DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF98

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001092096.1	Gene:	ZNF98 / 148198	HGNCID:	13174	Length:	572	Species:	Homo sapiens

Alignment Length:	699	Identity:	146/699 - (20%)
Similarity:	222/699 - (31%)	Gaps:	303/699 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 KVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDP 410
            ||:......:.|.||  |..:..|.||:|...||....|.:|:.| |:..:.|.|:.|.|.:.:.
Human   161 KVFHKFSNSNRHKIG--HTGKKSFKCKECEKSFCMLSHLAQHKRI-HSGEKPYKCKECGKAYNEA 222

  Fly   411 SNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKR 475
            |||..|.| .|.|.:.:.|.||||.|...|.|..|:.||:..||:.||.|.||:.|.:||..|||
Human   223 SNLSTHKR-IHTGKKPYKCEECGKAFNRLSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKR 286

  Fly   476 MHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAAT 540
            :| |.....||::|.::||..::||.||..  ..|..||:.:.
Human   287 IH-TGEKPYKCEECGRAFSQSSTLTAHKII--HAGEKPYKCEE---------------------- 326

  Fly   541 ATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTN 605

Human   327 ----------------------------------------------------------------- 326

  Fly   606 IPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEP 670
                         ||        .||.|.                ..:|..:::...|:..|.|.
Human   327 -------------CG--------KAFSQS----------------STLTTHKIIHTGEKFYKCEE 354

  Fly   671 LVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTP 735
            ..:||      ||.|
Human   355 CGKAF------SRLS-------------------------------------------------- 363

  Fly   736 PPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAE 800
                                             :|..|:   |:|..|    :|.|..:...:.:
Human   364 ---------------------------------HLTTHK---RIHSGE----KPYKCEECGKAFK 388

  Fly   801 SSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGP 865
            .|::..:||                     ....||.....|   |.:.|.:.|
Human   389 QSSTLTTHK---------------------RIHAGEKFYKCE---VCSKAFSRF----------- 418

  Fly   866 TLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR-GIEALLAGAASAAAPKRPLPPVKFSAGSVVGL 929
                :|.|.|    :.|:....|:.|:..|:. .:.:.|.........::|
Human   419 ----SHLTTH----KRIHTGEKPYKCEECGKAFNLSSQLTTHKIIHTGEKP-------------- 461

  Fly   930 KTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRC 994
                 |.|:.|||.|.:|:.|::|...||||:||.|:.|.:||:.||:|..| :.||..|:|::|
Human   462 -----YKCEECGKAFNQSSTLSKHKVIHTGEKPYKCEECGKAFNQSSHLTTH-KMIHTGEKPYKC 520

  Fly   995 ELCDRSFGQQTNLDRHVKKHESEG-------NNFRDSPSSSGIAEREEY 1036
            |.|.::|...:.|:||...|..|.       ||..|:     ||:..:|
Human   521 EECGKAFNNSSILNRHKMIHTGEKLYKPESCNNACDN-----IAKISKY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/16 (31%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	11/19 (58%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	9/86 (10%)
		COG5048	935..>1028	CDD:227381	39/99 (39%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	179..563	CDD:227381	139/676 (21%)
		C2H2 Zn finger	184..204	CDD:275368	8/20 (40%)
		zf-H2C2_2	196..220	CDD:290200	8/24 (33%)
		C2H2 Zn finger	212..232	CDD:275368	8/20 (40%)
		zf-H2C2_2	224..249	CDD:290200	12/25 (48%)
		C2H2 Zn finger	240..260	CDD:275368	9/19 (47%)
		zf-H2C2_2	252..277	CDD:290200	11/24 (46%)
		C2H2 Zn finger	268..288	CDD:275368	11/19 (58%)
		zf-H2C2_2	280..305	CDD:290200	11/25 (44%)
		C2H2 Zn finger	296..316	CDD:275368	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	6/143 (4%)
		zf-H2C2_2	337..361	CDD:290200	6/29 (21%)
		zf-C2H2	350..372	CDD:278523	10/113 (9%)
		C2H2 Zn finger	352..372	CDD:275368	9/111 (8%)
		zf-H2C2_2	364..389	CDD:290200	7/31 (23%)
		C2H2 Zn finger	380..400	CDD:275368	3/40 (8%)
		C2H2 Zn finger	408..428	CDD:275368	7/41 (17%)
		zf-H2C2_2	420..444	CDD:290200	7/27 (26%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		zf-H2C2_2	449..473	CDD:290200	8/42 (19%)
		C2H2 Zn finger	464..484	CDD:275368	8/19 (42%)
		zf-H2C2_2	477..501	CDD:290200	12/23 (52%)
		C2H2 Zn finger	492..512	CDD:275368	8/20 (40%)
		zf-H2C2_2	504..529	CDD:290200	10/25 (40%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000