DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF599

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001007249.1	Gene:	ZNF599 / 148103	HGNCID:	26408	Length:	588	Species:	Homo sapiens

Alignment Length:	787	Identity:	153/787 - (19%)
Similarity:	225/787 - (28%)	Gaps:	347/787 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 RSDRDNGSLYSGDEFSKDKKNSSLIREG-----------------DIDFTDDENGFDIRCE---- 342
            ||.||:....:.||....|.....:|.|                 |:: .||..|..:..|
Human   111 RSSRDSRLGQARDEEKLIKIQEGNLRPGTNPHKEICPEKLSYKHDDLE-PDDSLGLRVLQERVTP 174

  Fly   343 -----VCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCEN 402
                 .||...|..|.:.|       .:.:.:.|.:|...|..:..|::|:.| |..::.|.|..
Human   175 QDALHECDSQGPGKDPMTD-------ARNNPYTCTECGKGFSKKWALVRHQQI-HAGVKPYECNE 231

  Fly   403 CSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQF 467
            |.|.....:::.||:| .|.|.:.:.|.||||.|.....|.:||.||:..||:.|:.|.||:|..
Human   232 CGKACRYMADVIRHMR-LHTGEKPYKCIECGKAFKRRFHLTEHQRIHTGDKPYECKECGKAFTHR 295

  Fly   468 SNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPH---QH 529
            |:..:|...| |......|.:|.::|...:|..:|.:.  .||...|......:...|..   ||
Human   296 SSFIQHNMTH-TREKPFLCKECGKAFYYSSSFAQHMRI--HTGKKLYECGECGKAFTHRSTFIQH 357

  Fly   530 PLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPP 594
            .:.|                                   |...|||......:|.
Human   358 NVTH-----------------------------------TGEKPFLCKECGKTFC---------- 377

  Fly   595 FLPQNPLHPTNIPMFFSKNPMDLG-CGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKEL 658
               .|.....::.:...:.|.:.| ||        .||..:..|
Human   378 ---LNSSFTQHMRIHTGEKPYECGECG--------KAFTHRSTF--------------------- 410

  Fly   659 VFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAE 723
                                         |:.|...|
Human   411 -----------------------------IRHKRTHT---------------------------- 418

  Fly   724 DDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQ 788
                                |:.|.:...|.|....|       .:|:.|.   |:|
Human   419 --------------------GEKPFECKECGKAFCDS-------SSLIQHM---RIH-------- 445

  Fly   789 PLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAA 853
                          |.:|.::                              .||.|...|
Human   446 --------------TGEKPYE------------------------------CSECGKAFT----- 461

  Fly   854 FAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPP 918
               .||...       .|...|         ||                          ::||
Human   462 ---HHSVFI-------RHNRTH---------SG--------------------------QKPL-- 479

  Fly   919 VKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVR 983
                             .||.|.|.|..|::.|||:|.||||:||.|:.|.:||:..:|..||.|
Human   480 -----------------ECKECAKAFYYSSSFTRHMRIHTGEKPYVCRECGKAFTQPANFVRHNR 527

  Fly   984 NIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE--------GNNFRDSPSSSGIAEREEYFDDI 1040
             ||..|:||.|:.|:::|.....|.:|::.|..|        |..|..|.|          |...
Human   528 -IHTGEKPFECKECEKAFCDNFALTQHMRTHTGEKPFECNECGKTFSHSSS----------FTHH 581

  Fly  1041 RKFMNRV 1047
            ||...||
Human   582 RKIHTRV 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/30 (20%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	6/20 (30%)
		SUF4-like	403..>445	CDD:411020	14/41 (34%)
		C2H2 Zn finger	403..421	CDD:411020	5/17 (29%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	3/86 (3%)
		COG5048	935..>1028	CDD:227381	40/100 (40%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF599	NP_001007249.1	KRAB	9..69	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368	6/20 (30%)
		C2H2 Zn finger	229..249	CDD:275368	6/20 (30%)
		zf-H2C2_2	244..266	CDD:290200	11/22 (50%)
		COG5048	253..>580	CDD:227381	114/625 (18%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..294	CDD:290200	11/24 (46%)
		C2H2 Zn finger	285..305	CDD:275368	7/19 (37%)
		C2H2 Zn finger	313..333	CDD:275368	5/21 (24%)
		zf-H2C2_2	325..350	CDD:290200	5/26 (19%)
		C2H2 Zn finger	341..361	CDD:275368	3/19 (16%)
		C2H2 Zn finger	369..389	CDD:275368	2/32 (6%)
		zf-H2C2_2	381..406	CDD:290200	6/32 (19%)
		C2H2 Zn finger	397..417	CDD:275368	8/77 (10%)
		zf-H2C2_2	412..432	CDD:290200	6/67 (9%)
		C2H2 Zn finger	425..445	CDD:275368	6/29 (21%)
		zf-H2C2_2	437..462	CDD:290200	10/87 (11%)
		C2H2 Zn finger	453..473	CDD:275368	7/34 (21%)
		C2H2 Zn finger	481..501	CDD:275368	10/19 (53%)
		zf-H2C2_2	493..518	CDD:290200	14/24 (58%)
		C2H2 Zn finger	509..529	CDD:275368	8/20 (40%)
		zf-H2C2_2	521..544	CDD:290200	11/23 (48%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		zf-H2C2_2	549..574	CDD:290200	6/24 (25%)
		C2H2 Zn finger	565..585	CDD:275368	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000