DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF718

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001034216.2	Gene:	ZNF718 / 255403	HGNCID:	26889	Length:	478	Species:	Homo sapiens

Alignment Length:	694	Identity:	135/694 - (19%)
Similarity:	202/694 - (29%)	Gaps:	330/694 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCEN------------------------- 402
            ||.|:.:..:.....| |:.:...||...|.|:|| :|::
Human    80 HFTQNLWTVQGIEDSF-HKLIPKGHEKRGHENLRK-TCKSINECKVQKGGYNRINQCLLTTQKKT 142

  Fly   403 -----CSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSK 462
                 |.|||...||..:. :..:.|.:...|.||||:|...|.|.||:.||:...|:.||.|.|
Human   143 IQSNICVKVFHKFSNSNKD-KIRYTGDKTFKCKECGKSFHVLSRLTQHKRIHTGENPYTCEECGK 206

  Fly   463 AYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPH 527
            |:...|.|.:|||:||..:. .||::|.:.|:..:.|||||:.  .||..||
Human   207 AFNWSSILTKHKRIHAREKF-YKCEECGKGFTRSSHLTKHKRI--HTGEKPY------------- 255

  Fly   528 QHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGF 592
                            .|..
Human   256 ----------------ICEK--------------------------------------------- 259

  Fly   593 PPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKE 657
                                      ||        .||:|.......|..:| :|.|.|..|..
Human   260 --------------------------CG--------KAFNQSSTLNLHKRIHS-AQKYYKCEECG 289

  Fly   658 LVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQA 722
            ..||....|.:...:.|
Human   290 KAFKWSSSLNEHKRIHA------------------------------------------------ 306

  Fly   723 EDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERG 787
                                 |:.|.....|     |:.||..::  ...|:   |:|..|
Human   307 ---------------------GEKPFSCEEC-----GNVFTTSSD--FAKHK---RIHTGE---- 336

  Fly   788 QPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAA 852
            :|.|..:...|...||:..:||
Human   337 KPYKCEECGKSFNRSTTLTTHK------------------------------------------- 358

  Fly   853 AFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLP 917
                                        .|:....|:.|:..|:
Human   359 ----------------------------RIHTGEKPYTCEECGK--------------------- 374

  Fly   918 PVKFSAGSVVGL-----KTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSN 977
              .|:..|.:.:     ..|:.|.|:.|||.|...|||..|.:.||||:||.||.|.:||..||:
Human   375 --AFNWSSTLNVHKRIHSGKNPYKCEDCGKAFKVFANLHNHKKIHTGEKPYICKQCGKAFKQSSH 437

  Fly   978 LQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNF 1021
            |.:| :.||..::|::|:.|.::|.|.:||.:|.:.|  .|..|
Human   438 LNKH-KKIHTVDKPYKCKECGKAFKQYSNLPQHKRTH--TGGKF 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	135/694 (19%)
		C2H2 Zn finger	371..392	CDD:275368	4/20 (20%)
		SFP1	<391..479	CDD:227516	36/117 (31%)
		C2H2 Zn finger	400..421	CDD:275368	7/50 (14%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	10/86 (12%)
		COG5048	935..>1028	CDD:227381	38/87 (44%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF718	NP_001034216.2	KRAB	4..64	CDD:214630
		C2H2 Zn finger	146..165	CDD:275368	6/19 (32%)
		C2H2 Zn finger	173..193	CDD:275368	10/19 (53%)
		C2H2 Zn finger	201..221	CDD:275368	10/19 (53%)
		COG5048	<225..386	CDD:227381	52/449 (12%)
		C2H2 Zn finger	229..249	CDD:275368	8/21 (38%)
		C2H2 Zn finger	257..277	CDD:275368	7/98 (7%)
		C2H2 Zn finger	285..305	CDD:275368	4/19 (21%)
		C2H2 Zn finger	313..333	CDD:275368	6/29 (21%)
		COG5048	<322..474	CDD:227381	54/257 (21%)
		C2H2 Zn finger	341..361	CDD:275368	5/90 (6%)
		C2H2 Zn finger	369..389	CDD:275368	4/42 (10%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		C2H2 Zn finger	425..445	CDD:275368	9/20 (45%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000