DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Giot1

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_598247.1	Gene:	Giot1 / 171090	RGDID:	620184	Length:	654	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	149/776 - (19%)
Similarity:	208/776 - (26%)	Gaps:	385/776 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 DRSDRDNGSL----------YSGDEFSKDKKNSSLIRE-----GDIDFTDDENG--FDIR----- 340
            |::.|.:.||          |...::.||..:.|.::|     |:..:..::.|  |..|
  Rat   213 DKAFRSDSSLHQRPHLEVAPYKYYQYEKDFAHHSCLQEHRTHTGEKPYKCNQCGKAFASRHNLKM 277

  Fly   341 ------------CEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHN 393
                        |..|.|.:.....|..|  ...|..:..:.|.||...|..|..|..||.| |.
  Rat   278 HERIHTGEKPYTCNQCGKAFTLYTNLRKH--EKIHTGEKPYECSQCGKAFARRNELQVHERI-HT 339

  Fly   394 NIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACE 458
            ..:.|.|..|.|.|...||||.|.|. |.|.:.:.|.:|||.|.....|:.|:.||:..||:||.
  Rat   340 GEKPYECSQCGKAFASRSNLQTHERT-HTGEKPYLCNQCGKAFAWRRLLQIHERIHTGEKPYACN 403

  Fly   459 VCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHH 523
            .|.||:|.|.:|..||::| |......|::|.::|:.|||...|||.  .||..||
  Rat   404 QCGKAFTHFPSLHNHKKIH-TGEKPYTCNECGKAFAHLTSFHNHKKI--HTGEKPY--------- 456

  Fly   524 QHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFP 588

  Rat   457 ----------------------------------------------------------------- 456

  Fly   589 PYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKV 653
                                         ||                                |.
  Rat   457 -----------------------------GC--------------------------------KQ 460

  Fly   654 TEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPD 718
            ..|...|::..::.:    .|.:||            |..:.....|:.......|..||
  Rat   461 CGKAFSFRSNLQIHE----TAHKGE------------KPHECNQCGKAFAHIVYLQRHER----- 504

  Fly   719 QQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFE 783
                                   |.||.|.:.:.|     |..||           ...||
  Rat   505 -----------------------SHGDKPYECNQC-----GKGFT-----------HFGRL---- 526

  Fly   784 AERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPT 848
                      |:|        .|||.|..|
  Rat   527 ----------KNH--------LKSHTGEKP----------------------------------- 538

  Fly   849 MAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPK 913

  Rat   539 ----------------------------------------------------------------- 538

  Fly   914 RPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNL 978
                                 |.|..|||||....||.:|.||||||:||.|..|.:||:...||
  Rat   539 ---------------------YECNQCGKVFAYRNNLQKHERTHTGEKPYVCDQCGKAFASRCNL 582

  Fly   979 QRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNF-----RDSPSSSGIAERE 1034
            |:| ..||.:|:|:.|..|.::|..:.|...|.:.|..|.:..     :|..|.|.:.:.|
  Rat   583 QKH-EKIHTQEKPYVCNQCGKAFASRCNFQVHERIHTGEKSYSYNQCGKDFVSQSNLQKHE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	9/20 (45%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	9/17 (53%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	39/97 (40%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	14/23 (61%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
Giot1	NP_598247.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	131..151	CDD:275368
		C2H2 Zn finger	159..176	CDD:275368
		C2H2 Zn finger	182..201	CDD:275368
		COG5048	258..654	CDD:227381	139/731 (19%)
		C2H2 Zn finger	262..282	CDD:275368	3/19 (16%)
		zf-H2C2_2	274..298	CDD:290200	3/23 (13%)
		C2H2 Zn finger	290..310	CDD:275368	5/21 (24%)
		zf-H2C2_2	302..327	CDD:290200	7/26 (27%)
		C2H2 Zn finger	318..338	CDD:275368	9/20 (45%)
		zf-H2C2_2	330..355	CDD:290200	10/25 (40%)
		C2H2 Zn finger	346..366	CDD:275368	10/20 (50%)
		zf-H2C2_2	358..382	CDD:290200	11/24 (46%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		zf-H2C2_2	387..411	CDD:290200	11/23 (48%)
		C2H2 Zn finger	402..422	CDD:275368	9/19 (47%)
		zf-H2C2_2	417..439	CDD:290200	7/22 (32%)
		C2H2 Zn finger	430..450	CDD:275368	9/21 (43%)
		C2H2 Zn finger	458..478	CDD:275368	4/55 (7%)
		C2H2 Zn finger	486..506	CDD:275368	4/47 (9%)
		zf-C2HE	<508..533	CDD:292895	11/62 (18%)
		C2H2 Zn finger	513..533	CDD:275368	9/57 (16%)
		zf-H2C2_2	526..550	CDD:290200	15/166 (9%)
		C2H2 Zn finger	541..561	CDD:275368	10/19 (53%)
		zf-H2C2_2	553..578	CDD:290200	15/24 (63%)
		C2H2 Zn finger	569..589	CDD:275368	8/20 (40%)
		zf-H2C2_2	581..606	CDD:290200	11/25 (44%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000