DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp11

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_766050.1	Gene:	Zfp11 / 22648	MGIID:	99156	Length:	647	Species:	Mus musculus

Alignment Length:	710	Identity:	151/710 - (21%)
Similarity:	233/710 - (32%)	Gaps:	269/710 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :||.|.:.:..|.:|..|.|  .|..:..|.||:|...|.:...|.:||.| |...:.|.|:.|.
Mouse   114 KCEECGRAFSALSVLTQHRI--THTGEKPFKCKECGRAFKYNSTLTQHEVI-HTEAKPYRCQECG 175

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|.....|.:| :..|.|.:.|.|.|||:.|...|.|.|||.||:..||:.|..|.||:...|.
Mouse   176 KAFKRSHTLSQH-QVIHKGEKPHKCDECGRAFSKHSSLTQHQVIHTGEKPYQCRECGKAFRYQST 239

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---------HHQH 525
            |.||..:| |.....||.:|:::|:..::|::|:..  .||..||:.|...|         .|..
Mouse   240 LTRHHIVH-TGAKPYKCPECDKAFNNSSTLSRHQII--HTGEKPYKCQECGRAFYCSSFLIQHMK 301

  Fly   526 PHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSF------- 583
            .|...:|::       ...|..|.|.||:      ......:.|...|::......:|
Mouse   302 IHFEEMPYR-------CRECGKPFRLSSQ------LIRHQRIHTGEEPYICRECGKTFKYQSNLT 353

  Fly   584 -----FPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGE 643
                 ..|..||..|.                        ||        .||:
Mouse   354 RHQILHTGAKPYKCPE------------------------CG--------KAFN----------- 375

  Fly   644 NSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMK 708
            ||.:     :|..:::...|:..|
Mouse   376 NSST-----LTRHQIIHTGEKPYK----------------------------------------- 394

  Fly   709 QEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLH 773
                                                        |::.|...:.::....::.:|
Mouse   395 --------------------------------------------CQECSKAFYCSSYLIQHMKIH 415

  Fly   774 RFMPRLHEFE------AERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTS 832
                    ||      .|.|:|.|     .|::....|:.|.|..|...              ..
Mouse   416 --------FEEIPYRCKECGKPFK-----CSSQLIRHQRIHSGEKPYIC--------------KE 453

  Fly   833 AGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR 897
            .|...:.||            :...|..:.:|..                     |::||..|:
Mouse   454 CGKAFNCTS------------YLTKHQRIHTGEK---------------------PYVCQECGK- 484

  Fly   898 GIEALLAGAASAAAPKRPLPPVKFSAGSVVG----LKTKDR-YSCKFCGKVFPRSANLTRHLRTH 957
                                  .|:..|.:.    :...|| |.||.|||.:..|:.|.||.|.|
Mouse   485 ----------------------AFNCSSYLSKHQRIHIGDRLYKCKECGKAYYFSSQLNRHQRIH 527

  Fly   958 TGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |||:||.|:.|.:||:.||.|.:|.| ||..|:|:.|:.|.::|...:.|.:|.:.|..:
Mouse   528 TGEKPYVCQECGKAFNCSSYLTKHQR-IHIVEKPYVCKECSKAFSCSSYLTKHQRIHAGD 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/21 (33%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	6/20 (30%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	5/17 (29%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	36/83 (43%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
Zfp11	NP_766050.1	C2H2 Zn finger	59..79	CDD:275368
		COG5048	83..460	CDD:227381	103/525 (20%)
		C2H2 Zn finger	87..107	CDD:275368
		C2H2 Zn finger	115..135	CDD:275368	7/21 (33%)
		zf-H2C2_2	128..152	CDD:290200	9/25 (36%)
		C2H2 Zn finger	143..163	CDD:275368	8/20 (40%)
		C2H2 Zn finger	171..191	CDD:275368	6/20 (30%)
		C2H2 Zn finger	199..219	CDD:275368	10/19 (53%)
		C2H2 Zn finger	227..247	CDD:275368	8/19 (42%)
		C2H2 Zn finger	255..275	CDD:275368	5/21 (24%)
		C2H2 Zn finger	283..303	CDD:275368	3/19 (16%)
		DUF45	<308..349	CDD:302795	9/53 (17%)
		C2H2 Zn finger	311..331	CDD:275368	5/25 (20%)
		COG5048	335..>645	CDD:227381	78/469 (17%)
		C2H2 Zn finger	339..359	CDD:275368	1/19 (5%)
		C2H2 Zn finger	367..387	CDD:275368	8/67 (12%)
		C2H2 Zn finger	395..415	CDD:275368	2/19 (11%)
		C2H2 Zn finger	423..443	CDD:275368	6/24 (25%)
		C2H2 Zn finger	451..471	CDD:275368	4/45 (9%)
		zf-H2C2_2	463..488	CDD:290200	7/68 (10%)
		C2H2 Zn finger	479..499	CDD:275368	5/42 (12%)
		C2H2 Zn finger	507..527	CDD:275368	10/19 (53%)
		zf-H2C2_2	520..544	CDD:290200	14/23 (61%)
		C2H2 Zn finger	535..555	CDD:275368	9/20 (45%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		C2H2 Zn finger	591..611	CDD:275368
		zf-H2C2_2	604..628	CDD:290200
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000