DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF883

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001094808.1	Gene:	ZNF883 / 169834	HGNCID:	27271	Length:	379	Species:	Homo sapiens

Alignment Length:	691	Identity:	130/691 - (18%)
Similarity:	180/691 - (26%)	Gaps:	351/691 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 CEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSK 405
            |..|.|.|..|..|..|  ...|..:..:.||.|...|.....|::|:.| |...:.|.|..|.|
Human    15 CTECGKGYTCLASLTQH--QKTHIGEKPYECKICGKSFTRNSNLVQHQRI-HTGEKPYECNECGK 76

  Fly   406 VFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNL 470
            .|...:||.:|.|. |.|.:.:.|.||.|||...|.|:.|:.||:..||:.|..|.||::..|.|
Human    77 AFSQSTNLIQHQRV-HTGEKPYECNECEKTFSHRSSLRNHERIHTGEKPYPCNECGKAFSHISAL 140

  Fly   471 CRHKRMHATCRMQIKCDKCNQSFSTLTSLTKH----------------KKFCDSTGPGPYRNQHV 519
            .:|.|:| |.:...:|.:|.::||..|.|.:|                |.||.||.
Human   141 TQHHRIH-TGKKPYECTECGKTFSRSTHLIEHQGIHSEEKSYQCKQCRKVFCHSTS--------- 195

  Fly   520 NRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFF 584
            ...||..|....|::.:....|.|..||
Human   196 LIRHQRTHTGEKPYECNECGKAFSHTPA------------------------------------- 223

  Fly   585 PGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQA 649
                      |:....:|.
Human   224 ----------FIQHQRIHT---------------------------------------------- 232

  Fly   650 YDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERV 714

Human   233 ----------------------------------------------------------------- 232

  Fly   715 STPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRL 779
                                         |:.|.:.:.|     |..|
Human   233 -----------------------------GEKPYECNAC-----GKAF----------------- 246

  Fly   780 HEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGG 844
                            :.||..:..|::|.|..|
Human   247 ----------------NRSAHLTEHQRTHTGEKP------------------------------- 264

  Fly   845 AVPTMAAAAFAADHSALASGPTLPQ-THPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAAS 908
                         :.....|.|..: ||.|.|..:                            .|
Human   265 -------------YVCKECGKTFSRSTHLTEHLKI----------------------------HS 288

  Fly   909 AAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFS 973
            ...|                      |.|..|.|:|....:|.||.||||||:||.|..|.::||
Human   289 CVKP----------------------YQCNECQKLFCYRTSLIRHQRTHTGEKPYQCNECGKSFS 331

  Fly   974 ISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKH 1014
            :||.|.:|.| ||.:|||::|..|...|...|:|.||.|.|
Human   332 LSSALTKHKR-IHTRERPYQCTKCGDVFCHSTSLIRHQKTH 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/21 (33%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	7/33 (21%)
		PTZ00121	<641..>728	CDD:173412	0/86 (0%)
		COG5048	935..>1028	CDD:227381	39/80 (49%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF883	NP_001094808.1	COG5048	11..377	CDD:227381	130/691 (19%)
		C2H2 Zn finger	15..35	CDD:275368	7/21 (33%)
		zf-H2C2_2	27..52	CDD:290200	7/26 (27%)
		C2H2 Zn finger	43..63	CDD:275368	7/20 (35%)
		zf-H2C2_2	55..80	CDD:290200	9/25 (36%)
		C2H2 Zn finger	71..91	CDD:275368	8/20 (40%)
		zf-H2C2_2	83..108	CDD:290200	12/25 (48%)
		C2H2 Zn finger	99..119	CDD:275368	9/19 (47%)
		zf-H2C2_2	111..136	CDD:290200	10/24 (42%)
		C2H2 Zn finger	127..147	CDD:275368	8/19 (42%)
		zf-H2C2_2	139..164	CDD:290200	8/25 (32%)
		C2H2 Zn finger	155..175	CDD:275368	7/19 (37%)
		C2H2 Zn finger	183..203	CDD:275368	7/28 (25%)
		zf-H2C2_2	195..220	CDD:290200	5/33 (15%)
		C2H2 Zn finger	211..231	CDD:275368	5/66 (8%)
		C2H2 Zn finger	239..259	CDD:275368	6/57 (11%)
		zf-H2C2_2	251..276	CDD:290200	6/68 (9%)
		C2H2 Zn finger	267..287	CDD:275368	6/47 (13%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	307..331	CDD:290200	13/23 (57%)
		C2H2 Zn finger	323..343	CDD:275368	9/20 (45%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000