DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ham and Mecom

DIOPT Version :10

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001376211.1 Gene:Mecom / 294924 RGDID:1310997 Length:1242 Species:Rattus norvegicus


Alignment Length:1214 Identity:363/1214 - (29%)
Similarity:506/1214 - (41%) Gaps:345/1214 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 PVEGSPPRRDHLDIQDQELLHHPNHFHQQNQRQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRA 127
            |:|..|...|...|.:...||          .|:|..|.  .|.||.:....|......:..|..
  Rat    25 PLEEMPDAEDADGIANAPSLH----------IQEPCSPA--TSSESFTPKEGSPYKAPIYIPDDI 77

  Fly   128 QAEHILQEWVRRREPV-CELDIRDSG------GVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWK 185
                          |: .|.::|:|.      |::.|..::.|.::||:..:......|....|:
  Rat    78 --------------PIPDEFELRESTMPGAGLGIWTKRKIEIGEKFGPYMGEQRSDLKDSSYGWE 128

  Fly   186 AHSRHYN-----GWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMV 245
            ......|     ...:|  ||.:|||.||..  .|..:.||.:......::|.....:..|.|::
  Rat   129 ILDEFCNVKFCIDASQP--DVGSWLKYIRFA--GCYDQHNLVACQINDQIFYRVVADIAPGEELL 189

  Fly   246 V----DGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPS--DDRSDR-- 302
            :    :..|..|:                                       ||.  ::|..|  
  Rat   190 LFMKSEEDPHEPM---------------------------------------APDIHEERQHRCE 215

  Fly   303 -------DNGSLYSGDEFSKDKKNS--SLIREGDIDFTDD-ENGFDIR-------CEVCDKVYPD 350
                   ....|....:|.....:|  |::.|   |...: |:..|:|       |:.||:|:||
  Rat   216 DCDQLFESKAELADHQKFPCSTPHSAFSMVEE---DLQQNLESESDLREIHGNQDCKECDRVFPD 277

  Fly   351 LDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSK-VFCDPSNLQ 414
            |..|:.|::.  |.::.|:.|.||...|..:..||:|: :||::.:.|.||||:| ||.||||||
  Rat   278 LQSLEKHMLS--HTEEREYKCDQCPKAFNWKSNLIRHQ-MSHDSGKHYECENCAKQVFTDPSNLQ 339

  Fly   415 RHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHAT 479
            ||||:.|||||.|.||||||||.||||||||:|||||||||.||||.|:|||||||||||||||.
  Rat   340 RHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHAD 404

  Fly   480 CRMQIKCDKCNQSFSTLTSLTKHKKFCDST---GPGPYRNQHVNRHHQHPHQHPLPHQPHLAATA 541
            ||.||||..|.|.|||.:||.||::||:..   ..|.:..|.::          ||         
  Rat   405 CRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGIS----------LP--------- 450

  Fly   542 TSTCPAPPRESSESSSSAAAAAVAAMSTPPNPF-LMFRTAPSF---FPGFPPYGF---PPFLP-- 597
              ..||..:.|..:...|....|....|..:|. |.|.|||.|   |||..|.|.   ||.:|  
  Rat   451 --GTPAMDKTSMVNMGHANPGLVDYFGTNRHPAGLTFPTAPGFSLSFPGLFPSGLYHRPPLIPAS 513

  Fly   598 ---------------QNPL--HPTNIP------MFFSKNPMDLGCGGPEITSPVSAFDQKLPFGF 639
                           |:||  ||..:|      ...||:|            ||.  |.| |...
  Rat   514 SPVKGLSSTEQSNKCQSPLLTHPQILPATQDILKALSKHP------------PVG--DNK-PVEL 563

  Fly   640 LKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQ 704
            |...:||.:..:|::::......::       |....|.:.|:.|..|::..||..:...|    
  Rat   564 LPERSSEERPLEKISDQSESSDLDD-------VSTPSGSDLETTSGSDLESDLESDKEKCK---- 617

  Fly   705 DDMKQEPERVS----------------------TPDQQQAEDDRKSIDIMSTPPPADTPSGGDGP 747
            ::.|...::||                      :.::|.|.....:..|.:....|:...|..|.
  Rat   618 ENGKMFKDKVSPLQNLASINNKKEYSNHSVFSASVEEQTAVSGAVNDSIKAIASIAEKYFGSTGL 682

  Fly   748 LDLSICRKRSAG-----SFFTAPAEDNLMLHRFMPRLHEFEAE--RGQPLKMRKSHSSAESSTSQ 805
            :.|   :.:..|     |.|..|     ....|...::.|...  |..||||...    ..|..:
  Rat   683 VGL---QDKKVGALPYPSMFPLP-----FFPAFSQSMYPFPDRDLRSLPLKMEPQ----SPSEVK 735

  Fly   806 KSHKGSSPTP----------TPTASPGLTPSPSPPTSAGG---ELSSTSEGGAVPTMAAAAFAAD 857
            |..||||.:|          .|..| |.:..|:.|.::..   :||..|...|..|..... ..:
  Rat   736 KLQKGSSESPFDLTTKRKDEKPLTS-GSSKLPATPATSQDQPLDLSMGSRSRASGTKLTEP-RKN 798

  Fly   858 H-------SALASGP----TLPQTHPTFHPLLLEEIYR---------------------SGFPFL 890
            |       |.:.:.|    :|....||  |..::.|||                     .||.|.
  Rat   799 HVFGEKKGSNMETRPSSDGSLQHARPT--PFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFH 861

  Fly   891 CQ---PGGRRGIEAL-----------------------LAGAASAAAPKRPLPPVKFSAGSVVGL 929
            .|   |..|..:.|:                       :....|..||...||......|     
  Rat   862 PQFPLPDQRTWMSAIENMAEKLESFSGLKPEASELLQSVPSMFSFRAPPNTLPENLLRKG----- 921

  Fly   930 KTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRC 994
              |:||:|::|||:||||||||||||||||||||.||||||:||||||||||||||||||:||:|
  Rat   922 --KERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKC 984

  Fly   995 ELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREE-----------YFDDIRKFMNRVY 1048
            .||||.||||||||||:||||:  .|...:.:||..:|.|.           ||.:||.|:    
  Rat   985 HLCDRCFGQQTNLDRHLKKHEN--GNMSGTATSSPHSELESAGAILDDKEDAYFTEIRNFI---- 1043

  Fly  1049 TPNSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNNNSSNISNNNS 1092
                  ||.....:.|.:.::.:|    ..:|.:..:..::.||
  Rat  1044 ------GNSNHGSQSPRNMEERMN----GSHFKDEKALATSQNS 1077

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978 27/137 (20%)
C2H2 Zn finger 341..363 CDD:275368 9/21 (43%)
C2H2 Zn finger 371..392 CDD:275368 7/20 (35%)
SFP1 <391..479 CDD:227516 70/88 (80%)
C2H2 Zn finger 400..421 CDD:275368 17/21 (81%)
SUF4-like 403..>445 CDD:411020 34/42 (81%)
C2H2 Zn finger 403..421 CDD:411020 14/18 (78%)
C2H2 Zn finger 429..449 CDD:275368 17/19 (89%)
C2H2 Zn finger 457..477 CDD:275368 17/19 (89%)
C2H2 Zn finger 486..504 CDD:275368 10/17 (59%)
PTZ00121 <641..>728 CDD:173412 16/108 (15%)
COG5048 935..>1028 CDD:227381 71/92 (77%)
zf-C2H2 935..957 CDD:395048 17/21 (81%)
C2H2 Zn finger 937..957 CDD:275368 16/19 (84%)
zf-H2C2_2 949..973 CDD:463886 21/23 (91%)
C2H2 Zn finger 965..986 CDD:275368 19/20 (95%)
C2H2 Zn finger 994..1014 CDD:275368 16/19 (84%)
MecomNP_001376211.1 SET 50..207 CDD:394802 36/215 (17%)
C2H2 Zn finger 214..263 CDD:275368 9/51 (18%)
C2H2 Zn finger 268..288 CDD:275368 9/21 (43%)
zf-H2C2_2 280..304 CDD:463886 7/25 (28%)
zf-C2H2 294..316 CDD:395048 7/22 (32%)
C2H2 Zn finger 296..316 CDD:275368 7/20 (35%)
C2H2 Zn finger 324..346 CDD:275368 17/21 (81%)
SFP1 <347..399 CDD:227516 44/51 (86%)
C2H2 Zn finger 354..374 CDD:275368 17/19 (89%)
zf-C2H2 380..402 CDD:395048 18/21 (86%)
C2H2 Zn finger 382..402 CDD:275368 17/19 (89%)
C2H2 Zn finger 411..429 CDD:275368 10/17 (59%)
DUF4045 <715..802 CDD:433066 23/92 (25%)
PHA00733 881..977 CDD:177301 53/102 (52%)
zf-C2H2 925..947 CDD:395048 17/21 (81%)
C2H2 Zn finger 927..947 CDD:275368 16/19 (84%)
zf-H2C2_2 939..963 CDD:463886 21/23 (91%)
C2H2 Zn finger 955..976 CDD:275368 19/20 (95%)
zf-C2H2 982..1004 CDD:395048 17/21 (81%)
C2H2 Zn finger 984..1004 CDD:275368 16/19 (84%)

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