DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF813

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	656	Identity:	141/656 - (21%)
Similarity:	208/656 - (31%)	Gaps:	261/656 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |.::..|.|.:....|.:..||.||:.| |...::|.|:.|.|||....||..| |..|.|.:.:
Human   209 HMREKSFQCNESGKAFNYSSLLRKHQII-HLGEKQYKCDVCGKVFNRKRNLVCH-RRCHTGEKPY 271

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.||||||..:..|..|:.:|:..||:.||.|.||::..|||.||:|:||. ....||::|.::
Human   272 RCNECGKTFSQTYSLTCHRRLHTGEKPYKCEECDKAFSFKSNLKRHRRIHAG-EKPYKCNECGKT 335

  Fly   493 FSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            ||..:|||.|::.  .||..|::                             |....:..|..||
Human   336 FSQTSSLTCHRRL--HTGEKPFK-----------------------------CNECGKTFSRKSS 369

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
            ...                                     .:.||....|...::      ||
Human   370 LTC-------------------------------------HHRLHTGEKPYKCNE------CG-- 389

  Fly   623 EITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLD 687
                                         |...:||..|...:|..
Human   390 -----------------------------KTFSQELTLKCHRRLHT------------------- 406

  Fly   688 IKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSI 752
                                                                    |:.|...:.
Human   407 --------------------------------------------------------GEKPYKCNE 415

  Fly   753 CRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTP 817
            |     |..|...|  ||..|.   |||..|    :|.|..:...:...:::...||.
Human   416 C-----GKVFNKKA--NLARHH---RLHSGE----KPYKCTECVKTFSRNSALVIHKA------- 459

  Fly   818 TASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEI 882
                         ...|.:....:|.|  .|.:..:....|:|:.:|..
Human   460 -------------IHIGEKRYKCNECG--KTFSRISALVIHTAIHTGEK---------------- 493

  Fly   883 YRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPR 946
                 |:.|...| :|...    ....|...|              |.|.:: |.|..|||||.|
Human   494 -----PYKCNECG-KGFNR----KTHLACHHR--------------LHTGEKPYKCNECGKVFNR 534

  Fly   947 SANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHV 1011
            ..:|..|.|.|||::||.|..|.:.|:..::|.||.| :|..|:|::|..|.:.|.|:.||.||.
Human   535 KTHLAHHHRLHTGDKPYKCNECGKVFNQKAHLARHHR-LHTGEKPYKCNECGKVFNQKANLARHH 598

  Fly  1012 KKHESE 1017
            :.|..|
Human   599 RLHTGE 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	141/656 (21%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	11/19 (58%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	36/83 (43%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	139/652 (21%)
		C2H2 Zn finger	217..237	CDD:275368	7/20 (35%)
		zf-H2C2_2	230..254	CDD:290200	11/24 (46%)
		C2H2 Zn finger	245..265	CDD:275368	9/20 (45%)
		zf-H2C2_2	257..282	CDD:290200	13/25 (52%)
		C2H2 Zn finger	273..293	CDD:275368	9/19 (47%)
		zf-H2C2_2	285..309	CDD:290200	10/23 (43%)
		C2H2 Zn finger	301..321	CDD:275368	11/19 (58%)
		zf-H2C2_2	313..338	CDD:290200	11/25 (44%)
		C2H2 Zn finger	329..349	CDD:275368	8/21 (38%)
		zf-H2C2_2	341..366	CDD:290200	8/55 (15%)
		C2H2 Zn finger	357..377	CDD:275368	4/56 (7%)
		zf-H2C2_2	369..394	CDD:290200	7/98 (7%)
		C2H2 Zn finger	385..405	CDD:275368	6/56 (11%)
		zf-H2C2_2	398..421	CDD:290200	6/102 (6%)
		C2H2 Zn finger	413..433	CDD:275368	8/29 (28%)
		C2H2 Zn finger	441..461	CDD:275368	2/39 (5%)
		C2H2 Zn finger	469..489	CDD:275368	5/21 (24%)
		C2H2 Zn finger	497..517	CDD:275368	5/38 (13%)
		zf-H2C2_2	509..534	CDD:290200	11/38 (29%)
		C2H2 Zn finger	525..545	CDD:275368	10/19 (53%)
		C2H2 Zn finger	553..573	CDD:275368	7/20 (35%)
		zf-H2C2_2	565..590	CDD:290200	10/25 (40%)
		C2H2 Zn finger	581..601	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000