DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF681

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_612143.2 Gene:ZNF681 / 148213 HGNCID:26457 Length:645 Species:Homo sapiens


Alignment Length:716 Identity:145/716 - (20%)
Similarity:210/716 - (29%) Gaps:350/716 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   302 RDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQ 366
            ||  .||..:|.||....||.|....|..| .||.:  :.|.|||.:.....|..|.|.....|.
Human   250 RD--KLYKREECSKAFNLSSHITTHTIIHT-GENPY--KREECDKAFNQSLTLTTHKIIHTREKL 309

  Fly   367 DEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPE 431
            :|:  |:|...|.....|.:|:.| |...:.|.||.|.|.|...|:|.|| :..|.|.:.:.|.|
Human   310 NEY--KECGKAFNQSSHLTRHKII-HTGEKPYKCEECGKAFNQSSHLTRH-KIIHTGEKPYRCEE 370

  Fly   432 CGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTL 496
            |||.|..||.|..|:.||:..||:.||.|.||:.:.|:|.|||.:| |.....:|:||.::.:..
Human   371 CGKAFRQSSHLTTHKIIHTGEKPYKCEECGKAFNKSSHLTRHKSIH-TGEKPYQCEKCGKASNQS 434

  Fly   497 TSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAA 561
            ::||:||..  .|...||:.:.                                           
Human   435 SNLTEHKNI--HTEEKPYKCEE------------------------------------------- 454

  Fly   562 AAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITS 626
                                                                     ||      
Human   455 ---------------------------------------------------------CG------ 456

  Fly   627 PVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGK 691
              .||:|                :..:|..:.:...|:..|.|...:||      ::||:     
Human   457 --KAFNQ----------------FSNLTTHKRIHTGEKPYKCEECGKAF------NQSSI----- 492

  Fly   692 LEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKR 756
                                                                             
Human   493 ----------------------------------------------------------------- 492

  Fly   757 SAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASP 821
                         |..|:   |:|                      |.:||:|..........|.
Human   493 -------------LTTHK---RIH----------------------TGEKSYKCEECGKAFYRSS 519

  Fly   822 GLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSG 886
            .||                                :|..:.:|                      
Human   520 KLT--------------------------------EHKKIHTG---------------------- 530

  Fly   887 FPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLT 951
                                      ::|                   |:|:.|||.|..|::|.
Human   531 --------------------------EKP-------------------YTCEECGKAFNHSSHLA 550

  Fly   952 RHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHES 1016
            .|...||||:||.|:.|.:||:.||:|.||.| ||..|:|::||.|.::|.|.:||..|.|.|..
Human   551 THKVIHTGEKPYQCEECGKAFNQSSHLTRHKR-IHTGEKPYQCEKCGKAFNQSSNLTGHKKIHTG 614

  Fly  1017 E 1017
            |
Human   615 E 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 7/21 (33%)
C2H2 Zn finger 371..392 CDD:275368 6/20 (30%)
SFP1 <391..479 CDD:227516 38/87 (44%)
C2H2 Zn finger 400..421 CDD:275368 9/20 (45%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 7/17 (41%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 10/19 (53%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 8/86 (9%)
COG5048 935..>1028 CDD:227381 40/83 (48%)
zf-C2H2 935..957 CDD:395048 9/21 (43%)
C2H2 Zn finger 937..957 CDD:275368 8/19 (42%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 10/20 (50%)
C2H2 Zn finger 994..1014 CDD:275368 9/19 (47%)
ZNF681NP_612143.2 KRAB 4..64 CDD:214630
KRAB 4..43 CDD:279668
C2H2 Zn finger 144..164 CDD:275368
C2H2 Zn finger 176..192 CDD:275368
COG5048 198..610 CDD:227381 142/709 (20%)
C2H2 Zn finger 200..220 CDD:275368
C2H2 Zn finger 285..304 CDD:275368 7/18 (39%)
C2H2 Zn finger 313..332 CDD:275368 6/19 (32%)
zf-H2C2_2 324..349 CDD:290200 10/25 (40%)
C2H2 Zn finger 340..360 CDD:275368 9/20 (45%)
zf-H2C2_2 352..377 CDD:290200 11/25 (44%)
C2H2 Zn finger 368..388 CDD:275368 10/19 (53%)
zf-H2C2_2 380..404 CDD:290200 11/23 (48%)
C2H2 Zn finger 396..416 CDD:275368 10/19 (53%)
C2H2 Zn finger 424..444 CDD:275368 7/21 (33%)
zf-H2C2_2 436..461 CDD:290200 11/134 (8%)
C2H2 Zn finger 452..472 CDD:275368 6/143 (4%)
zf-H2C2_2 464..489 CDD:290200 6/30 (20%)
C2H2 Zn finger 480..500 CDD:275368 8/111 (7%)
zf-H2C2_2 493..517 CDD:290200 8/48 (17%)
C2H2 Zn finger 508..528 CDD:275368 4/51 (8%)
zf-H2C2_2 521..545 CDD:290200 11/122 (9%)
C2H2 Zn finger 536..556 CDD:275368 8/19 (42%)
zf-H2C2_2 548..573 CDD:290200 12/24 (50%)
C2H2 Zn finger 564..584 CDD:275368 10/20 (50%)
zf-H2C2_2 576..601 CDD:290200 12/25 (48%)
C2H2 Zn finger 592..612 CDD:275368 9/19 (47%)
C2H2 Zn finger 620..638 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 626..645
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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