DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp51

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001295252.1	Gene:	Zfp51 / 22709	MGIID:	99198	Length:	781	Species:	Mus musculus

Alignment Length:	725	Identity:	149/725 - (20%)
Similarity:	251/725 - (34%)	Gaps:	232/725 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:.|:|.:..|..|..|  ...|..:..:.||:|...|.|.|....|:.| |.:....||..|.
Mouse   271 KCKECEKSFVQLSALKSH--QKLHTGEKPYKCKECDKSFAHYPNFRTHQKI-HTSEEHCSCPECG 332

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            :.|...|:|::|.| .|.|.:.:.|.||.::|...:.|:.||..|:....:.|:.|.|::.:.|:
Mouse   333 REFHQLSHLRKHYR-LHTGEKPYKCNECDRSFTHYASLRWHQKTHTPEIHYECKECGKSFIELSH 396

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---HHQHPHQHPL 531
            |.||.|:| |.....||:.|::||:|.|:|..|:|.  .||..||:.:..::   |..|..:|..
Mouse   397 LKRHYRIH-TGEKPYKCEICDKSFTTTTTLKTHQKI--HTGEKPYKCRECDKSFIHSSHLRRHQN 458

  Fly   532 PHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFL 596
            .|                                   |...|:.......||.
Mouse   459 VH-----------------------------------TGERPYRCKECDKSFH------------ 476

  Fly   597 PQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFK 661
                                                          |::..:.::|....|..:|
Mouse   477 ----------------------------------------------ESATLREHEKSHTGEKTYK 495

  Fly   662 AEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ-QQAEDD 725
            ..|                                .|....::..::....||.|.:: .:.::.
Mouse   496 CRE--------------------------------CDKSFTQRAYLRNHHNRVHTGERPYECKEC 528

  Fly   726 RKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPL 790
            .||....||.....|...|..|.....|     |..||    :|..| |...::|..|    :|.
Mouse   529 GKSFTTCSTLRIHQTIHTGKKPYKCIEC-----GKSFT----NNSYL-RTHQKVHSGE----KPY 579

  Fly   791 KMRKSHSSAESSTSQKSHK----GSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAA 851
            :.::...|..|.::.|:|:    |..|
Mouse   580 RCKECDKSFTSCSTLKAHQNIHTGEKP-------------------------------------- 606

  Fly   852 AAFAADHSALASGPTLPQ-THPTFHPLLLEEIYRSGFPFLCQPGGRRGIEAL-LAGAASAAAPKR 914
                  :..:....:..| :|...|    :.::....||.|....:..|.:. |.......:.::
Mouse   607 ------YKCIECDKSFTQVSHLRTH----QRVHTGERPFRCTECDKSFIRSSHLREHQKIHSGEK 661

  Fly   915 PLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQ 979
            |                   |.|:.|...|.:.:||.||.:.||||:||.|..||::|:.:||.:
Mouse   662 P-------------------YKCRDCDISFSQISNLRRHQKLHTGEKPYKCMECDKSFTHNSNFR 707

  Fly   980 RHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFR----DSPSS--SGIAEREEYFD 1038
            .|.| :|..|:|:||..||:||.:.:.|..|.|.|..| ..::    |.|::  |.:...:....
Mouse   708 THQR-VHTGEKPYRCAECDKSFTRCSYLRAHQKIHTGE-KPYKCMEYDKPNTQDSNLKRHQRVHT 770

  Fly  1039 DIR-KFMNRV 1047
            .:: .|:|.|
Mouse   771 GVKHTFLNNV 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	28/87 (32%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	13/41 (32%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	9/87 (10%)
		COG5048	935..>1028	CDD:227381	38/98 (39%)
		zf-C2H2	935..957	CDD:395048	8/21 (38%)
		C2H2 Zn finger	937..957	CDD:275368	7/19 (37%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
Zfp51	NP_001295252.1	KRAB	42..82	CDD:366587
		C2H2 Zn finger	216..236	CDD:275368
		SFP1	<239..318	CDD:227516	14/48 (29%)
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368	6/21 (29%)
		C2H2 Zn finger	300..320	CDD:275368	8/20 (40%)
		COG5048	327..749	CDD:227381	127/633 (20%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	9/21 (43%)
		C2H2 Zn finger	440..460	CDD:275368	3/19 (16%)
		C2H2 Zn finger	468..488	CDD:275368	4/77 (5%)
		C2H2 Zn finger	496..517	CDD:275368	3/52 (6%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	553..573	CDD:275368	7/29 (24%)
		C2H2 Zn finger	581..601	CDD:275368	4/19 (21%)
		C2H2 Zn finger	609..629	CDD:275368	3/23 (13%)
		C2H2 Zn finger	637..657	CDD:275368	3/19 (16%)
		C2H2 Zn finger	665..685	CDD:275368	7/19 (37%)
		C2H2 Zn finger	693..713	CDD:275368	8/20 (40%)
		C2H2 Zn finger	721..741	CDD:275368	8/19 (42%)
		C2H2 Zn finger	749..769	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000