DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF721

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	840	Identity:	192/840 - (22%)
Similarity:	299/840 - (35%)	Gaps:	247/840 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 DRDNG-----------SLYSGDEFSKDKK------NSSLIREGDIDFTDDENGFDIRCEVCDKVY 348
            |||..           .:::||:..|.|:      :||.:.:.:...|.::   ..:|:.|.||.
Human   197 DRDRAFGWSTNLNEYKKIHTGDKPYKCKECGKAFMHSSHLNKHEKIHTGEK---PYKCKECGKVI 258

  Fly   349 PDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNL 413
            ........|  ...|..:..|.|.:|...|.....|.||..| |...:.|:||.|.|.|...:||
Human   259 SSSSSFAKH--KRIHTGEKPFKCLECGKAFNISTTLTKHRRI-HTGEKPYTCEVCGKAFRQSANL 320

  Fly   414 QRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHA 478
            ..| |..|.|.:.:.|.||||||..|:.|..|:.||:..||:.||.|.||:.:::.|.:||::|
Human   321 YVH-RRIHTGEKPYTCGECGKTFRQSANLYVHRRIHTGEKPYKCEDCGKAFGRYTALNQHKKIH- 383

  Fly   479 TCRMQIKCDKCNQSFSTLTSLTKHKKF--------CDS------------------TGPGPYRNQ 517
            |.....||::|.::|::.|:||.||:.        |:.                  ||..||:.:
Human   384 TGEKPYKCEECGKAFNSSTNLTAHKRIHTREKPYTCEDRGRAFGLSTNLNEYKKIHTGDKPYKCK 448

  Fly   518 HVNR---HHQHPHQHPLPHQPHLAATATSTCPAPPRESSE-SSSSAAAAAVAAMSTPPNPFLMFR 578
            ...:   |..|.::|...|        |...|...::..: .:||::.|....:.|...||....
Human   449 ECGKAFIHSLHLNKHEKIH--------TGKKPYKCKQCGKVITSSSSFAKHKRIHTGEKPFECLE 505

  Fly   579 TAPSF------------FPGFPPY-----------------------GFPPFLPQNPLHPTNIPM 608
            ...:|            ..|..||                       |..|:..:.
Human   506 CGKAFTSSTTLTKHRRIHTGEKPYTCEVCGKAFRQSAILYVHRRIHTGEKPYTCEE--------- 561

  Fly   609 FFSKNPMDLGCGGPEITSPVSAFDQ-------------KLPF-----GFLKGENSESQAYDKVTE 655
                      ||        ..|.|             :.|:     |...|..::...:.|:..
Human   562 ----------CG--------KTFRQSANLYVHRRIHTGEKPYKCEECGKAFGRYTDLNQHKKIHT 608

  Fly   656 KELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEE-------QDDMKQEPER 713
            .|.::|.||.           |::....:.|:.:.|:.......|.||       ..|:.|..:.
Human   609 GEKLYKCEEC-----------GKDFVWYTDLNQQKKIYTGEKPYKCEECGKAFAPSTDLNQHTKI 662

  Fly   714 VSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPR 778
            ::.....:.|:..|:...............|:.|.....|.|..:.|       .||..||   |
Human   663 LTGEQSYKCEECGKAFGWSIALNQHKKIHTGEKPYKCEECGKAFSRS-------RNLTTHR---R 717

  Fly   779 LHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEG 843
            :|    .|.:|.|......|...||:...:|                    ....|.:|....|.
Human   718 VH----TREKPYKCEDRGRSFGWSTNLNEYK--------------------KIHTGDKLYKCKEC 758

  Fly   844 GAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAAS 908
            |.|...:                   :|...|    |:|:....|:.|:..|:     ::..::|
Human   759 GKVFKQS-------------------SHLNRH----EKIHTGKKPYKCKECGK-----VITSSSS 795

  Fly   909 AAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAF 972
            .|..||              :.|.:: :.|..|||.|..|..||:|.|.||||:||.|:.|.:||
Human   796 FAKHKR--------------IHTGEKPFKCLECGKAFTSSTTLTKHRRIHTGEKPYTCEECGKAF 846

  Fly   973 SISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE--------GNNFRDS 1024
            ..|:.|..| |.||..|:|:.|..|.::|.|..||..|.|.|..|        |..||.|
Human   847 RQSAILYVH-RRIHTGEKPYTCGECGKTFRQSANLYAHKKIHTGEKPYTCGDCGKTFRQS 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	15/93 (16%)
		COG5048	935..>1028	CDD:227381	42/98 (43%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368
		COG5048	93..492	CDD:227381	84/310 (27%)
		C2H2 Zn finger	111..131	CDD:275368
		C2H2 Zn finger	139..159	CDD:275368
		zf-H2C2_2	151..176	CDD:290200
		C2H2 Zn finger	167..187	CDD:275368
		C2H2 Zn finger	223..243	CDD:275368	3/19 (16%)
		zf-H2C2_2	235..257	CDD:290200	3/24 (13%)
		C2H2 Zn finger	251..271	CDD:275368	5/21 (24%)
		C2H2 Zn finger	279..299	CDD:275368	7/20 (35%)
		zf-H2C2_2	292..316	CDD:290200	11/24 (46%)
		C2H2 Zn finger	307..327	CDD:275368	9/20 (45%)
		zf-H2C2_2	319..344	CDD:290200	13/25 (52%)
		C2H2 Zn finger	335..355	CDD:275368	10/19 (53%)
		zf-H2C2_2	347..372	CDD:290200	11/24 (46%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		zf-H2C2_2	375..400	CDD:290200	9/25 (36%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		COG5048	442..885	CDD:227381	112/565 (20%)
		C2H2 Zn finger	447..467	CDD:275368	3/19 (16%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		zf-H2C2_2	487..512	CDD:290200	5/24 (21%)
		C2H2 Zn finger	503..523	CDD:275368	1/19 (5%)
		zf-H2C2_2	516..540	CDD:290200	3/23 (13%)
		C2H2 Zn finger	531..551	CDD:275368	0/19 (0%)
		zf-H2C2_2	544..568	CDD:290200	5/50 (10%)
		C2H2 Zn finger	559..579	CDD:275368	4/46 (9%)
		zf-H2C2_2	571..596	CDD:290200	2/24 (8%)
		C2H2 Zn finger	587..607	CDD:275368	3/19 (16%)
		C2H2 Zn finger	615..634	CDD:275368	4/29 (14%)
		C2H2 Zn finger	643..663	CDD:275368	4/19 (21%)
		C2H2 Zn finger	671..691	CDD:275368	2/19 (11%)
		zf-H2C2_2	683..708	CDD:290200	4/24 (17%)
		C2H2 Zn finger	699..719	CDD:275368	8/29 (28%)
		C2H2 Zn finger	755..775	CDD:275368	6/42 (14%)
		zf-H2C2_2	767..789	CDD:290200	7/30 (23%)
		C2H2 Zn finger	783..803	CDD:275368	6/38 (16%)
		zf-H2C2_2	795..820	CDD:290200	10/38 (26%)
		C2H2 Zn finger	811..831	CDD:275368	10/19 (53%)
		zf-H2C2_2	824..848	CDD:290200	14/23 (61%)
		C2H2 Zn finger	839..859	CDD:275368	8/20 (40%)
		zf-H2C2_2	852..876	CDD:290200	10/24 (42%)
		C2H2 Zn finger	867..887	CDD:275368	8/19 (42%)
		C2H2 Zn finger	895..915	CDD:275368	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000