DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF549

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001186224.2	Gene:	ZNF549 / 256051	HGNCID:	26632	Length:	640	Species:	Homo sapiens

Alignment Length:	677	Identity:	112/677 - (16%)
Similarity:	163/677 - (24%)	Gaps:	372/677 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 CEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSK 405
            |.||.|.:........|....|..:: .:.|.:|...|.|....|:|:.: |.....|.|..|.|
Human   334 CNVCGKSFRHKQTFVGHQQRIHTGER-PYVCMECGKSFIHSYDRIRHQRV-HTGEGAYQCSECGK 396

  Fly   406 VFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNL 470
            .|....:|..|.| .|.|.|.:.|.||||.|.....|.:||.||:..||:.|.:|.|::.:.|:.
Human   397 SFIYKQSLLDHHR-IHTGERPYECKECGKAFIHKKRLLEHQRIHTGEKPYVCIICGKSFIRSSDY 460

  Fly   471 CRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQP 535
            .||:|:| |.....:|..|.::|.:..:|.||                   |..|..:.|.
Human   461 MRHQRIH-TGERAYECSDCGKAFISKQTLLKH-------------------HKIHTRERPY---- 501

  Fly   536 HLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNP 600
                           |.||
Human   502 ---------------ECSE---------------------------------------------- 505

  Fly   601 LHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEK 665
                              ||                    ||                 |..|.|
Human   506 ------------------CG--------------------KG-----------------FYLEVK 515

  Fly   666 LKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSID 730
            |.:.                                          :|:.|.:|
Human   516 LLQH------------------------------------------QRIHTREQ----------- 527

  Fly   731 IMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKS 795
                                 :|.....|..|:  .:..|:.|
Human   528 ---------------------LCECNECGKVFS--HQKRLLEH---------------------- 547

  Fly   796 HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSA 860
                     ||.|.|..|
Human   548 ---------QKVHTGEKP----------------------------------------------- 556

  Fly   861 LASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGS 925
                                          |:
Human   557 ------------------------------CE--------------------------------- 558

  Fly   926 VVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKER 990
                       |..|||.|....:|.:|.:.|:||:||.|..|::||...:.|..|.| ||..|:
Human   559 -----------CSECGKCFRHRTSLIQHQKVHSGERPYNCTACEKAFIYKNKLVEHQR-IHTGEK 611

  Fly   991 PFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |:.|..|.::|.::.:|.||.|.|.:|
Human   612 PYECGKCGKAFNKRYSLVRHQKVHITE 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	33/87 (38%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	9/86 (10%)
		COG5048	935..>1028	CDD:227381	32/83 (39%)
		zf-C2H2	935..957	CDD:395048	7/21 (33%)
		C2H2 Zn finger	937..957	CDD:275368	7/19 (37%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF549	NP_001186224.2	KRAB	27..67	CDD:307490
		COG5048	223..603	CDD:227381	97/639 (15%)
		C2H2 Zn finger	224..241	CDD:275368
		C2H2 Zn finger	249..269	CDD:275368
		C2H2 Zn finger	277..298	CDD:275368
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..355	CDD:275368	5/20 (25%)
		C2H2 Zn finger	363..383	CDD:275368	6/20 (30%)
		C2H2 Zn finger	391..411	CDD:275368	7/20 (35%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/38 (18%)
		C2H2 Zn finger	503..523	CDD:275368	11/162 (7%)
		C2H2 Zn finger	531..551	CDD:275368	6/52 (12%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/20 (35%)
		zf-H2C2_2	600..624	CDD:316026	10/24 (42%)
		C2H2 Zn finger	615..635	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910