DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF493

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001070146.1 Gene:ZNF493 / 284443 HGNCID:23708 Length:774 Species:Homo sapiens


Alignment Length:697 Identity:164/697 - (23%)
Similarity:265/697 - (38%) Gaps:160/697 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:...||:.  .||:.:.....|..:..|.||:|...||....|.:|:.| |.....|.||.|.
Human   155 QCDKYVKVFH--KLLNSNRHNTKHTGKKPFKCKKCGKSFCMLLHLCQHKRI-HIRENSYRCEECG 216

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|...|.|.|| |..|.|.:.:.. ||||:|...|.|..|:.||:..||:.||.|..::.|||.
Human   217 KAFIWFSTLTRH-RRVHTGEKSYKY-ECGKSFNQDSNLTTHKRIHTGQKPYKCEECGTSFYQFSY 279

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRH---HQHPHQHPL 531
            |.|||.:| |.....||::..::|:..::||.||..  ..|..||:.:...:.   ...|.:|.:
Human   280 LTRHKLIH-TREKPYKCEQYGKTFNQSSTLTGHKII--HNGEKPYKCEECGKAFSIFSTPTKHKI 341

  Fly   532 PHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFL 596
            .|....:......|.| .:|||..::.      ..:.|...|:.......:|..      |....
Human   342 IHTEEKSHRCEEYCKA-YKESSHLTTH------KRIHTGEKPYKCEECGKAFSI------FSTLT 393

  Fly   597 PQNPLHPTNIPMFFSKNPMDLGCG-----GPEITSPVSAFDQKLPFGFLKGE--NSESQAYDKVT 654
            ....:|..      .|:.....||     ...:|:.......:.|:   |.|  ......:..:|
Human   394 KHKIIHTE------EKSHRCEECGKAYKESSHLTTHKRIHTGEKPY---KCEECGKTFSVFSILT 449

  Fly   655 EKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ 719
            :.:::...|:..|.|...:||:      |||...|.::..|            :::|        
Human   450 KHKIIHTEEKPYKCEECGKAFK------RSSTLTKHRIIHT------------EEKP-------- 488

  Fly   720 QQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEA 784
            .:.|:..|:.:..||.........|:.|.....|.|....|       ..|.:|:.   :|..| 
Human   489 YKCEECGKAFNQSSTLSIHKIIHTGEKPYKCEECGKAFKRS-------STLTIHKM---IHTGE- 542

  Fly   785 ERGQPLKMRKS----HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGA 845
               :|.|..:.    :.|:..:|.::.|.|..|...              ...|...|..|    
Human   543 ---KPYKCEECGKAFNRSSHLTTHKRIHTGHKPYKC--------------KECGKSFSVFS---- 586

  Fly   846 VPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAA 910
                                ||     |.|.:    |:....|:.|:..|:              
Human   587 --------------------TL-----TKHKI----IHTDKKPYKCEECGK-------------- 608

  Fly   911 APKRPLPPVKFSAGSVVGLKTK-----DRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDR 970
                     .|:..|::.:..|     ..|.|:.|||.|.||::|..|.:.|:.::||.|:.|.:
Human   609 ---------AFNRSSILSIHKKIHTGEKPYKCEECGKAFKRSSHLAGHKQIHSVQKPYKCEECGK 664

  Fly   971 AFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ||||.|.|.:| :.||.:|:|::||.|.::|.:.:||:.|...|..|
Human   665 AFSIFSTLTKH-KIIHTEEKPYKCEKCGKTFYRFSNLNTHKIIHTGE 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 5/21 (24%)
C2H2 Zn finger 371..392 CDD:275368 8/20 (40%)
SFP1 <391..479 CDD:227516 37/87 (43%)
C2H2 Zn finger 400..421 CDD:275368 10/20 (50%)
SUF4-like 403..>445 CDD:411020 17/41 (41%)
C2H2 Zn finger 403..421 CDD:411020 8/17 (47%)
C2H2 Zn finger 429..449 CDD:275368 8/19 (42%)
C2H2 Zn finger 457..477 CDD:275368 10/19 (53%)
C2H2 Zn finger 486..504 CDD:275368 5/17 (29%)
PTZ00121 <641..>728 CDD:173412 15/88 (17%)
COG5048 935..>1028 CDD:227381 35/83 (42%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 8/23 (35%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
ZNF493NP_001070146.1 KRAB 13..73 CDD:214630
KRAB 13..52 CDD:279668
C2H2 Zn finger 184..204 CDD:275368 8/20 (40%)
C2H2 Zn finger 212..232 CDD:275368 10/20 (50%)
C2H2 Zn finger 241..259 CDD:275368 8/17 (47%)
COG5048 262..667 CDD:227381 106/539 (20%)
C2H2 Zn finger 267..287 CDD:275368 10/19 (53%)
C2H2 Zn finger 295..315 CDD:275368 6/21 (29%)
C2H2 Zn finger 351..371 CDD:275368 5/26 (19%)
zf-H2C2_2 363..387 CDD:290200 2/29 (7%)
C2H2 Zn finger 379..399 CDD:275368 2/25 (8%)
C2H2 Zn finger 407..427 CDD:275368 3/19 (16%)
zf-H2C2_2 419..443 CDD:290200 4/26 (15%)
C2H2 Zn finger 435..455 CDD:275368 2/19 (11%)
zf-H2C2_2 448..472 CDD:290200 6/29 (21%)
C2H2 Zn finger 463..483 CDD:275368 7/25 (28%)
C2H2 Zn finger 491..511 CDD:275368 4/19 (21%)
zf-H2C2_2 504..528 CDD:290200 4/23 (17%)
C2H2 Zn finger 519..539 CDD:275368 5/29 (17%)
zf-H2C2_2 532..556 CDD:290200 6/30 (20%)
C2H2 Zn finger 547..567 CDD:275368 2/19 (11%)
zf-H2C2_2 559..583 CDD:290200 5/37 (14%)
C2H2 Zn finger 575..595 CDD:275368 7/66 (11%)
C2H2 Zn finger 603..623 CDD:275368 5/42 (12%)
zf-H2C2_2 616..640 CDD:290200 7/23 (30%)
C2H2 Zn finger 631..651 CDD:275368 9/19 (47%)
C2H2 Zn finger 659..679 CDD:275368 9/20 (45%)
C2H2 Zn finger 687..707 CDD:275368 7/19 (37%)
C2H2 Zn finger 715..735 CDD:275368
C2H2 Zn finger 743..763 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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