DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp26

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	1143	Identity:	240/1143 - (20%)
Similarity:	378/1143 - (33%)	Gaps:	387/1143 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PSASVARHHHHLHHLDLSARSQGFNPLSEQIEDSFAARHHLPQQEPVEG---------------- 66
            |.|.....|..|..::|..:.|..:...||   .|..||...:.:.|:.
Mouse    67 PGAVAVEEHTSLAAVELEKQLQTKDLAPEQ---DFLTRHTFMETQQVDAVTFEDVAVDFTQEEWT 128

  Fly    67 --SPPRRD-HLDIQDQELLHHPNHFHQQNQRQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRAQ 128
              .|.:|: :.|:..:      |:.:......|...|:|...:|..........|
Mouse   129 SLDPVQRNLYRDVMLE------NYQNLATVGGQMFKPSLISWLEKKVELTVIEQG---------- 177

  Fly   129 AEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNG 193
               |||||        |:.::..     :|.||:...:       |...|..||     .|.::|
Mouse   178 ---ILQEW--------EMHLKTK-----RTALQQDRFW-------SDMSNGMQL-----GREHSG 214

  Fly   194 WLEPTEDVSTWLKKIRSV--QDDCIGEANLQSYINAGYLWYETNRYVNAGSEMV--VDGRPKSP- 253
            . ||.:.|     ::.:|  :|.|     .|::.:..          |.|:...  :||:...|
Mouse   215 G-EPGDPV-----QVGAVFSEDSC-----PQTHSSTS----------NTGNTFACNLDGKDFQPL 258

  Fly   254 ----------VQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLY 308
                      ||||:             .....:.....|..|.....|...||
Mouse   259 LKETSTEENIVQLNQ-------------CVKPLIFTPDVSQKKCTPEKSVECSD----------- 299

  Fly   309 SGDEFSKD---KKNSSLIREGDIDFTDD----------ENGFDI-------RCEVCDKVYPDLDL 353
            .|:.|...   :.:||..||.:|..:::          ..|..|       .|:.|:|.:.....
Mouse   300 CGETFVNQLELQTHSSSHREKNIHKSEECGQASTHPISHGGHVIPTEKKYYECKKCEKFFTHPVY 364

  Fly   354 LDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIR 418
            |:.|:  ..|..:..:.||:|...|..|..||.| ...|...:.|.|:.|.|.|..||.|..|:|
Mouse   365 LNIHM--QSHTVEKPYDCKECGKAFTERSSLIVH-LRQHTREKSYECKECGKTFIQPSRLTEHMR 426

  Fly   419 AYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHA----- 478
            : |.|.:.:.|.:||..|.:||.|..|...|:..|||.|.:|.||:|:.|.|..|.|.|.
Mouse   427 S-HTGEKPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTGEKPY 490

  Fly   479 TCRMQIK----------------------CDKCNQSFSTLTSLTKHKKFCDSTGPGP-------- 513
            .|::..|                      |.:|.::|::...||:|.|  ..||..|
Mouse   491 ECKVCGKAFSGRSWLTIHLRKHTGERPYPCTECEKAFTSFAQLTEHIK--THTGEKPFRCKVCAR 553

  Fly   514 -YRNQHVNRHHQHPHQHPLPHQPHL---AATATSTCP--------APPRESSES----SSSAAAA 562
             :||....:.|...|....|::.:.   |.||.|...        ..|.|..|.    |:|:...
Mouse   554 TFRNSSCLKTHFRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSSGLV 618

  Fly   563 AVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSP 627
            ....:.|...||..::                                        ||      .
Mouse   619 EHIRIHTGEKPFECYQ----------------------------------------CG------K 637

  Fly   628 VSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDE---SRSSLDIK 689
            ..|....| .|.|:....|                          :.||..:.:   :|||. ::
Mouse   638 ALAHSSSL-VGHLRTHTGE--------------------------KPFECNQCDKTFTRSSY-LR 674

  Fly   690 GKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICR 754
            ..:.....:...|.::..|..|||.......:...                   |:.|.:...|
Mouse   675 IHMRTHTGEKPYECKECGKTFPERSCLTKHIRTHT-------------------GERPYECKEC- 719

  Fly   755 KRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKS----HKGSSPTP 815
                |..|.:.|:  |.:|   .:.|..|    :|.:.:....|..:|:|.::    |.|..|..
Mouse   720 ----GKGFISFAQ--LTVH---IKTHSSE----RPFQCKVCTKSFRNSSSLETHFRIHTGVKPYK 771

  Fly   816 TP------TASPGLTPSPSPPTSAGGELS-STSEGGAVPTMAAAAFAADHSALASGPTLPQTHPT 873
            ..      ||..|||......|   ||.| :..|.|       .||:.....:|        |..
Mouse   772 CSYCGKAFTARSGLTIHLRNHT---GEKSYACQECG-------KAFSTSSGLIA--------HIR 818

  Fly   874 FHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTK-----D 933
            .|        :...||.|...|:                       .|::.|.:.:..|     .
Mouse   819 SH--------KGEKPFECDHCGK-----------------------AFASSSYLNVHLKIHTGEK 852

  Fly   934 RYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCD 998
            .:.|..|||.|..|:.|..|:||||||:|:.|..|.::|..||.|:.|:| ||..|:|:.|:.|.
Mouse   853 PFQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSFLWSSYLRVHMR-IHTGEKPYVCQYCG 916

  Fly   999 RSFGQQTNLDRHVKKHESE--------GNNFRDSPSSS 1028
            ::|.:.:.|::|::||..|        |.||..|..::
Mouse   917 KAFTEHSGLNKHLRKHTGEKPYEYKECGENFTTSADAN 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	26/125 (21%)
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	35/92 (38%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	11/89 (12%)
		COG5048	935..>1028	CDD:227381	39/100 (39%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630	8/63 (13%)
		C2H2 Zn finger	297..317	CDD:275368	6/30 (20%)
		COG5048	325..760	CDD:227381	111/547 (20%)
		C2H2 Zn finger	352..372	CDD:275368	5/21 (24%)
		C2H2 Zn finger	380..400	CDD:275368	8/20 (40%)
		C2H2 Zn finger	408..428	CDD:275368	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		C2H2 Zn finger	492..512	CDD:275368	2/19 (11%)
		C2H2 Zn finger	520..540	CDD:275368	7/21 (33%)
		C2H2 Zn finger	548..568	CDD:275368	3/19 (16%)
		C2H2 Zn finger	576..596	CDD:275368	4/19 (21%)
		COG5048	600..956	CDD:227381	104/512 (20%)
		C2H2 Zn finger	604..624	CDD:275368	3/19 (16%)
		C2H2 Zn finger	632..652	CDD:275368	6/66 (9%)
		C2H2 Zn finger	660..680	CDD:275368	3/20 (15%)
		C2H2 Zn finger	688..708	CDD:275368	4/19 (21%)
		C2H2 Zn finger	716..736	CDD:275368	6/29 (21%)
		C2H2 Zn finger	744..764	CDD:275368	3/19 (16%)
		C2H2 Zn finger	772..792	CDD:275368	5/19 (26%)
		C2H2 Zn finger	800..820	CDD:275368	6/34 (18%)
		C2H2 Zn finger	828..848	CDD:275368	5/42 (12%)
		C2H2 Zn finger	856..876	CDD:275368	9/19 (47%)
		C2H2 Zn finger	884..904	CDD:275368	8/20 (40%)
		C2H2 Zn finger	912..932	CDD:275368	5/19 (26%)
		C2H2 Zn finger	940..956	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000