DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF268

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001159353.1	Gene:	ZNF268 / 10795	HGNCID:	13061	Length:	947	Species:	Homo sapiens

Alignment Length:	934	Identity:	197/934 - (21%)
Similarity:	303/934 - (32%)	Gaps:	307/934 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 HQPNDPQLAWKA--HSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRY 237
            :.||..|:..|:  ||:|        |.....:|...|:                     |:.:.
Human   222 NNPNGFQVHGKSFFHSKH--------EQTVIGIKYCESI---------------------ESGKT 257

  Fly   238 VNAGSEMVVDGRPKSPVQLNEDFMN----GGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDD 298
            ||          .||.:...:.:|.    |......|.::.:.::....:.|:....|.:....|
Human   258 VN----------KKSQLMCQQMYMGEKPFGCSCCEKAFSSKSYLLVHQQTHAEEKPYGCNECGKD 312

  Fly   299 RSDRD----NGSLYSGD---EFSKDKK----NSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLD 352
            .|.:.    :..:::|:   |.|:.:|    :|.|:....|.  ..||.::. || |.||:...|
Human   313 FSSKSYLIVHQRIHTGEKLHECSECRKTFSFHSQLVIHQRIH--TGENPYEC-CE-CGKVFSRKD 373

  Fly   353 LLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHI 417
            .|..|  ...|..|..:.|.:|...|..:..||.||.| |...:.|.|..|.|.|...|||..|.
Human   374 QLVSH--QKTHSGQKPYVCNECGKAFGLKSQLIIHERI-HTGEKPYECNECQKAFNTKSNLMVHQ 435

  Fly   418 RAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRM 482
            |. |.|.:.:.|.:|||.|...|.|..||.||:.|||:.|..|.|.::..|.|..|:|.|...:.
Human   436 RT-HTGEKPYVCSDCGKAFTFKSQLIVHQGIHTGVKPYGCIQCGKGFSLKSQLIVHQRSHTGMKP 499

  Fly   483 QI---------------------------KCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVN 520
            .:                           :|:.|.::||..:.|..|::.  .||..||......
Human   500 YVCNECGKAFRSKSYLIIHTRTHTGEKLHECNNCGKAFSFKSQLIIHQRI--HTGENPYECHECG 562

  Fly   521 R---------HHQHPHQHPLPHQ-----------PHLAATATSTCPAPPRESSESSSSAAAAAVA 565
            :         .||..|....|::           ..|.....:.....|.|.||...
Human   563 KAFSRKYQLISHQRTHAGEKPYECTDCGKAFGLKSQLIIHQRTHTGEKPFECSECQK-------- 619

  Fly   566 AMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSA 630
            |.:|..|..:..||    ..|..||                    |.|.    ||        .|
Human   620 AFNTKSNLIVHQRT----HTGEKPY--------------------SCNE----CG--------KA 648

  Fly   631 FDQKLPFGFLKGENSESQAYD-----KV--TEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDI 688
            |..|......||.::..:.|.     |.  .:.:|:.........:|...:..|:...|:|.|.|
Human   649 FTFKSQLIVHKGVHTGVKPYGCSQCAKTFSLKSQLIVHQRSHTGVKPYGCSECGKAFRSKSYLII 713

  Fly   689 K------GKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGP 747
            .      .|..:.|...||...:......:|:.|                           |:.|
Human   714 HMRTHTGEKPHECRECGKSFSFNSQLIVHQRIHT---------------------------GENP 751

  Fly   748 LDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSS 812
            .:.|.|     |..|.  .:|.|:.|                               |::|.|..
Human   752 YECSEC-----GKAFN--RKDQLISH-------------------------------QRTHAGEK 778

  Fly   813 PTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHP- 876
            |                        ...||.|  ...::.::...|.         :||....|
Human   779 P------------------------YGCSECG--KAFSSKSYLIIHM---------RTHSGEKPY 808

  Fly   877 --------------LLLEEIYRSGF-PFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSV 926
                          |::.|...:|. |:.|..     .|...:|.......:|
Human   809 ECNECGKAFIWKSLLIVHERTHAGVNPYKCSQ-----CEKSFSGKLRLLVHQR------------ 856

  Fly   927 VGLKTKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKER 990
              :.|::: |.|..|||.|.|::.|..|.|||:||:||.|..|.:.||..|.|..|.|. |..|:
Human   857 --MHTREKPYECSECGKAFIRNSQLIVHQRTHSGEKPYGCNECGKTFSQKSILSAHQRT-HTGEK 918

  Fly   991 PFRCELCDRSFGQQTNLDRHVKKH 1014
            |.:|..|.::|..::.|..|.:.|
Human   919 PCKCTECGKAFCWKSQLIMHQRTH 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	14/79 (18%)
		C2H2 Zn finger	341..363	CDD:275368	8/21 (38%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	17/99 (17%)
		COG5048	935..>1028	CDD:227381	33/80 (41%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF268	NP_001159353.1	KRAB	81..141	CDD:214630
		KRAB	81..120	CDD:279668
		C2H2 Zn finger	278..298	CDD:275368	1/19 (5%)
		C2H2 Zn finger	306..326	CDD:275368	2/19 (11%)
		C2H2 Zn finger	334..354	CDD:275368	4/19 (21%)
		zf-H2C2_2	347..371	CDD:290200	9/27 (33%)
		C2H2 Zn finger	362..382	CDD:275368	8/23 (35%)
		zf-H2C2_2	375..397	CDD:290200	6/23 (26%)
		C2H2 Zn finger	390..410	CDD:275368	8/20 (40%)
		zf-H2C2_2	403..427	CDD:290200	11/24 (46%)
		C2H2 Zn finger	418..438	CDD:275368	9/20 (45%)
		zf-H2C2_2	430..454	CDD:290200	10/24 (42%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		COG5048	497..910	CDD:227381	102/577 (18%)
		C2H2 Zn finger	502..522	CDD:275368	0/19 (0%)
		C2H2 Zn finger	530..550	CDD:275368	6/21 (29%)
		zf-H2C2_2	543..567	CDD:290200	6/25 (24%)
		zf-C2H2	556..578	CDD:278523	3/21 (14%)
		C2H2 Zn finger	558..578	CDD:275368	2/19 (11%)
		C2H2 Zn finger	586..606	CDD:275368	1/19 (5%)
		zf-H2C2_2	599..623	CDD:290200	6/31 (19%)
		C2H2 Zn finger	614..634	CDD:275368	7/31 (23%)
		zf-H2C2_2	626..650	CDD:290200	11/59 (19%)
		C2H2 Zn finger	642..662	CDD:275368	8/31 (26%)
		C2H2 Zn finger	670..690	CDD:275368	2/19 (11%)
		C2H2 Zn finger	698..718	CDD:275368	5/19 (26%)
		zf-H2C2_2	710..734	CDD:290200	6/23 (26%)
		C2H2 Zn finger	726..746	CDD:275368	4/19 (21%)
		zf-H2C2_2	739..763	CDD:290200	8/57 (14%)
		C2H2 Zn finger	754..774	CDD:275368	8/57 (14%)
		C2H2 Zn finger	782..802	CDD:275368	4/30 (13%)
		zf-H2C2_2	794..817	CDD:290200	4/31 (13%)
		C2H2 Zn finger	810..830	CDD:275368	2/19 (11%)
		C2H2 Zn finger	838..858	CDD:275368	4/38 (11%)
		zf-H2C2_2	851..875	CDD:290200	8/37 (22%)
		C2H2 Zn finger	866..886	CDD:275368	9/19 (47%)
		C2H2 Zn finger	894..914	CDD:275368	8/20 (40%)
		zf-H2C2_2	907..929	CDD:290200	8/22 (36%)
		C2H2 Zn finger	922..942	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000