DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp35

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_035885.2	Gene:	Zfp35 / 22694	MGIID:	99179	Length:	580	Species:	Mus musculus

Alignment Length:	710	Identity:	155/710 - (21%)
Similarity:	243/710 - (34%)	Gaps:	241/710 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 GDIDFTDDENGF---DIRCEVCDKVYPDL-DLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIK 386
            |.|....:|:|.   |:..:...|.:.:. :.|:|.::    |::.::.|.:|...|.....||:
Mouse    35 GKIGTVTEESGSLEEDVPHDSRGKEFREFGEELNDQML----FRRRQYNCDECDQSFAWSTGLIR 95

  Fly   387 HEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSS 451
            |:   ..:.:.|.||.|.|.|...|.|..|.| .|.|.:.:||..|.|:|..||.|.:||.:|:.
Mouse    96 HQ---RTHWKPYECEECGKAFRMSSALVLHQR-IHTGEKPYPCSWCIKSFSRSSDLIKHQRVHTG 156

  Fly   452 VKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRN 516
            .||:.|:.|.||::|.|:|..|:|:| |.....:|..|::|||..:.:.||.:.  .||..||..
Mouse   157 EKPYKCDECGKAFSQSSDLMIHQRIH-TGEKPYQCSHCSKSFSQHSGMVKHLRI--HTGEKPYMC 218

  Fly   517 QHVNRH---------HQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPN 572
            .|..:|         ||..|....|::          |....:..|:||.......:   .|...
Mouse   219 NHCYKHFSQSSDLIKHQRIHTGEKPYK----------CDVCGKAFSQSSDRILHQRI---HTGEK 270

  Fly   573 PFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKL-- 635
            |:...:...||...      ...:....:|....|...|:      ||.....|.|....|::
Mouse   271 PYPCAQCNKSFSQN------SDLIKHRRIHTGEKPYKCSE------CGKAFNQSSVLILHQRIHT 323

  Fly   636 ---PFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRN 697
               |:...:...|.|:..|.:..:.:                ..||:....|..   .|:...|:
Mouse   324 GEKPYPCNQCTKSFSRLSDLINHQRI----------------HTGEKPYPCSQC---SKMFSRRS 369

  Fly   698 DSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFF 762
            |....         .|:.|                           |:.|.:...|.|
Mouse   370 DLVKH---------YRIHT---------------------------GEKPYECDKCGK------- 391

  Fly   763 TAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSP 827
            |.....||:||                               |:.|.|..|.|..:.|...
Mouse   392 TFSQSSNLILH-------------------------------QRIHTGEKPYPCNSCSKSF---- 421

  Fly   828 SPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQ 892
                |.|.:|                  ..|..:.:|
Mouse   422 ----SRGSDL------------------IKHQRVHTG---------------------------- 436

  Fly   893 PGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTH 957
                                ::|                   |:|..|.|.|.:|::||:|.|.|
Mouse   437 --------------------EKP-------------------YTCNLCSKSFSQSSDLTKHQRVH 462

  Fly   958 TGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            :||:||.|..|::||..||:|..|.| :|..|||:.|..|.|||.|:::|.:|.:.|..|
Mouse   463 SGEKPYHCSSCNKAFRQSSDLILHHR-VHTGERPYACTQCPRSFSQKSDLIKHQRIHTGE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	3/22 (14%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	38/83 (46%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
Zfp35	NP_035885.2	C2H2 Zn finger	80..100	CDD:275368	6/22 (27%)
		COG5048	102..489	CDD:227381	126/602 (21%)
		C2H2 Zn finger	106..126	CDD:275368	9/20 (45%)
		C2H2 Zn finger	134..154	CDD:275368	9/19 (47%)
		C2H2 Zn finger	162..182	CDD:275368	9/19 (47%)
		C2H2 Zn finger	190..210	CDD:275368	7/21 (33%)
		C2H2 Zn finger	218..238	CDD:275368	4/19 (21%)
		C2H2 Zn finger	246..266	CDD:275368	4/22 (18%)
		C2H2 Zn finger	274..294	CDD:275368	2/25 (8%)
		C2H2 Zn finger	302..322	CDD:275368	6/25 (24%)
		C2H2 Zn finger	330..350	CDD:275368	3/35 (9%)
		C2H2 Zn finger	358..378	CDD:275368	5/31 (16%)
		C2H2 Zn finger	386..406	CDD:275368	8/57 (14%)
		C2H2 Zn finger	414..434	CDD:275368	5/45 (11%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		C2H2 Zn finger	470..490	CDD:275368	9/20 (45%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
		C2H2 Zn finger	526..545	CDD:275368
		zf-H2C2_2	541..562	CDD:404364
		C2H2 Zn finger	553..573	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000