DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF420

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001316444.1	Gene:	ZNF420 / 147923	HGNCID:	20649	Length:	704	Species:	Homo sapiens

Alignment Length:	764	Identity:	174/764 - (22%)
Similarity:	268/764 - (35%)	Gaps:	238/764 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:.|.|.:.....|..|  .:.|..:..:.||||...|.....|..|:.: |...:.|:|:.|.
Human   140 KCKECGKAFRRASHLTQH--QSIHTGEKPYECKQCGKAFSRDSQLSLHQRL-HTGEKPYACKECG 201

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|...|.|..|.| .|.|.:.:.|.||||.|..||.|.:||.:|:..||:.|:.|.||:||.|.
Human   202 KAFTQSSQLILHHR-IHTGEKPYKCEECGKAFIRSSQLTRHQKVHTGEKPYECKECGKAFTQNSQ 265

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---------HHQH 525
            |..|:|:| |.....:|.:|.:.|:.|:.|..||:.  .||..||..:...:         .||.
Human   266 LTLHQRLH-TGEKLYECKECRKVFTQLSQLILHKRI--HTGEKPYECKECGKAFICGSQLSQHQK 327

  Fly   526 PHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAV----AAMSTPPNPFLMFRTAPSFFPG 586
            .|....|:                 |..|...:....::    ..:.|...|:.......:|..|
Human   328 IHNGEKPY-----------------ECKECGRAFIRGSLLMQHQRIHTGEKPYKCEECGKAFIRG 375

  Fly   587 FPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYD 651
            ..       |.|:....||...:..|.     ||             |:   |..|        .
Human   376 SQ-------LTQHQRIHTNEKPYECKE-----CG-------------KM---FSHG--------S 404

  Fly   652 KVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVST 716
            ::|:.:.:...|:..:.:...:||      :|.||       .||:              :|:.|
Human   405 QLTQHQRIHTGEKPYQCKECGKAF------NRGSL-------LTRH--------------QRIHT 442

  Fly   717 PDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKR-SAGSFFTAPAEDNLMLHRFMPRLH 780
                                       |:.|.:...|.|. |.||        .|..|.   |:|
Human   443 ---------------------------GEKPYECKECGKTFSRGS--------ELTQHE---RIH 469

  Fly   781 EFEAERGQPLKMRKSHSS----AESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTS 841
            ..|    :|.:.::...|    ::.:..|:.|.|..|..........|.|
Human   470 TGE----KPYECKECGKSFIRGSQLTQHQRIHTGEKPYECKECRMAFTQS--------------- 515

  Fly   842 EGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGR---RGIEALL 903
                       :..:.|..|.:|..                     |::|...|:   ||:  ||
Human   516 -----------SHLSQHQRLHTGEK---------------------PYVCNECGKAFARGL--LL 546

  Fly   904 AGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYC 968
            .........::|                   |.||.|||.|.|.:.||:|.|.||||:||.||.|
Human   547 IQHQRIHTGEKP-------------------YQCKECGKAFIRGSQLTQHQRIHTGEKPYECKEC 592

  Fly   969 DRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAER 1033
            .:|||..|.|..|.| ||..|:|:.|..|.::|.|.::|.||.:.|         :...:|..:|
Human   593 GKAFSHGSQLTLHQR-IHTGEKPYECRECRKAFTQSSHLSRHQRIH---------TAFLAGQQDR 647

  Fly  1034 EEYFDDIRKFMNRVYTPNSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNN 1082
            .:.:.. |:|...:: |...:        .|......:.|....|:|.|
Human   648 SDIYMS-RRFTKSIF-PVFFS--------VPTMWTSKLELRYSHGDFEN 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	12/86 (14%)
		COG5048	935..>1028	CDD:227381	40/92 (43%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	14/23 (61%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF420	NP_001316444.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910