DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	1094	Identity:	211/1094 - (19%)
Similarity:	368/1094 - (33%)	Gaps:	327/1094 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ELLHHPN----HFHQQN-QRQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRAQAEHIL------ 133
            |:..||.    .|:.|: |...|.|....||.|.:..     :.:.|.....||.:.::
Human   164 EICPHPPTDLVAFNLQDPQHDSPAPEASALSQEENPR-----NQLMALMLLTAQPQELVMFEEVS 223

  Fly   134 -----QEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNG 193
                 :||.                  ...|:||...:   .:.|.:..|...|.|:..:.:...
Human   224 VCFTSEEWA------------------CLGPIQRALYW---DVMLENYGNVTSLEWETMTENEEV 267

  Fly   194 WLEPTED------------VSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVV 246
            ..:|:..            :...:.::...:::|..:.....:.|      ||:...:...::.:
Human   268 TSKPSSSQRADSHKGTSKRLQGSVPQVLDFEEECEWQVLASQWGN------ETDERADTVKKVSL 326

  Fly   247 DGRPKS----PVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSL 307
            ..|.|.    |.:..:.:...|..|...:|.:.:::  .:.|.|                    .
Human   327 CERDKKKRTPPEKQGQKWKELGDSLTFGSAISESLI--GTEGKK--------------------F 369

  Fly   308 YSGDEFSKD-KKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPC 371
            |..|...|. .|.|.||....|...:..:    :|:.|.|.:.....|..||  .:|..:..:.|
Human   370 YKCDMCCKHFNKISHLINHRRIHTGEKPH----KCKECGKGFIQRSSLLMHL--RNHSGEKPYKC 428

  Fly   372 KQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTF 436
            .:|...|.....|:.|:.| |...:.|.|:.|.|.|...|.|..|:|. |.|.|.:.|.||||.|
Human   429 NECGKAFSQSAYLLNHQRI-HTGEKPYKCKECGKGFYRHSGLIIHLRR-HSGERPYKCNECGKVF 491

  Fly   437 GTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTK 501
            ..::.|..||.:|...:|:.|..|.||:....:|..|:|:|:. ....|||:|.::|:..|.|..
Human   492 SQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSG-EKPYKCDECGKTFAQTTYLID 555

  Fly   502 HKKFCDSTGPGPYRNQHVNR---------HHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            |::.  .:...||:.:...:         .||..|                         :|..:
Human   556 HQRL--HSAENPYKCKECGKVFIRSKSLLLHQRVH-------------------------TEKKT 593

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
            ..........|:..|                      |:....:|....|...::      | |.
Human   594 FGCKKCGKIFSSKSN----------------------FIDHKRMHSREKPYKCTE------C-GK 629

  Fly   623 EITSPVSAFD-QKLPFGFLKGENSE-SQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEED--ESR 683
            ..|.....|| |:|..|....|.:| .:.:  :.:|.|:           |.|.|...|:  |.:
Human   630 AFTQSAYLFDHQRLHNGEKPYECNECGKVF--ILKKSLI-----------LHQRFHTGENLYECK 681

  Fly   684 SSLDIKGKLEDTRNDSKSEEQDDMKQEP-------------------ERVSTPDQ-QQAEDDRKS 728
            ..    ||:..:..:....|:....::|                   :::.|.:: .:.||..|:
Human   682 DC----GKVFGSNRNLIDHERLHNGEKPYECRECGKTFIMSKSFMVHQKLHTQEKAYKCEDCGKA 742

  Fly   729 IDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEA-----ERGQ 788
            ....|:.........|:.|.:.|.|     |..|:  :..||:.|:   |:|..|.     |.|:
Human   743 FSYNSSLLVHRRIHTGEKPFECSEC-----GRAFS--SNRNLIEHK---RIHSGEKPYECDECGK 797

  Fly   789 PLKMRKS-------HSSAES----------------STSQKSHKGSSPTPTPTASPGLTPSPSPP 830
            ...::||       |:..:|                ...|:.|.|..|........|.|.:.:
Human   798 CFILKKSLIGHQRIHTREKSYKCNDCGKVFSYRSNLIAHQRIHTGEKPYACSECGKGFTYNRN-- 860

  Fly   831 TSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGG 895
                                    ..:|..:.||....:.|                  :|:
Human   861 ------------------------LIEHQRIHSGEKTYECH------------------VCR--- 880

  Fly   896 RRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPRSANLTRHLRTHTG 959
                 .:|..:.:....:|              :.|.:: |.|..|||.|.::.||..|.|.|||
Human   881 -----KVLTSSRNLMVHQR--------------IHTGEKPYKCNECGKDFSQNKNLVVHQRMHTG 926

  Fly   960 EQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDS 1024
            |:||.|..|.::|:...||..|.| ||..|:|:.|..|.:.|.|:.||..|.|.|..|      .
Human   927 EKPYECDKCRKSFTSKRNLVGHQR-IHTGEKPYGCNDCSKVFRQRKNLTVHQKIHTDE------K 984

  Fly  1025 PSSSGIAEREEYFDDIRKFMNRVYTPNSLAGNEGDTEEY---PNSDDQSVNLEK 1075
            |....::|:|...........:::|          .||:   .|:::..:.::|
Human   985 PCECDVSEKEFSQTSNLHLQQKIHT----------IEEFSWLQNTNESKIEIQK 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	16/148 (11%)
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	32/87 (37%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	16/109 (15%)
		COG5048	935..>1028	CDD:227381	38/92 (41%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708
		KRAB	216..256	CDD:307490	7/60 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290		1/27 (4%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		zf-H2C2_2	384..409	CDD:316026	6/28 (21%)
		C2H2 Zn finger	400..420	CDD:275368	6/21 (29%)
		COG5048	424..853	CDD:227381	105/514 (20%)
		C2H2 Zn finger	428..448	CDD:275368	6/20 (30%)
		C2H2 Zn finger	456..476	CDD:275368	8/20 (40%)
		C2H2 Zn finger	484..504	CDD:275368	9/19 (47%)
		C2H2 Zn finger	512..532	CDD:275368	7/19 (37%)
		C2H2 Zn finger	540..560	CDD:275368	7/21 (33%)
		C2H2 Zn finger	568..588	CDD:275368	2/19 (11%)
		C2H2 Zn finger	596..616	CDD:275368	3/41 (7%)
		C2H2 Zn finger	624..644	CDD:275368	6/26 (23%)
		C2H2 Zn finger	652..672	CDD:275368	5/32 (16%)
		C2H2 Zn finger	680..700	CDD:275368	3/23 (13%)
		C2H2 Zn finger	708..728	CDD:275368	0/19 (0%)
		C2H2 Zn finger	736..756	CDD:275368	4/19 (21%)
		COG5048	760..>1026	CDD:227381	75/358 (21%)
		C2H2 Zn finger	764..784	CDD:275368	8/29 (28%)
		C2H2 Zn finger	792..812	CDD:275368	4/19 (21%)
		C2H2 Zn finger	820..840	CDD:275368	1/19 (5%)
		C2H2 Zn finger	848..868	CDD:275368	3/45 (7%)
		C2H2 Zn finger	876..896	CDD:275368	4/59 (7%)
		C2H2 Zn finger	904..924	CDD:275368	9/19 (47%)
		C2H2 Zn finger	932..952	CDD:275368	7/20 (35%)
		C2H2 Zn finger	960..980	CDD:275368	8/19 (42%)
		C2H2 Zn finger	988..1008	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910