DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF345

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001229401.1 Gene:ZNF345 / 25850 HGNCID:16367 Length:488 Species:Homo sapiens


Alignment Length:734 Identity:155/734 - (21%)
Similarity:240/734 - (32%) Gaps:288/734 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   306 SLYSGDEFSK---DKKNSSLIREG---DIDFT-DDENGFDIRCEVCDKVYPDLDLLDDHLIGAHH 363
            |.:.||...|   ::|..|  :||   ::.|| :|...|.|:.:   :::.|..||:        
Human    12 SSFRGDWECKNQFERKQGS--QEGHFSEMIFTPEDMPTFSIQHQ---RIHTDEKLLE-------- 63

  Fly   364 FKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHP 428
                   ||:|...|....:|::|:.| |...:.|.|:.|.|.|...:||..|.| .|.|.:...
Human    64 -------CKECGKDFSFVSVLVRHQRI-HTGEKPYECKECGKAFGSGANLAYHQR-IHTGEKPFE 119

  Fly   429 CPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSF 493
            |.||||.||:.|.|..||.||:..||:.|:.|.||::..|.|.||:.:|:. ....:|.:|.:||
Human   120 CKECGKAFGSGSNLTHHQRIHTGEKPYECKECGKAFSFGSGLIRHQIIHSG-EKPYECKECGKSF 183

  Fly   494 STLTSLTKHKKFCDSTGPGPYRNQHVNR---------HHQHPHQHPLPHQPHLAATATSTCPAPP 549
            |..::|.:|.:.  .||..||......:         .|:..|....|::......|        
Human   184 SFESALIRHHRI--HTGEKPYECIDCGKAFGSGSNLTQHRRIHTGEKPYECKACGMA-------- 238

  Fly   550 RESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNP 614
                 .||.:|......:.|...|::...                                    
Human   239 -----FSSGSALTRHQRIHTGEKPYICNE------------------------------------ 262

  Fly   615 MDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEE 679
                ||        .||.    ||            ..:|..:.:...|:....:...:||....
Human   263 ----CG--------KAFS----FG------------SALTRHQRIHTGEKPYVCKECGKAFNSGS 299

  Fly   680 DESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGG 744
            |.:                           :.:|:.|                           |
Human   300 DLT---------------------------QHQRIHT---------------------------G 310

  Fly   745 DGPLDLSICRKR-SAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSH 808
            :.|.:...|.|. .:||        .|:.|                               |:.|
Human   311 EKPYECKECEKAFRSGS--------KLIQH-------------------------------QRMH 336

  Fly   809 KGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPT 873
            .|..|                        ....|.|              ...:||..|.|.|  
Human   337 TGEKP------------------------YECKECG--------------KTFSSGSDLTQHH-- 361

  Fly   874 FHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVV----GLKTKDR 934
                   .|:....|:.|:..|:                       .|.:||.:    .:.|.:|
Human   362 -------RIHTGEKPYECKECGK-----------------------AFGSGSKLIQHQLIHTGER 396

  Fly   935 -YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCD 998
             |.||.|||.|...:.|.||.|.||||:||.||.|.:||...|:|.:|.| ||..|:.:.|:.|.
Human   397 PYECKECGKSFSSGSALNRHQRIHTGEKPYECKECGKAFYSGSSLTQHQR-IHTGEKLYECKNCG 460

  Fly   999 RSFGQQTNLDRHVKKHESE 1017
            :::|:.:...:|.|.|..:
Human   461 KAYGRDSEFQQHKKSHNGK 479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 3/21 (14%)
C2H2 Zn finger 371..392 CDD:275368 7/20 (35%)
SFP1 <391..479 CDD:227516 36/87 (41%)
C2H2 Zn finger 400..421 CDD:275368 8/20 (40%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 7/17 (41%)
C2H2 Zn finger 429..449 CDD:275368 11/19 (58%)
C2H2 Zn finger 457..477 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..504 CDD:275368 7/17 (41%)
PTZ00121 <641..>728 CDD:173412 7/86 (8%)
COG5048 935..>1028 CDD:227381 35/83 (42%)
zf-C2H2 935..957 CDD:395048 11/21 (52%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 14/23 (61%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 5/19 (26%)
ZNF345NP_001229401.1 C2H2 Zn finger 64..84 CDD:275368 7/20 (35%)
COG5048 88..476 CDD:227381 130/632 (21%)
C2H2 Zn finger 92..112 CDD:275368 8/20 (40%)
C2H2 Zn finger 120..140 CDD:275368 11/19 (58%)
C2H2 Zn finger 148..168 CDD:275368 8/19 (42%)
C2H2 Zn finger 176..196 CDD:275368 7/21 (33%)
C2H2 Zn finger 204..224 CDD:275368 1/19 (5%)
C2H2 Zn finger 232..252 CDD:275368 4/32 (13%)
C2H2 Zn finger 260..280 CDD:275368 7/83 (8%)
C2H2 Zn finger 288..308 CDD:275368 4/46 (9%)
C2H2 Zn finger 316..336 CDD:275368 7/58 (12%)
C2H2 Zn finger 344..364 CDD:275368 7/42 (17%)
C2H2 Zn finger 372..392 CDD:275368 5/42 (12%)
C2H2 Zn finger 400..420 CDD:275368 10/19 (53%)
C2H2 Zn finger 428..448 CDD:275368 9/20 (45%)
C2H2 Zn finger 456..476 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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