DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF573

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001166161.1 Gene:ZNF573 / 126231 HGNCID:26420 Length:665 Species:Homo sapiens


Alignment Length:763 Identity:166/763 - (21%)
Similarity:264/763 - (34%) Gaps:236/763 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   311 DEFSKDKKNSSLIREGDIDFTDDENGFDIRCEV-------------------------------- 343
            |...:.|:...::|| :..|||    .|::||:                                
Human    79 DLLERGKEPWMILRE-ETQFTD----LDLQCEIISYIEVPTYETDISSTQLQSIYKREKLYECKK 138

  Fly   344 CDKVYPDLDLLDDHLIGAHHFKQDEFP--CKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKV 406
            |.|.:..    ...||..|.|...|.|  ||:|...|.....|..|:.. |...:.|.|..|.|.
Human   139 CQKKFSS----GYQLILHHRFHVIERPYECKECGKNFRSGYQLTLHQRF-HTGEKPYECTECGKN 198

  Fly   407 FCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLC 471
            |.....|..|.| :|.|.:.:.|.:|||.|..:|.:.||:.||:..||:.|:.|.:|::|..:|.
Human   199 FRSGYQLTVHQR-FHTGEKTYECRQCGKAFIYASHIVQHERIHTGGKPYECQECGRAFSQGGHLR 262

  Fly   472 RHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF--------CDSTGPGPYRNQHVNRHHQHPHQ 528
            .|:|:| |.....||.:|.::||..::|.:|.:|        |:..|.. :|..|....||..|.
Human   263 IHQRVH-TGEKPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKA-FRRGHQLTVHQRVHT 325

  Fly   529 HPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFP 593
            ...|::          |    :|..:..::|:.                                
Human   326 GKKPYE----------C----KECGKGYTTASY-------------------------------- 344

  Fly   594 PFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKEL 658
             ||....:|.                ||    .|....:.|..|          ..|..:|..:.
Human   345 -FLLHQRIHK----------------GG----KPYECKECKKTF----------TLYRNLTRHQN 378

  Fly   659 VFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAE 723
            :...|         :.||.::         .||...|.:.....::....::|        .:.:
Human   379 IHTGE---------KLFECKQ---------CGKTYTTGSKLFQHQKTHTGEKP--------YECK 417

  Fly   724 DDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHE----FEA 784
            :..|:..:............|....:...|:|       |.....||..|:   .:|.    ||.
Human   418 ECGKAFSLYGYLKQHQKIHTGMKHFECKECKK-------TFTLYRNLTRHQ---NIHTGKKLFEC 472

  Fly   785 ERGQPLKMRKSHSSAESSTS-QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPT 848
            :     :..|::|:..:... :|:|.|..|                        ....|.|  .|
Human   473 Q-----ECGKAYSTGSNLIQHRKTHTGEKP------------------------YKCKECG--KT 506

  Fly   849 MAAAAFAADHSALASG------PTLPQTHPTFHPLLL-EEIYRSGFPFLCQPGG---RRGIEALL 903
            .:...:...|..:.:|      ....:|...:..|.| :.|:....||.|:..|   ||  .:.|
Human   507 FSLHGYLNQHQKIHTGMKPYECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFRR--SSHL 569

  Fly   904 AGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYC 968
            ....|..|.|:|                   |.||.|||.|.....||:|.:.|||.:||.||.|
Human   570 TAHQSIHADKKP-------------------YECKECGKAFKMYGYLTQHQKIHTGGKPYECKEC 615

  Fly   969 DRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHES 1016
            .:|||.:|||.:|.| ||..|:|:.|:.|.::|...:.|..|.:.|.|
Human   616 GKAFSRASNLVQHER-IHTGEKPYVCKQCGKTFRYGSALKAHQRIHRS 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 6/53 (11%)
C2H2 Zn finger 371..392 CDD:275368 6/20 (30%)
SFP1 <391..479 CDD:227516 31/87 (36%)
C2H2 Zn finger 400..421 CDD:275368 7/20 (35%)
SUF4-like 403..>445 CDD:411020 14/41 (34%)
C2H2 Zn finger 403..421 CDD:411020 6/17 (35%)
C2H2 Zn finger 429..449 CDD:275368 8/19 (42%)
C2H2 Zn finger 457..477 CDD:275368 7/19 (37%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 9/86 (10%)
COG5048 935..>1028 CDD:227381 37/82 (45%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 12/23 (52%)
C2H2 Zn finger 965..986 CDD:275368 11/20 (55%)
C2H2 Zn finger 994..1014 CDD:275368 5/19 (26%)
ZNF573NP_001166161.1 KRAB 28..89 CDD:214630 2/9 (22%)
KRAB 28..67 CDD:279668
C2H2 Zn finger 136..156 CDD:275368 5/23 (22%)
C2H2 Zn finger 164..184 CDD:275368 6/20 (30%)
C2H2 Zn finger 192..212 CDD:275368 7/20 (35%)
C2H2 Zn finger 220..240 CDD:275368 8/19 (42%)
COG5048 244..628 CDD:227381 108/550 (20%)
C2H2 Zn finger 248..268 CDD:275368 7/19 (37%)
zf-H2C2_2 260..285 CDD:290200 9/25 (36%)
C2H2 Zn finger 276..292 CDD:275368 5/15 (33%)
C2H2 Zn finger 304..324 CDD:275368 6/20 (30%)
C2H2 Zn finger 332..352 CDD:275368 5/56 (9%)
C2H2 Zn finger 360..380 CDD:275368 4/29 (14%)
C2H2 Zn finger 388..408 CDD:275368 3/28 (11%)
zf-H2C2_2 401..424 CDD:290200 2/30 (7%)
C2H2 Zn finger 416..436 CDD:275368 1/19 (5%)
C2H2 Zn finger 444..464 CDD:275368 6/29 (21%)
C2H2 Zn finger 472..492 CDD:275368 3/24 (13%)
zf-H2C2_2 484..508 CDD:290200 7/49 (14%)
C2H2 Zn finger 500..520 CDD:275368 4/21 (19%)
zf-H2C2_2 512..536 CDD:290200 3/23 (13%)
C2H2 Zn finger 528..548 CDD:275368 3/19 (16%)
C2H2 Zn finger 556..576 CDD:275368 6/21 (29%)
C2H2 Zn finger 584..604 CDD:275368 9/19 (47%)
zf-H2C2_2 596..621 CDD:290200 13/24 (54%)
C2H2 Zn finger 612..632 CDD:275368 11/20 (55%)
zf-H2C2_2 624..649 CDD:290200 11/25 (44%)
C2H2 Zn finger 640..660 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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