DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF431

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_011526052.1	Gene:	ZNF431 / 170959	HGNCID:	20809	Length:	593	Species:	Homo sapiens

Alignment Length:	682	Identity:	143/682 - (20%)
Similarity:	211/682 - (30%)	Gaps:	307/682 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   344 CDKVYPDL--DLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKV 406
            ||| |..:  ..|:.:.....|..:..|.||:|...||....|.:|:.| |.....|.||.|.|.
Human   195 CDK-YVKVFHKFLNANRHKTRHTGKKPFKCKKCGKSFCMLLHLSQHKRI-HIRENSYQCEECGKA 257

  Fly   407 FCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLC 471
            |...|.|.||.| .|.|.:...|.||||.|..||.|..|:.||:..||:.||.|.||:.:.|:|.
Human   258 FKWFSTLTRHKR-IHTGEKPFKCEECGKAFKQSSTLTTHKIIHTGEKPYRCEECGKAFNRSSHLT 321

  Fly   472 RHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPH 536
            .||.:| |.....||::|.::|:..::|:.||..  ..|..||:.:..::
Human   322 THKIIH-TGEKPYKCEECGKAFNQSSTLSTHKFI--HAGEKPYKCEECDK--------------- 368

  Fly   537 LAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPL 601

Human   369 ----------------------------------------------------------------- 368

  Fly   602 HPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKL 666
                                        ||::   |.:|             |:.:::...|:..
Human   369 ----------------------------AFNR---FSYL-------------TKHKIIHTGEKSY 389

  Fly   667 KKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDI 731
            |.|...:.|      :.||...|.|                     |:.|
Human   390 KCEECGKGF------NWSSTLTKHK---------------------RIHT--------------- 412

  Fly   732 MSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSH 796
                        |:.|....:|.|....|       .||..|:.:
Human   413 ------------GEKPYKCEVCGKAFNES-------SNLTTHKMI-------------------- 438

  Fly   797 SSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSAL 861
                       |.|..|............||        :|::                  |..:
Human   439 -----------HTGEKPYKCEECGKAFNRSP--------QLTA------------------HKII 466

  Fly   862 ASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSV 926
            .:|..                     |:.|:..|:                       .||..|:
Human   467 HTGEK---------------------PYKCEECGK-----------------------AFSQSSI 487

  Fly   927 VGLKTKDR-------YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRN 984
              |.|..|       |.|:.|||.|.||:|||:|...||||:.|.|:.|.:||:.||.|.:| |.
Human   488 --LTTHKRIHTGEKPYKCEECGKAFNRSSNLTKHKIIHTGEKSYKCEECGKAFNQSSTLTKH-RK 549

  Fly   985 IHNKERPFRCELCDRSFGQQTNLDRHVKKHES 1016
            ||.:::|:.||.||.:|.|.:||   :|::.|
Human   550 IHTRQKPYNCEECDNTFNQSSNL---IKQNNS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/20 (25%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	38/87 (44%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	19/41 (46%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	39/82 (48%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	9/19 (47%)
ZNF431	XP_011526052.1	KRAB	51..112	CDD:214630
		KRAB	51..90	CDD:279668
		zf-H2C2_2	209..230	CDD:290200	5/20 (25%)
		COG5048	218..570	CDD:227381	133/645 (21%)
		C2H2 Zn finger	223..243	CDD:275368	8/20 (40%)
		C2H2 Zn finger	251..271	CDD:275368	10/20 (50%)
		zf-H2C2_2	264..288	CDD:290200	12/24 (50%)
		C2H2 Zn finger	279..299	CDD:275368	10/19 (53%)
		zf-H2C2_2	292..316	CDD:290200	11/23 (48%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		zf-H2C2_2	319..344	CDD:290200	9/25 (36%)
		C2H2 Zn finger	335..355	CDD:275368	6/21 (29%)
		C2H2 Zn finger	363..383	CDD:275368	5/143 (3%)
		zf-H2C2_2	375..399	CDD:290200	6/42 (14%)
		C2H2 Zn finger	391..411	CDD:275368	7/46 (15%)
		zf-H2C2_2	404..427	CDD:290200	8/70 (11%)
		C2H2 Zn finger	419..439	CDD:275368	6/57 (11%)
		zf-H2C2_2	431..456	CDD:290200	6/55 (11%)
		C2H2 Zn finger	447..467	CDD:275368	4/45 (9%)
		zf-H2C2_2	460..484	CDD:290200	7/85 (8%)
		C2H2 Zn finger	475..495	CDD:275368	8/44 (18%)
		zf-H2C2_2	488..512	CDD:290200	9/23 (39%)
		C2H2 Zn finger	503..523	CDD:275368	11/19 (58%)
		zf-H2C2_2	515..540	CDD:290200	13/24 (54%)
		C2H2 Zn finger	531..551	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000