DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF540

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001165696.1	Gene:	ZNF540 / 163255	HGNCID:	25331	Length:	660	Species:	Homo sapiens

Alignment Length:	761	Identity:	159/761 - (20%)
Similarity:	236/761 - (31%)	Gaps:	300/761 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 SDRDNGSLYSGDEFSKDKK--NSSLIREGDID--------------------------FTDDENG 336
            :||...|..........:|  :|.|::.|.||                          .|.:::
Human   151 TDRKRPSFTLNQRIHNSEKSCDSHLVQHGKIDSDVKHDCKECGSTFNNVYQLTLHQKIHTGEKS- 214

  Fly   337 FDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCE 401
              .:||.|.||:.....|..|  ...|..:..:.|::|...|...|.|.:|:.| |...:.|.|:
Human   215 --CKCEKCGKVFSHSYQLTLH--QRFHTGEKPYECQECGKTFTLYPQLNRHQKI-HTGKKPYMCK 274

  Fly   402 NCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQ 466
            .|.|.|.....|.:|.| .|.|.:.:.|.||||.|......|:|:.||:..||:.|:.|.||::.
Human   275 KCDKGFFSRLELTQHKR-IHTGKKSYECKECGKVFQLIFYFKEHERIHTGKKPYECKECGKAFSV 338

  Fly   467 FSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPY-----------RNQHVN 520
            ...|.||:::|...: ..:|.:|.::|.....||:|::  ...|..||           |.| :|
Human   339 CGQLTRHQKIHTGVK-PYECKECGKTFRLSFYLTEHRR--THAGKKPYECKECGKSFNVRGQ-LN 399

  Fly   521 RHHQ-HPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFF 584
            ||.. |....|.         |...|     |.:.|.|..                 .|......
Human   400 RHKTIHTGIKPF---------ACKVC-----EKAFSYSGD-----------------LRVHSRIH 433

  Fly   585 PGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQA 649
            .|..||....                        ||...:...|....|:|..|....|..|.
Human   434 TGEKPYECKE------------------------CGKAFMLRSVLTEHQRLHTGVKPYECKEC-- 472

  Fly   650 YDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERV 714
                                       |:....||.:.:..|:           ..|:|
Human   473 ---------------------------GKTFRVRSQISLHKKI-----------HTDVK------ 493

  Fly   715 STPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRL 779
                                            |.....|.|.....|:       |..|:   |:
Human   494 --------------------------------PYKCVRCGKTFRFGFY-------LTEHQ---RI 516

  Fly   780 HEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGG 844
            |..|    :|.|.::...:.....:.|.|
Human   517 HTGE----KPYKCKECGKAFIRRGNLKEH------------------------------------ 541

  Fly   845 AVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGG----RRGIEALLAG 905
                      ...||.|.                         |:.|:..|    |||
Human   542 ----------LKIHSGLK-------------------------PYDCKECGKSFSRRG------- 564

  Fly   906 AASAAAPKRPLPPVKFSAGSVV--GLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYC 968
                          :|:....:  |:|.   |.||.|||.|.||.:|..|.|.||||:||.||.|
Human   565 --------------QFTEHQKIHTGVKP---YKCKECGKAFSRSVDLRIHQRIHTGEKPYECKQC 612

  Fly   969 DRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKH 1014
            .:||.::|:|..|.| ||..|:|:.|::|.::|.|.::|.:|.|.|
Human   613 GKAFRLNSHLTEHQR-IHTGEKPYECKVCRKAFRQYSHLYQHQKTH 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/21 (33%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	8/86 (9%)
		COG5048	935..>1028	CDD:227381	39/80 (49%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF540	NP_001165696.1	KRAB	6..66	CDD:214630
		C2H2 Zn finger	189..209	CDD:275368	0/19 (0%)
		C2H2 Zn finger	217..237	CDD:275368	7/21 (33%)
		COG5048	241..620	CDD:227381	125/626 (20%)
		C2H2 Zn finger	245..265	CDD:275368	7/20 (35%)
		C2H2 Zn finger	273..293	CDD:275368	7/20 (35%)
		C2H2 Zn finger	301..321	CDD:275368	8/19 (42%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		C2H2 Zn finger	357..377	CDD:275368	6/21 (29%)
		C2H2 Zn finger	385..405	CDD:275368	5/20 (25%)
		C2H2 Zn finger	413..433	CDD:275368	5/41 (12%)
		C2H2 Zn finger	441..461	CDD:275368	4/43 (9%)
		C2H2 Zn finger	469..489	CDD:275368	5/59 (8%)
		C2H2 Zn finger	497..517	CDD:275368	6/29 (21%)
		C2H2 Zn finger	525..545	CDD:275368	2/65 (3%)
		C2H2 Zn finger	553..573	CDD:275368	6/40 (15%)
		C2H2 Zn finger	581..601	CDD:275368	11/19 (58%)
		C2H2 Zn finger	609..629	CDD:275368	9/20 (45%)
		zf-H2C2_2	621..646	CDD:316026	10/25 (40%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000