DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Gli1

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_034426.2	Gene:	Gli1 / 14632	MGIID:	95727	Length:	1111	Species:	Mus musculus

Alignment Length:	1278	Identity:	253/1278 - (19%)
Similarity:	358/1278 - (28%)	Gaps:	554/1278 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 PPPPTLPLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREP---VCELDIR--DSGGVYA 156
            ||||....||:.:...|.|:..:       :.|...||. |.|..|   |..::.|  ..||.|.
Mouse    69 PPPPPPRSSVKLTKKRALSISPL-------SDASLDLQT-VIRTSPSSLVAFINSRCTSPGGSYG 125

  Fly   157 KTPLQRGTRYGP---FPMKLSHQ-----PNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQD 213
            .  |..|| ..|   ||.::|||     |...|......|...:..|.|         :.|..:.
Mouse   126 H--LSIGT-MSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHP---------QSRGPRA 178

  Fly   214 DCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVV 278
            .|    .|:|.:                 :|:|...|:.|::
Mouse   179 TC----QLKSEL-----------------DMMVGKCPEDPLE----------------------- 199

  Fly   279 AASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGF--DIRC 341
                      |..||..|....|...|.|...::..:::|            .:.|:.:  |.|.
Mouse   200 ----------GDMSSPNSTGTQDHLLGMLDGREDLEREEK------------PEPESVYETDCRW 242

  Fly   342 EVCDKVYPDLDLLDDHLIGAH-HFKQDEFPCK--QCA--LR-FCHRPLLIKHEAISHNNIRKYSC 400
            :.|.:.:...:.|..|:...| |.::.||.|.  .|:  || |..:.:|:.|.. .|...:.:.|
Mouse   243 DGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMR-RHTGEKPHKC 306

  Fly   401 --ENCSKVFCDPSNLQRHIRAYHVGARCHPCPE--CGKTFGTSSGLKQHQH-IHSSVKPFACEV- 459
              |.|.|.:....||:.|:|: |.|.:.:.|.:  |.|.|..:|...:||: .||:.||:.|::
Mouse   307 TFEGCRKSYSRLENLKTHLRS-HTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLP 370

  Fly   460 -CSKAYTQFSNLCRHKR------MHATCR------------------------------------ 481
             |:|.||..|:|.:|.:      .|.|.|
Mouse   371 GCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVP 435

  Fly   482 ----------MQIKCD--------------------KCNQSFSTLTSLTKHKKFC-DSTGPGPYR 515
                      .|..|.                    ....|...|:||.:..  | .:||....|
Mouse   436 ESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGP--CVSATGLSTLR 498

  Fly   516 ---NQHVNRHHQHPHQHP-------LPHQPHLAATATSTCPAPP----RESSESSSSAAAAAVAA 566
               |..:::.||   ..|       ||...| |....|....||    |.||.|||.::|..|:.
Mouse   499 RLENLRLDQLHQ---LRPIGSRGLKLPSLTH-AGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSR 559

  Fly   567 MSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAF 631
            .|:..:||      |   ||.||......||  .|.|....|..::.....|.|.|    |.:|
Mouse   560 RSSLASPF------P---PGTPPENGASSLP--GLTPAQHYMLRARYASARGSGTP----PTAA- 608

  Fly   632 DQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTR 696
                                                                .|||..|.|
Mouse   609 ----------------------------------------------------HSLDRMGGL---- 617

  Fly   697 NDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPP-------PADTPSGG---------- 744
                                                |.||       |...|:.|
Mouse   618 ------------------------------------SVPPWRSRTEYPGYNPNAGVTRRASDPAR 646

  Fly   745 --DGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQP--------LKMRKSHSSA 799
              |.|....:.|.:|.|...|.|   ::...|.....|.......||        :..|......
Mouse   647 AADHPAPARVQRFKSLGCVHTPP---SVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEP 708

  Fly   800 ESSTSQKSH-------------------KGSSPTPTPTASPGLTP-SPSPPTSAG---------- 834
            |..||...:                   :|::..|.....||..| .|.|||:.|
Mouse   709 EVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSY 773

  Fly   835 --------GELSSTSEGGAVPTMAA--AAFA----------------------ADHSALASGPTL 867
                    ||.  .|..|..|:..|  ||::                      :|.:.||  |.|
Mouse   774 PDPTPENWGEF--PSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLA--PCL 834

  Fly   868 --------PQTHPTF--HPLLLEEIYRSGFPFLCQPGG------RRGI----------------- 899
                    |...|.|  ||.|.:..|....|:...|.|      |.|:
Mouse   835 NAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQL 899

  Fly   900 ---------EALLAGAASAAAPKRPLP--PVKFSAGSVVG---LKTKDRYSCKFCGKVFPRSANL 950
                     |.|..|......|.:.||  ..||..||.|.   .||....:..:.....|.|||
Mouse   900 VCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASAN- 963

  Fly   951 TRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFR---------------------- 993
              |   .:|..|.|.. |...|::..|     |..|....|.|
Mouse   964 --H---KSGSYPAPSP-CHETFTVGVN-----RPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCG 1017

  Fly   994 ---------------------CELCDRSFGQQTNLD-----------RHVKKHESEGNNFRDSPS 1026
                                 |...|......|.||           .....|| :|::.:::||
Mouse  1018 HPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHE-QGDSSKNTPS 1081

  Fly  1027 SSGIAEREEYFDDIRKFMNRVYTPNSLAGN--------EGDTE 1061
            .||                   .||...||        .|:|:
Mouse  1082 PSG-------------------PPNMAVGNMSVLLGSLPGETQ 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	31/134 (23%)
		C2H2 Zn finger	341..363	CDD:275368	4/22 (18%)
		C2H2 Zn finger	371..392	CDD:275368	7/25 (28%)
		SFP1	<391..479	CDD:227516	31/100 (31%)
		C2H2 Zn finger	400..421	CDD:275368	8/22 (36%)
		SUF4-like	403..>445	CDD:411020	13/43 (30%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	7/22 (32%)
		C2H2 Zn finger	457..477	CDD:275368	8/27 (30%)
		C2H2 Zn finger	486..504	CDD:275368	5/37 (14%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	25/146 (17%)
		zf-C2H2	935..957	CDD:395048	5/21 (24%)
		C2H2 Zn finger	937..957	CDD:275368	5/19 (26%)
		zf-H2C2_2	949..973	CDD:404364	6/23 (26%)
		C2H2 Zn finger	965..986	CDD:275368	4/20 (20%)
		C2H2 Zn finger	994..1014	CDD:275368	5/30 (17%)
Gli1	NP_034426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..78		4/8 (50%)
		Interaction with SUFU. /evidence=ECO:0000250\|UniProtKB:P08151	123..127		1/5 (20%)
		COG5236	<196..>438	CDD:227561	59/288 (20%)
		FOXP-CC	240..>268	CDD:292777	6/27 (22%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	286..294		1/7 (14%)
		zf-H2C2_2	290..317	CDD:290200	7/27 (26%)
		C2H2 Zn finger	306..328	CDD:275368	8/22 (36%)
		zf-H2C2_2	320..347	CDD:290200	10/27 (37%)
		C2H2 Zn finger	336..359	CDD:275368	7/22 (32%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	348..353		1/4 (25%)
		C2H2 Zn finger	367..388	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..487		12/108 (11%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P08151	378..384		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..583		21/65 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..649		16/147 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..692		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..891		14/58 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1064..1093		10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000