DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF534

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	766	Identity:	148/766 - (19%)
Similarity:	230/766 - (30%)	Gaps:	350/766 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 DNGSLYSGD-EFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFK- 365
            |.|.::|.: .|::.::    |..|:..:..:|         |.||:..    :.||  |.|.|
Human   231 DCGEIFSSNSNFAQHQR----IHTGEKPYKYNE---------CGKVFNQ----NSHL--AQHQKI 276

  Fly   366 ---QDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
               |..:..|:|...|.|...|.:|..| |...:.|.|..|.|.|...|:|..|: ..|.|.:.:
Human   277 HTGQKPYNNKECGKVFSHHAYLAQHRKI-HTGEKPYKCSECGKAFSVCSSLTAHL-VIHTGEKPY 339

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.||||.|...|.|..||.:|:..:|:.|..|.|.:::.:.|.||:::| |.....||::|.:.
Human   340 DCKECGKVFRHKSSLTTHQTVHTGERPYKCNECGKGFSRIAFLARHRKVH-TGEKPYKCNECGKV 403

  Fly   493 FSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            |...:.|.:|:|.  .||...|:.....:                   |..||           |
Human   404 FIGNSRLARHRKI--HTGGRRYKCNECGK-------------------AFRTC-----------S 436

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
            ...|            .|:..|      |..||..                        :.||
Human   437 DLTA------------HLLIHT------GEKPYEC------------------------IDCG-- 457

  Fly   623 EITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLD 687
                                               .||:                    .:|||.
Human   458 -----------------------------------KVFR--------------------HKSSLT 467

  Fly   688 IKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSI 752
            ...::..                                                 |:.|...:.
Human   468 YHCRIHT-------------------------------------------------GEKPYKCNE 483

  Fly   753 CRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTP 817
            |     |..|:  ...||..||   ::|                      |.:|.:|
Human   484 C-----GKVFS--QNSNLQRHR---KIH----------------------TGEKLYK-------- 508

  Fly   818 TASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEI 882
                                  .:|.|.|  ....:..|.|..:.:|
Human   509 ----------------------CNECGKV--FRQNSHLAQHRDIHTG------------------ 531

  Fly   883 YRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRS 947
                                          ::|                   |||..|||||.|:
Human   532 ------------------------------EKP-------------------YSCNECGKVFRRN 547

  Fly   948 ANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVK 1012
            ::|.||...||||:||.|..|.:.||.:|:|.|| ||||..|:|..|..|.:.|.:.::|.||.|
Human   548 SHLVRHRNVHTGEKPYSCNECGKVFSRNSHLARH-RNIHTGEKPHSCNECGKVFSRNSHLARHRK 611

  Fly  1013 KHESEGNNFRDSPSS------SGIAEREEYFDDIRKF----MNRVYTPNSL 1053
            .|..| ..::.:..|      |.:|:.......::.:    ..:|::.||:
Human   612 IHTGE-KLYKCNECSKVFSRNSRLAQHRNIHTGVKPYSCNECGKVFSKNSI 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	30/87 (34%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	42/98 (43%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368
		COG5048	211..609	CDD:227381	137/711 (19%)
		C2H2 Zn finger	229..249	CDD:275368	4/21 (19%)
		zf-H2C2_2	241..266	CDD:290200	7/37 (19%)
		C2H2 Zn finger	258..277	CDD:275368	9/33 (27%)
		C2H2 Zn finger	286..305	CDD:275368	7/19 (37%)
		zf-H2C2_2	297..321	CDD:290200	8/24 (33%)
		C2H2 Zn finger	313..333	CDD:275368	7/20 (35%)
		C2H2 Zn finger	341..361	CDD:275368	10/19 (53%)
		zf-H2C2_2	353..378	CDD:290200	8/24 (33%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	382..404	CDD:290200	8/22 (36%)
		C2H2 Zn finger	397..417	CDD:275368	6/21 (29%)
		C2H2 Zn finger	425..445	CDD:275368	6/61 (10%)
		C2H2 Zn finger	453..473	CDD:275368	7/100 (7%)
		zf-H2C2_2	465..490	CDD:290200	7/80 (9%)
		C2H2 Zn finger	481..501	CDD:275368	7/29 (24%)
		zf-H2C2_2	493..518	CDD:290200	11/81 (14%)
		C2H2 Zn finger	509..529	CDD:275368	5/21 (24%)
		zf-H2C2_2	521..546	CDD:290200	12/91 (13%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		zf-H2C2_2	549..574	CDD:290200	12/24 (50%)
		C2H2 Zn finger	565..585	CDD:275368	10/20 (50%)
		zf-H2C2_2	577..602	CDD:290200	12/25 (48%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		zf-H2C2_2	605..630	CDD:290200	7/25 (28%)
		C2H2 Zn finger	621..641	CDD:275368	3/19 (16%)
		C2H2 Zn finger	649..669	CDD:275368	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000