DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and zag-1

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_500424.3	Gene:	zag-1 / 177144	WormBaseID:	WBGene00006970	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	136/679 - (20%)
Similarity:	224/679 - (32%)	Gaps:	212/679 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 CPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHK------------------- 474
            ||||.|.|.....||:|..|||..|||.|:.|.|.::...:...|.
Worm    26 CPECTKAFKFKHHLKEHIRIHSGEKPFECQQCHKRFSHSGSYSSHMSSKKCVQQASPSMVTPFNP 90

  Fly   475 ---RMHATCRMQIKCDKC---------NQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQ--- 524
               .|:....:|::..:.         |..:.:|......:...:.|.|.|.:........:
Worm    91 YQLMMYRNIMLQLQTPQVSFLPSTAANNMDYMSLLQANLFQSLENGTSPTPTQEPSAPASPEPKI 155

  Fly   525 ----HPH---------------QHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTP 570
                .|.               :..:|.:....|.:.|..|||.:..:||.::..:.:....|
Worm   156 EVVDEPEVSSEVKTEVKTEVKTEDSVPEESITPAVSMSLSPAPEQNGNESMNNGGSGSDGKSS-- 218

  Fly   571 PNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPM----DLGCGGPEI------- 624
                          |.:.|.....||  |......:...|.:||.    :|.....:|
Worm   219 --------------PDWRPLRSRSFL--NDSQVAVLQNHFKRNPFPSKYELSAVAEQIGVNKRVV 267

  Fly   625 ------TSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEP--LVQAFEGEEDE 681
                  |........:||          |.....|............:.:.|  |:.|:..:...
Worm   268 QVWFQNTRAKERRSNRLP----------SMPRGSVASAAAAAATSPTVWQTPVQLMAAWASQFSN 322

  Fly   682 SRSSLDIKGKLEDTRNDSKSEE---QDDMKQEPERVSTP-DQQQAEDDRKSIDIMSTPPPADTPS 742
            ..:||...   :|.||:..::|   .|.:|...|   || |...:.||.:         |..:|.
Worm   323 GNNSLTAS---QDERNNENTDEVMDHDGLKDGKE---TPLDLTLSTDDTE---------PEWSPE 372

  Fly   743 GGDGPLDLS--ICRK--RSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESST 803
            ...|.||.:  :.::  |.||:.|....||                |..:|:|..:|..|:.||:
Worm   373 KLIGFLDQTGGVIQELLRQAGNGFVTNQED----------------EEEKPIKAEESPVSSGSSS 421

  Fly   804 SQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLP 868
            ...|..|..|:...:||..:...     :...:.||..:        |::..::.|.|...||.|
Worm   422 IWPSFIGQYPSILDSASLSVLEK-----ALDQQKSSEDD--------ASSLCSNESKLLKFPTTP 473

  Fly   869 QTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKD 933
                     |.||                  |.|
Worm   474 ---------LKEE------------------EGL------------------------------- 480

  Fly   934 RYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCD 998
             :||..|.|||.:.::|.||...|:|::||.|..|::||....:|..|.| :|:.|:||:|:.|.
Worm   481 -FSCDQCDKVFGKQSSLARHKYEHSGQRPYKCDICEKAFKHKHHLTEHKR-LHSGEKPFQCDKCL 543

  Fly   999 RSFGQQTNLDRHVKKHESEGNNFRDSPSS 1027
            :.|....:..:|:....|....:|:.|:|
Worm   544 KRFSHSGSYSQHMNHRYSYCKPYREQPAS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368
		C2H2 Zn finger	371..392	CDD:275368
		SFP1	<391..479	CDD:227516	20/71 (28%)
		C2H2 Zn finger	400..421	CDD:275368
		SUF4-like	403..>445	CDD:411020	8/15 (53%)
		C2H2 Zn finger	403..421	CDD:411020
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	4/41 (10%)
		C2H2 Zn finger	486..504	CDD:275368	2/26 (8%)
		PTZ00121	<641..>728	CDD:173412	19/92 (21%)
		COG5048	935..>1028	CDD:227381	32/93 (34%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	4/19 (21%)
zag-1	NP_500424.3	zf-C2H2	24..46	CDD:278523	9/19 (47%)
		C2H2 Zn finger	26..46	CDD:275368	9/19 (47%)
		zf-H2C2_2	38..61	CDD:290200	12/22 (55%)
		homeodomain	225..282	CDD:238039	9/58 (16%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		zf-H2C2_2	495..520	CDD:290200	11/24 (46%)
		COG5048	506..>559	CDD:227381	17/53 (32%)
		C2H2 Zn finger	511..531	CDD:275368	7/20 (35%)
		zf-H2C2_2	523..548	CDD:290200	10/25 (40%)
		C2H2 Zn finger	539..556	CDD:275368	3/16 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910