DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZKSCAN5

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001305011.1	Gene:	ZKSCAN5 / 23660	HGNCID:	12867	Length:	839	Species:	Homo sapiens

Alignment Length:	1144	Identity:	221/1144 - (19%)
Similarity:	332/1144 - (29%)	Gaps:	473/1144 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DFDPSASVARHHHHLHHLDLSARS----QGFNPLSEQIEDSFAARHHLPQQEPVEGSPPR----- 70
            |.||.|..::....|..:.:....    |.:||  ...|..:....|....   |.|.||
Human    11 DLDPPAETSQEQEDLFIVKVEEEDCTWMQEYNP--PTFETFYQRFRHFQYH---EASGPREALSQ 70

  Fly    71 ---------RDHLDIQDQ--ELL-------------------HHPNHFHQQNQRQQPPPPTLPLS 105
                     |..|..::|  |||                   |||
Human    71 LRVLCCEWLRPELHTKEQILELLVLEQFLTILPEEFQPWVREHHP-------------------- 115

  Fly   106 VESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFP 170
             ||...|.|.::.:....::|.|......:.:.|:               ..||........|.|
Human   116 -ESGEEAVAVIENIQRELEERRQQIVACPDVLPRK---------------MATPGAVQESCSPHP 164

  Fly   171 MKLSHQPND-PQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYET 234
            :.:..||.. ||                         |.|.:::
Human   165 LTVDTQPEQAPQ-------------------------KPRLLEE--------------------- 183

  Fly   235 NRYVNAGSEMVVDGRP-KSPVQLNEDFMNGG--KVLAAAAAAAAAVVAASSSGAKSGGGGSSAPS 296
                ||...:.|...| |...:|....::.|  |::.....|..||...............|...
Human   184 ----NALPVLQVPSLPLKDSQELTASLLSTGSQKLVKIEEVADVAVSFILEEWGHLDQSQKSLYR 244

  Fly   297 DDRSD------------RDNGSLYSGDEFSKDKKNSSLIRE-------GDIDFTD--DENGFDIR 340
            |||.:            |||..|.. .:.|.|.::..:..|       .|.||.:  |..|...|
Human   245 DDRKENYGSITSMGYESRDNMELIV-KQISDDSESHWVAPEHTERSVPQDPDFAEVSDLKGMVQR 308

  Fly   341 CEVCDKV---------YPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIR 396
            .:|...|         ..|||.:.|                            |..:..:|.. |
Human   309 WQVNPTVGKSRQNPSQKRDLDAITD----------------------------ISPKQSTHGE-R 344

  Fly   397 KYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCS 461
            .:.|.:|.|.|...||..:| |..|.|.:...|.||||::.....|.|||.:|:..||:.|:||.
Human   345 GHRCSDCGKFFLQASNFIQH-RRIHTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCG 408

  Fly   462 KAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHP 526
            ||:...|:|.:|..:|:..| ...|::|.::|...:.|.:|.|                ||.
Human   409 KAFRVSSHLVQHHSVHSGER-PYGCNECGKNFGRHSHLIEHLK----------------RHF--- 453

  Fly   527 HQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYG 591
                                   ||.|:..|...
Human   454 -----------------------REKSQRCSDKR------------------------------- 464

  Fly   592 FPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEK 656
                               |||                   .||.......|.||:       :.
Human   465 -------------------SKN-------------------TKLSVKKKISEYSEA-------DM 484

  Fly   657 ELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQ 721
            ||..|.:..:.:   ||.| ||..|.:..||.|..:             .||   |.:..|..
Human   485 ELSGKTQRNVSQ---VQDF-GEGCEFQGKLDRKQGI-------------PMK---EILGQPSS-- 527

  Fly   722 AEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAER 786
                 |.::....|......|.|:.|...:.|.|    ||..:.   :|:.|:   |:|..|
Human   528 -----KRMNYSEVPYVHKKSSTGERPHKCNECGK----SFIQSA---HLIQHQ---RIHTGE--- 574

  Fly   787 GQPLKMR---KSHSSAESSTS-QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVP 847
             :|.:..   ||::.....|. |:.|.|..|...|
Human   575 -KPFRCEECGKSYNQRVHLTQHQRVHTGEKPYTCP------------------------------ 608

  Fly   848 TMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR-GIEALLAG-----A 906
             :...||..            ::|...|    :.::....||.|...|:. |..:.|||     :
Human   609 -LCGKAFRV------------RSHLVQH----QSVHSGERPFKCNECGKGFGRRSHLAGHLRLHS 656

  Fly   907 ASAAAPKRPLPPVKFSAGSVV-------GLKTKDR-------------------------YSCKF 939
            ...:...|....:.|...|::       |.|.:..                         |.|..
Human   657 REKSHQCRECGEIFFQYVSLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCDI 721

  Fly   940 CGKVFPRSANLTRHLRTHTGEQPYPCKY----------------------------CDRAFSISS 976
            |||.|..|::|.:|.||||.|:||.|..                            |.|.|::.|
Human   722 CGKAFGYSSDLIQHYRTHTAEKPYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGRGFTLKS 786

  Fly   977 NLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHE 1015
            :|.:|.| ||..|:||:|:.|..:|....:|.:|::.||
Human   787 HLNQHQR-IHTGEKPFQCKECGMNFSWSCSLFKHLRSHE 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	16/123 (13%)
		C2H2 Zn finger	341..363	CDD:275368	6/30 (20%)
		C2H2 Zn finger	371..392	CDD:275368	1/20 (5%)
		SFP1	<391..479	CDD:227516	33/87 (38%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	19/86 (22%)
		COG5048	935..>1028	CDD:227381	36/109 (33%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	12/51 (24%)
		C2H2 Zn finger	965..986	CDD:275368	8/48 (17%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZKSCAN5	NP_001305011.1	SCAN	46..155	CDD:128708	24/147 (16%)
		SCAN	47..134	CDD:280241	19/110 (17%)
		KRAB	222..257	CDD:279668	6/34 (18%)
		COG5048	318..762	CDD:227381	132/680 (19%)
		C2H2 Zn finger	348..368	CDD:275368	8/20 (40%)
		zf-H2C2_2	360..385	CDD:290200	10/25 (40%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	388..411	CDD:290200	11/22 (50%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368	6/35 (17%)
		zf-C2H2	549..571	CDD:278523	7/31 (23%)
		C2H2 Zn finger	551..571	CDD:275368	7/29 (24%)
		zf-H2C2_2	563..588	CDD:290200	8/31 (26%)
		C2H2 Zn finger	579..599	CDD:275368	4/19 (21%)
		zf-H2C2_2	591..614	CDD:290200	6/53 (11%)
		C2H2 Zn finger	607..627	CDD:275368	5/66 (8%)
		zf-H2C2_2	619..644	CDD:290200	6/28 (21%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		C2H2 Zn finger	663..683	CDD:275368	3/19 (16%)
		zf-C2H2	717..739	CDD:278523	10/21 (48%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		C2H2 Zn finger	747..795	CDD:275368	8/48 (17%)
		COG5048	758..>823	CDD:227381	17/65 (26%)
		zf-C2H2	773..795	CDD:278523	7/22 (32%)
		zf-H2C2_2	787..811	CDD:290200	10/24 (42%)
		C2H2 Zn finger	803..823	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910