNSSNISNNNS 1092
                ||.....:.|.:.::.:|    ..:|.:..:..::.||
  Rat  1044 ----GNSNHGSQSPRNMEERMN----GSHFKDEKALATSQNS 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	26/135 (19%)
		C2H2 Zn finger	341..363	CDD:275368	9/21 (43%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	70/88 (80%)
		C2H2 Zn finger	400..421	CDD:275368	17/21 (81%)
		SUF4-like	403..>445	CDD:411020	34/42 (81%)
		C2H2 Zn finger	403..421	CDD:411020	14/18 (78%)
		C2H2 Zn finger	429..449	CDD:275368	17/19 (89%)
		C2H2 Zn finger	457..477	CDD:275368	17/19 (89%)
		C2H2 Zn finger	486..504	CDD:275368	10/17 (59%)
		PTZ00121	<641..>728	CDD:173412	16/108 (15%)
		COG5048	935..>1028	CDD:227381	71/92 (77%)
		zf-C2H2	935..957	CDD:395048	17/21 (81%)
		C2H2 Zn finger	937..957	CDD:275368	16/19 (84%)
		zf-H2C2_2	949..973	CDD:404364	21/23 (91%)
		C2H2 Zn finger	965..986	CDD:275368	19/20 (95%)
		C2H2 Zn finger	994..1014	CDD:275368	16/19 (84%)
Mecom	NP_001376211.1	SET	50..207	CDD:394802	35/213 (16%)
		C2H2 Zn finger	214..263	CDD:275368	9/51 (18%)
		C2H2 Zn finger	268..288	CDD:275368	9/21 (43%)
		zf-H2C2_2	280..304	CDD:404364	7/25 (28%)
		zf-C2H2	294..316	CDD:395048	7/22 (32%)
		C2H2 Zn finger	296..316	CDD:275368	7/20 (35%)
		C2H2 Zn finger	324..346	CDD:275368	17/21 (81%)
		SFP1	<347..399	CDD:227516	44/51 (86%)
		C2H2 Zn finger	354..374	CDD:275368	17/19 (89%)
		zf-C2H2	380..402	CDD:395048	18/21 (86%)
		C2H2 Zn finger	382..402	CDD:275368	17/19 (89%)
		C2H2 Zn finger	411..429	CDD:275368	10/17 (59%)
		PHA00733	881..977	CDD:177301	53/102 (52%)
		zf-C2H2	925..947	CDD:395048	17/21 (81%)
		C2H2 Zn finger	927..947	CDD:275368	16/19 (84%)
		zf-H2C2_2	939..963	CDD:404364	21/23 (91%)
		C2H2 Zn finger	955..976	CDD:275368	19/20 (95%)
		zf-C2H2	982..1004	CDD:395048	17/21 (81%)
		C2H2 Zn finger	984..1004	CDD:275368	16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352691
Domainoid	1	1.000	53	1.000	Domainoid score	I11043
eggNOG	1	0.900	-	-		E33208_3BAJ6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1785
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm45508
orthoMCL	1	0.900	-	-		OOG6_105951
Panther	1	1.100	-	-	LDO	PTHR24393
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2993
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890