DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp40

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001344626.1	Gene:	Zfp40 / 22700	MGIID:	99185	Length:	796	Species:	Mus musculus

Alignment Length:	752	Identity:	159/752 - (21%)
Similarity:	240/752 - (31%)	Gaps:	274/752 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|..|.|.|........:.|   |.:::.:.|..|...|.....|.:|..| |...|.|.|:.||
Mouse   282 KCIECGKCYYHSSFEKHYRI---HSEEESYKCNDCRKSFICCLGLKRHHKI-HGGERPYECKQCS 342

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|...|:|:.|.|.:.  .:.|.|.||||:..:||||::||.||...|.:.|..|:|.:.|.|.
Mouse   343 KSFYTSSHLENHYRTHR--RKLHRCNECGKSLSSSSGLQRHQRIHRGEKAYICAECNKCFIQKSQ 405

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYR----------NQHVNRHHQ 524
            |..|:|:| |.....||.:|.:||:..:||..|::.  .||..||:          ..|: |.||
Mouse   406 LKTHQRIH-TGEKSYKCSECEKSFTVGSSLRIHQRI--HTGEKPYKCSECHKCFIQQAHL-RRHQ 466

  Fly   525 HPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPP 589
            ..|....|::       .|.|        |.|.:..:.              .|.......|..|
Mouse   467 KIHTGEKPYK-------CSEC--------EKSFTVGSD--------------LRMHQKIHTGEKP 502

  Fly   590 YGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVT 654
            |                                                             |.:
Mouse   503 Y-------------------------------------------------------------KCS 506

  Fly   655 EKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ 719
            :.:..|..:.||||...:..  ||:....|..:   |.....:|.::.::....::|.:.|..|:
Mouse   507 DCDKCFIQKAKLKKHQRIHT--GEKPYKCSECE---KCFTVVSDLRTHQKIHTGEKPYKCSECDK 566

  Fly   720 QQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEA 784
                                             |..|.|          ||..|.   |:|
Mouse   567 ---------------------------------CFIRKA----------NLRRHH---RIH---- 581

  Fly   785 ERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTM 849
                              |.:|.:|.|.
Mouse   582 ------------------TGEKPYKCSD------------------------------------- 591

  Fly   850 AAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKR 914
            ....|....:.        :||        |.|:....|:.|:.|
Mouse   592 CGKCFIQKANL--------RTH--------ERIHTGEKPYKCECG-------------------- 620

  Fly   915 PLPPVKFSAGSVVGLKTK-----DRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSI 974
                ..|:.||.:....|     ..|.|..|.|.|.|.|:|.||.|.||||:||.|..|.:.|..
Mouse   621 ----KSFTVGSDLRKHQKCHTGEKPYKCSECNKCFIRKAHLRRHQRIHTGEKPYKCSDCGKCFIQ 681

  Fly   975 SSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREEYFDD 1039
            .:||:.| :.||..|:|::|..||:.|.|:.:|..|.:.|..|      .|......|:......
Mouse   682 KANLRTH-QKIHTGEKPYKCSECDKCFIQKDHLRTHQRLHTGE------KPYKCSECEKSFTGGS 739

  Fly  1040 IRKFMNRVYTPNSLAGNEGDTEEYPNSDDQSVNLEKD 1076
            :.:...:::|..||......|.  |.|...::.|.|:
Mouse   740 VLRKHQKIHTARSLTNAMNLTN--PLSKKPTLELIKE 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	14/86 (16%)
		COG5048	935..>1028	CDD:227381	37/92 (40%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	6/20 (30%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
Zfp40	NP_001344626.1	KRAB	42..82	CDD:307490
		C2H2 Zn finger	227..247	CDD:275368
		C2H2 Zn finger	255..275	CDD:275368
		COG5048	279..677	CDD:227381	132/644 (20%)
		C2H2 Zn finger	283..302	CDD:275368	5/21 (24%)
		C2H2 Zn finger	310..330	CDD:275368	6/20 (30%)
		C2H2 Zn finger	338..358	CDD:275368	9/19 (47%)
		C2H2 Zn finger	365..385	CDD:275368	11/19 (58%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368	7/21 (33%)
		C2H2 Zn finger	449..469	CDD:275368	4/20 (20%)
		C2H2 Zn finger	477..497	CDD:275368	5/41 (12%)
		C2H2 Zn finger	505..525	CDD:275368	5/19 (26%)
		C2H2 Zn finger	533..553	CDD:275368	3/22 (14%)
		C2H2 Zn finger	561..581	CDD:275368	9/65 (14%)
		C2H2 Zn finger	589..609	CDD:275368	5/72 (7%)
		C2H2 Zn finger	618..636	CDD:275368	5/41 (12%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	672..692	CDD:275368	6/20 (30%)
		zf-H2C2_2	684..709	CDD:316026	11/25 (44%)
		C2H2 Zn finger	700..720	CDD:275368	7/19 (37%)
		C2H2 Zn finger	728..748	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000