DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF600

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001308795.1 Gene:ZNF600 / 162966 HGNCID:30951 Length:791 Species:Homo sapiens


Alignment Length:762 Identity:182/762 - (23%)
Similarity:265/762 - (34%) Gaps:200/762 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   292 SSAPSDDRSDR--DNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLL 354
            |.|||...|.|  ....::..:.:..:..||||:.:....:..:::   .:|....|.:....||
Human   185 SDAPSVSTSQRISPRPQIHISNNYGNNSPNSSLLPQKQEVYMREKS---FQCNESGKAFNCSSLL 246

  Fly   355 DDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRA 419
            ..|.|  .|....::.|..|...|.|:..|..| ...|...:.|.|..|.|.|...|:|..| |.
Human   247 RKHQI--PHLGDKQYKCDVCGKLFNHKQYLTCH-CRCHTGEKPYKCNECGKSFSQVSSLTCH-RR 307

  Fly   420 YHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQI 484
            .|...:.|.|.||||.||.:|.|..|:.||:..||:.|..|.||:.|.|||.||:|:| |.....
Human   308 LHTAVKSHKCNECGKIFGQNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIH-TGEKPY 371

  Fly   485 KCDKCNQSFSTLTSLTKHKKFCDSTGPGPYR----------NQHVNRHHQ-HPHQHPLPHQPHLA 538
            ||::|::.||..::|..||:.  .||..||:          |..:.||.: |            .
Human   372 KCEECDKVFSRKSTLESHKRI--HTGEKPYKCKVCDTAFTWNSQLARHKRIH------------T 422

  Fly   539 ATATSTCPAPPRESSESSS-----------SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGF 592
            ...|..|....:..|..||           .:....|...:...|..|:..|.            
Human   423 GEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSYKCKVCDKAFAWNSHLVRHTR------------ 475

  Fly   593 PPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKE 657
                    :|....|...::      ||        ..|.|.......|..::..|.| |..|.|
Human   476 --------IHSGGKPYKCNE------CG--------KTFGQNSDLLIHKSIHTGEQPY-KYEECE 517

  Fly   658 LVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQA 722
            .||.....|:...::...|                                 :|.:....|:..|
Human   518 KVFSCGSTLETHKIIHTGE---------------------------------KPYKCKVCDKAFA 549

  Fly   723 EDD--RKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAE 785
            ...  .|...|.|          |:.|...:.|.|       |......|..||   |:|..|  
Human   550 CHSYLAKHTRIHS----------GEKPYKCNECSK-------TFRLRSYLASHR---RVHSGE-- 592

  Fly   786 RGQPLKMRKSHSSAESSTSQKS--------HKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSE 842
              :|.|.    :....:.||:|        |.|..|......  |.|.|..|.......| .|.|
Human   593 --KPYKC----NECSKTFSQRSYLHCHRRLHSGEKPYKCNEC--GKTFSHKPSLVHHRRL-HTGE 648

  Fly   843 GGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAA 907
            .....|:...||.. :|.||       .|...|        .:..|:.|...|:           
Human   649 KSYKCTVCDKAFVR-NSYLA-------RHTRIH--------TAEKPYKCNECGK----------- 686

  Fly   908 SAAAPKRPLPPVKFSAGSVVGLKTK-----DRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKY 967
                        .|:..|.:.|..:     ..|.|:.|.|||.|.::|.||.|.|.|::||.||.
Human   687 ------------AFNQQSQLSLHHRIHAGEKLYKCETCDKVFSRKSHLKRHRRIHPGKKPYKCKV 739

  Fly   968 CDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKH 1014
            ||:.|...|:|::|. .:|..|:|::|..|.::|.:|:.|..|...|
Human   740 CDKTFGSDSHLKQHT-GLHTGEKPYKCNECGKAFSKQSTLIHHQAVH 785

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 6/21 (29%)
C2H2 Zn finger 371..392 CDD:275368 6/20 (30%)
SFP1 <391..479 CDD:227516 38/87 (44%)
C2H2 Zn finger 400..421 CDD:275368 8/20 (40%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 7/17 (41%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 11/19 (58%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 13/88 (15%)
COG5048 935..>1028 CDD:227381 33/80 (41%)
zf-C2H2 935..957 CDD:395048 11/21 (52%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 12/23 (52%)
C2H2 Zn finger 965..986 CDD:275368 8/20 (40%)
C2H2 Zn finger 994..1014 CDD:275368 6/19 (32%)
ZNF600NP_001308795.1 KRAB 24..71 CDD:214630
KRAB 24..60 CDD:279668
COG5048 <154..503 CDD:227381 93/373 (25%)
C2H2 Zn finger 233..253 CDD:275368 6/21 (29%)
C2H2 Zn finger 261..281 CDD:275368 6/20 (30%)
zf-H2C2_2 273..298 CDD:290200 8/25 (32%)
C2H2 Zn finger 289..309 CDD:275368 8/20 (40%)
C2H2 Zn finger 317..337 CDD:275368 10/19 (53%)
zf-H2C2_2 329..354 CDD:290200 10/24 (42%)
COG5048 341..748 CDD:227381 122/559 (22%)
C2H2 Zn finger 345..365 CDD:275368 11/19 (58%)
zf-H2C2_2 357..382 CDD:290200 11/25 (44%)
C2H2 Zn finger 373..393 CDD:275368 7/21 (33%)
zf-H2C2_2 386..409 CDD:290200 7/24 (29%)
C2H2 Zn finger 401..421 CDD:275368 3/19 (16%)
zf-H2C2_2 414..438 CDD:290200 5/35 (14%)
C2H2 Zn finger 429..449 CDD:275368 4/19 (21%)
C2H2 Zn finger 457..477 CDD:275368 4/39 (10%)
C2H2 Zn finger 485..505 CDD:275368 5/33 (15%)
C2H2 Zn finger 513..533 CDD:275368 5/19 (26%)
zf-H2C2_2 526..550 CDD:290200 4/56 (7%)
C2H2 Zn finger 541..561 CDD:275368 3/19 (16%)
C2H2 Zn finger 569..589 CDD:275368 7/29 (24%)
zf-H2C2_2 581..606 CDD:290200 8/35 (23%)
C2H2 Zn finger 597..617 CDD:275368 3/23 (13%)
C2H2 Zn finger 625..645 CDD:275368 5/22 (23%)
C2H2 Zn finger 653..673 CDD:275368 7/27 (26%)
zf-H2C2_2 665..690 CDD:290200 8/62 (13%)
C2H2 Zn finger 681..701 CDD:275368 5/42 (12%)
zf-C2H2 707..729 CDD:278523 11/21 (52%)
C2H2 Zn finger 709..729 CDD:275368 10/19 (53%)
zf-H2C2_2 721..744 CDD:290200 12/22 (55%)
C2H2 Zn finger 737..757 CDD:275368 8/20 (40%)
zf-H2C2_2 749..773 CDD:290200 7/24 (29%)
C2H2 Zn finger 765..785 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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