DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF841

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001356754.1	Gene:	ZNF841 / 284371	HGNCID:	27611	Length:	925	Species:	Homo sapiens

Alignment Length:	784	Identity:	176/784 - (22%)
Similarity:	265/784 - (33%)	Gaps:	186/784 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 SAPSDDRSDRDNGSLYSGDEFSKD-KKNSSLIREGDIDFTD------------------------ 332
            |.|:.|.........|.|:|..|. :.:||||....|..|:
Human   247 SLPTQDEKTHIREKPYIGNECGKAFRVSSSLINHQMIHTTEKPYRCNESGKAFHRGSLLTVHQIV 311

  Fly   333 DENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRK 397
            ...|...:|:||.:::.....|.:|  ...|.....:.|.:|...|.....|..|:.| |...:.
Human   312 HTRGKPYQCDVCGRIFRQNSDLVNH--RRSHTGDKPYICNECGKSFSKSSHLAVHQRI-HTGEKP 373

  Fly   398 YSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSK 462
            |.|..|.|.|...|:|..| :..|.|.:.:.|.||||||..:|.|..|..||:..||:.|:||.|
Human   374 YKCNRCGKCFSQSSSLATH-QTVHTGDKPYKCNECGKTFKRNSSLTAHHIIHAGKKPYTCDVCGK 437

  Fly   463 AYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---HHQ 524
            .:.|.|.|.||:.:| |.....||::|.:.|...:.|..|::.  .||..||:.....:   .|.
Human   438 VFYQNSQLVRHQIIH-TGETPYKCNECGKVFFQRSRLAGHRRI--HTGEKPYKCNECGKVFSQHS 499

  Fly   525 HPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAV-AAMSTPPNPFLMFRTAPSF-FPGF 587
            |...|...|        |...|....|..::.:..:...| ..:.|...|:........| :.|:
Human   500 HLAVHQRVH--------TGEKPYKCNECGKAFNWGSLLTVHQRIHTGEKPYKCNVCGKVFNYGGY 556

  Fly   588 PPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDK 652
            ..........:.|||.....|.|:                                     .|..
Human   557 LSVHMRCHTGEKPLHCNKCGMVFT-------------------------------------YYSC 584

  Fly   653 VTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTP 717
            :...:.:...|:..|.....:.|          :| .|.|...|.....|:
Human   585 LARHQRMHTGEKPYKCNVCGKVF----------ID-SGNLSIHRRSHTGEK-------------- 624

  Fly   718 DQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFT--APAEDNLMLHRFMPRLH 780
             ..|..:..|.....|..........|:.|...:.|     |..:|  :....:|::|......|
Human   625 -PFQCNECGKVFSYYSCLARHRKIHTGEKPYKCNDC-----GKAYTQRSSLTKHLVIHTGENPYH 683

  Fly   781 --EFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLT--------PSPSPPTSAGG 835
              ||.....|..|:.:.|   .:.|.:|.||.|....|.:....|.        ..|......|.
Human   684 CNEFGEAFIQSSKLARYH---RNPTGEKPHKCSECGRTFSHKTSLVYHQRRHTGEMPYKCIECGK 745

  Fly   836 ELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEI-----YRSGF-------- 887
            ..:||:      |:|.      |..:.:|.         .|....|.     ||||.
Human   746 VFNSTT------TLAR------HRRIHTGE---------KPYKCNECGKVFRYRSGLARHWSIHT 789

  Fly   888 ---PFLCQPGGRR-GIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSA 948
               |:.|...|:. .:.::|.........::|                   |.|..|||.|...:
Human   790 GEKPYKCNECGKAFRVRSILLNHQMMHTGEKP-------------------YKCNECGKAFIERS 835

  Fly   949 NLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKK 1013
            ||..|.|.||||:||.|..|.:||...|.|.:|.| ||:.|:|::|..|.:|:..::.|.:|..|
Human   836 NLVYHQRNHTGEKPYKCMECGKAFGRRSCLTKHQR-IHSSEKPYKCNECGKSYISRSGLTKHQIK 899

  Fly  1014 HESE 1017
            |..|
Human   900 HAGE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	10/86 (12%)
		COG5048	935..>1028	CDD:227381	36/83 (43%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF841	NP_001356754.1	KRAB	8..69	CDD:214630
		COG5048	260..636	CDD:227381	97/453 (21%)
		C2H2 Zn finger	265..284	CDD:275368	6/18 (33%)
		C2H2 Zn finger	292..312	CDD:275368	0/19 (0%)
		C2H2 Zn finger	320..340	CDD:275368	5/21 (24%)
		C2H2 Zn finger	348..368	CDD:275368	6/20 (30%)
		C2H2 Zn finger	376..396	CDD:275368	7/20 (35%)
		C2H2 Zn finger	404..424	CDD:275368	10/19 (53%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		C2H2 Zn finger	460..480	CDD:275368	5/21 (24%)
		COG5048	484..886	CDD:227381	100/521 (19%)
		C2H2 Zn finger	488..508	CDD:275368	3/19 (16%)
		C2H2 Zn finger	516..536	CDD:275368	2/19 (11%)
		C2H2 Zn finger	544..564	CDD:275368	2/19 (11%)
		C2H2 Zn finger	572..592	CDD:275368	3/56 (5%)
		C2H2 Zn finger	600..620	CDD:275368	5/30 (17%)
		C2H2 Zn finger	628..648	CDD:275368	2/19 (11%)
		C2H2 Zn finger	656..676	CDD:275368	4/24 (17%)
		C2H2 Zn finger	712..732	CDD:275368	3/19 (16%)
		C2H2 Zn finger	740..760	CDD:275368	6/31 (19%)
		C2H2 Zn finger	768..788	CDD:275368	5/19 (26%)
		C2H2 Zn finger	796..816	CDD:275368	3/19 (16%)
		C2H2 Zn finger	824..844	CDD:275368	9/19 (47%)
		C2H2 Zn finger	852..872	CDD:275368	8/20 (40%)
		C2H2 Zn finger	880..900	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000