DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF569

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_006723109.1	Gene:	ZNF569 / 148266	HGNCID:	24737	Length:	710	Species:	Homo sapiens

Alignment Length:	766	Identity:	177/766 - (23%)
Similarity:	259/766 - (33%)	Gaps:	277/766 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 SDDRSDRDNGSLYSGDEFSK------DKKNS--SLIREGDIDFTDDENGF----------DIRCE 342
            ||....|.|  ||..|.|.|      |..|:  .|:|:...::.:....:          ..:|.
Human   151 SDFFPSRHN--LYEYDLFGKCLEHNFDCHNNVKCLMRKEHCEYNEPVKSYGNSSSHFVITPFKCN 213

  Fly   343 VCDKVY-PDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKV 406
            .|.|.: ..|||: .||  ..|..:..:.|..|...|.|:..||||..| |:..:.|.|..|.|.
Human   214 HCGKGFNQTLDLI-RHL--RIHTGEKPYECSNCRKAFSHKEKLIKHYKI-HSREQSYKCNECGKA 274

  Fly   407 FCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLC 471
            |...|||.||.| .|.|.:.:.|.||.|:|...|.|..|:.||:..||:.|..|.||::|..:|.
Human   275 FIKMSNLIRHQR-IHTGEKPYACKECEKSFSQKSNLIDHEKIHTGEKPYECNECGKAFSQKQSLI 338

  Fly   472 RHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQ--------------HVNRH 522
            .|:::| |......|::|.::|..:.||..|.:  ..||..||:..              ||..|
Human   339 AHQKVH-TGEKPYACNECGKAFPRIASLALHMR--SHTGEKPYKCDKCGKAFSQFSMLIIHVRIH 400

  Fly   523 HQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGF 587
                               |...|....|..::.|.::|..|...|               ..|.
Human   401 -------------------TGEKPYECNECGKAFSQSSALTVHMRS---------------HTGE 431

  Fly   588 PPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDK 652
            .||                                |......||..|..|          ..:.|
Human   432 KPY--------------------------------ECKECRKAFSHKKNF----------ITHQK 454

  Fly   653 VTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTP 717
            :..:|..::..|.           |:.....|:|        .|:              :|:.|
Human   455 IHTREKPYECNEC-----------GKAFIQMSNL--------VRH--------------QRIHT- 485

  Fly   718 DQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEF 782
                                      |:.|.   ||::  .|..|:  .:.||:.|.   ::|..
Human   486 --------------------------GEKPY---ICKE--CGKAFS--QKSNLIAHE---KIHSG 514

  Fly   783 EA-----ERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSE 842
            |.     |.|:....:::.     .|.||.|.|..|                        ...:|
Human   515 EKPYECNECGKAFSQKQNF-----ITHQKVHTGEKP------------------------YDCNE 550

  Fly   843 GGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSG-FPFLCQPGGRRGIEALLAGA 906
            .|       .||    |.:||             |.|.....:| .|:.|...|:
Human   551 CG-------KAF----SQIAS-------------LTLHLRSHTGEKPYECDKCGK---------- 581

  Fly   907 ASAAAPKRPLPPVKFSAGSVVGLKTKDR-----YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCK 966
                         .||..|::.|..:..     |.|..|||.|.:..:|..|:|.||||:||.|.
Human   582 -------------AFSQCSLLNLHMRSHTGEKPYVCNECGKAFSQRTSLIVHMRGHTGEKPYECN 633

  Fly   967 YCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            .|.:|||.||:|..|:|. |..|:||.|..|.::|.|.::|..|::||..|
Human   634 KCGKAFSQSSSLTIHIRG-HTGEKPFDCSKCGKAFSQISSLTLHMRKHTGE 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	8/22 (36%)
		C2H2 Zn finger	371..392	CDD:275368	9/20 (45%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	9/17 (53%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	9/86 (10%)
		COG5048	935..>1028	CDD:227381	38/83 (46%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF569	XP_006723109.1	KRAB	32..86	CDD:214630
		COG5048	<200..368	CDD:227381	58/173 (34%)
		C2H2 Zn finger	212..232	CDD:275368	8/22 (36%)
		C2H2 Zn finger	240..260	CDD:275368	9/20 (45%)
		C2H2 Zn finger	268..288	CDD:275368	10/20 (50%)
		COG5048	292..704	CDD:227381	132/618 (21%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		C2H2 Zn finger	352..372	CDD:275368	6/21 (29%)
		C2H2 Zn finger	380..400	CDD:275368	2/19 (11%)
		C2H2 Zn finger	408..428	CDD:275368	5/34 (15%)
		C2H2 Zn finger	436..456	CDD:275368	5/29 (17%)
		C2H2 Zn finger	464..484	CDD:275368	6/52 (12%)
		C2H2 Zn finger	492..512	CDD:275368	6/26 (23%)
		C2H2 Zn finger	520..540	CDD:275368	5/24 (21%)
		C2H2 Zn finger	548..568	CDD:275368	9/43 (21%)
		C2H2 Zn finger	576..596	CDD:275368	6/42 (14%)
		C2H2 Zn finger	604..624	CDD:275368	8/19 (42%)
		C2H2 Zn finger	632..652	CDD:275368	10/20 (50%)
		C2H2 Zn finger	660..680	CDD:275368	6/19 (32%)
		C2H2 Zn finger	688..708	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910