DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF433

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_011526027.1	Gene:	ZNF433 / 163059	HGNCID:	20811	Length:	684	Species:	Homo sapiens

Alignment Length:	729	Identity:	168/729 - (23%)
Similarity:	257/729 - (35%)	Gaps:	219/729 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 CEVCDKVYPDL----DLLDDHL---IGAHHFKQDEFPCKQCALRFCHRPL-----LIKHEAISHN 393
            ||  ..||.::    ..|:.|:   .|...::..|:..|....::|.:|.     :..||. :|:
Human   115 CE--SSVYGEVGSAHSSLNRHIRDDTGHKAYEYQEYGQKPYKCKYCKKPFNCLSSVQTHER-AHS 176

  Fly   394 NIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACE 458
            ..:.|.||.|.|.|...|||||| |..|.|...:.|..|||.....|....|:..|:..||:.|:
Human   177 GRKLYVCEECGKTFISHSNLQRH-RIMHRGDGPYKCKFCGKALMFLSLYLIHKRTHTGEKPYQCK 240

  Fly   459 VCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYR-------- 515
            .|.||::..|:|..|:|.| |.....||::|.::|.:.|.|..||:  ..||..||.
Human   241 QCGKAFSHSSSLRIHERTH-TGEKPYKCNECGKAFHSSTCLHAHKR--THTGEKPYECKQCGKAF 302

  Fly   516 -NQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRT 579
             :.|..:.|:..|....|::......|.. ||:..|....:.|
Human   303 SSSHSFQIHERTHTGEKPYECKECGKAFK-CPSSVRRHERTHS---------------------- 344

  Fly   580 APSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDL-GCGGPEITSPVSAFDQKLPFGFLKGE 643
                                           .|.|.:. .||  ::.|.:::|...|  |...||
Human   345 -------------------------------RKKPYECKHCG--KVLSYLTSFQNHL--GMHTGE 374

  Fly   644 NSES--------------QAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLED 694
            .|..              |.::|....|..:|..:                        .||..:
Human   375 ISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQ------------------------CGKAFN 415

  Fly   695 TRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKR-SA 758
            :.:..:..|:....::|.     :.:|.....:|..::.|.....|   |:.|.....|.|. |.
Human   416 SSSSFRYHERTHTGEKPY-----ECKQCGKAFRSASLLQTHGRTHT---GEKPYACKECGKPFSN 472

  Fly   759 GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGL 823
            .|||               ::||         :|.:.....|.       ||...|   .:.|.|
Human   473 FSFF---------------QIHE---------RMHREEKPYEC-------KGYGKT---FSLPSL 503

  Fly   824 TPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFP 888
            . .....|..||:.....:.|       .:|....|....|    :||.
Human   504 F-HRHERTHTGGKTYECKQCG-------RSFNCSSSFRYHG----RTHT---------------- 540

  Fly   889 FLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRH 953
                  |.:..|....|.|..:|.:     ::....:..|.|.   |.||.|||.|..:::|..|
Human   541 ------GEKPYECKQCGKAFRSASQ-----LQIHGRTHTGEKP---YECKQCGKAFGSASHLQMH 591

  Fly   954 LRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE- 1017
            .||||||:||.||.|.::|..:|.||.|.|. |..|:|::|:.|.::||..:||.||.:.|..|
Human   592 GRTHTGEKPYECKQCGKSFGCASRLQMHGRT-HTGEKPYKCKQCGKAFGCPSNLRRHGRTHTGEK 655

  Fly  1018 -------GNNFRDS 1024
                   |..||.|
Human   656 PYKCNQCGKVFRCS 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/28 (25%)
		C2H2 Zn finger	371..392	CDD:275368	5/25 (20%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	12/20 (60%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	10/17 (59%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	12/100 (12%)
		COG5048	935..>1028	CDD:227381	43/98 (44%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF433	XP_011526027.1	KRAB	18..>60	CDD:214630
		KRAB	18..57	CDD:279668
		C2H2 Zn finger	145..175	CDD:275368	6/30 (20%)
		C2H2 Zn finger	183..203	CDD:275368	12/20 (60%)
		COG5048	208..614	CDD:227381	117/574 (20%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		zf-H2C2_2	227..248	CDD:290200	8/20 (40%)
		C2H2 Zn finger	239..259	CDD:275368	8/19 (42%)
		zf-H2C2_2	251..276	CDD:290200	9/25 (36%)
		C2H2 Zn finger	267..287	CDD:275368	7/21 (33%)
		zf-H2C2_2	283..304	CDD:290200	6/22 (27%)
		C2H2 Zn finger	295..315	CDD:275368	2/19 (11%)
		zf-H2C2_2	307..332	CDD:290200	4/25 (16%)
		C2H2 Zn finger	323..343	CDD:275368	4/20 (20%)
		C2H2 Zn finger	351..371	CDD:275368	6/23 (26%)
		C2H2 Zn finger	379..399	CDD:275368	2/19 (11%)
		zf-H2C2_2	391..416	CDD:290200	6/48 (13%)
		C2H2 Zn finger	407..427	CDD:275368	3/43 (7%)
		zf-H2C2_2	419..444	CDD:290200	3/29 (10%)
		C2H2 Zn finger	435..455	CDD:275368	3/19 (16%)
		C2H2 Zn finger	463..483	CDD:275368	8/43 (19%)
		C2H2 Zn finger	491..511	CDD:275368	5/30 (17%)
		C2H2 Zn finger	519..539	CDD:275368	4/30 (13%)
		C2H2 Zn finger	547..567	CDD:275368	3/24 (13%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	603..623	CDD:275368	9/20 (45%)
		C2H2 Zn finger	631..651	CDD:275368	8/19 (42%)
		zf-H2C2_2	643..668	CDD:290200	8/24 (33%)
		C2H2 Zn finger	659..679	CDD:275368	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000