DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF273

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_066971.2 Gene:ZNF273 / 10793 HGNCID:13067 Length:569 Species:Homo sapiens


Alignment Length:681 Identity:135/681 - (19%)
Similarity:203/681 - (29%) Gaps:323/681 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:.|.|....|..|..|...|  .:.:.:.||.|...|.....|.||:.| |..:..|.||.|.
Human   207 KCKECGKSCCILSQLTQHKKTA--TRVNFYKCKTCGKAFNQFSNLTKHKII-HPEVNPYKCEECG 268

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|.....|.:| :..|...:.:.|.:|||.|...|.|.:|:.||:..||:.||.|.|.::.||.
Human   269 KAFNQSLTLTKH-KKIHTEEKPYKCEDCGKVFSVFSVLTKHKIIHTGTKPYNCEECGKGFSIFST 332

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQ 534
            |.:||.:| |.....||::|.::|:..::|||||:.  .||..||:.:.                
Human   333 LTKHKIIH-TGEKPYKCNECGKAFNWSSTLTKHKRI--HTGEKPYKCEE---------------- 378

  Fly   535 PHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQN 599
                                                                             
Human   379 ----------------------------------------------------------------- 378

  Fly   600 PLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEE 664
                               ||        .||:|.                ..:|..::|...|:
Human   379 -------------------CG--------KAFNQS----------------STLTRHKIVHTGEK 400

  Fly   665 KLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ-QQAEDDRKS 728
            ..|.|...:||:      ||:...|.|                     |:.|.:: .:.|:..|:
Human   401 PYKCEECGKAFK------RSTTLTKHK---------------------RIYTKEKPYKCEECGKA 438

  Fly   729 IDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMR 793
            ..:.||                                   |..|:.:                 
Human   439 FSVFST-----------------------------------LTKHKII----------------- 451

  Fly   794 KSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFA--A 856
                          |.|:.|                        ....|.|:    |..||:  .
Human   452 --------------HTGAKP------------------------YKCEECGS----AFRAFSTLT 474

  Fly   857 DHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKF 921
            :|..:.:|                                                ::|      
Human   475 EHKRVHTG------------------------------------------------EKP------ 485

  Fly   922 SAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIH 986
                         |.|..|||.|..|:.||:|.|.||||:||.|:.|.:||:.||||.|| :.||
Human   486 -------------YKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRH-KKIH 536

  Fly   987 NKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ..|:|::.:.||.:|....|..||.:.|..|
Human   537 TGEKPYKPKRCDSAFDNTPNFSRHKRNHMGE 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 7/21 (33%)
C2H2 Zn finger 371..392 CDD:275368 8/20 (40%)
SFP1 <391..479 CDD:227516 32/87 (37%)
C2H2 Zn finger 400..421 CDD:275368 7/20 (35%)
SUF4-like 403..>445 CDD:411020 13/41 (32%)
C2H2 Zn finger 403..421 CDD:411020 5/17 (29%)
C2H2 Zn finger 429..449 CDD:275368 8/19 (42%)
C2H2 Zn finger 457..477 CDD:275368 9/19 (47%)
C2H2 Zn finger 486..504 CDD:275368 7/17 (41%)
PTZ00121 <641..>728 CDD:173412 14/87 (16%)
COG5048 935..>1028 CDD:227381 39/83 (47%)
zf-C2H2 935..957 CDD:395048 11/21 (52%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 13/23 (57%)
C2H2 Zn finger 965..986 CDD:275368 10/20 (50%)
C2H2 Zn finger 994..1014 CDD:275368 6/19 (32%)
ZNF273NP_066971.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..31
KRAB 37..97 CDD:214630
KRAB 37..76 CDD:279668
COG5048 191..537 CDD:227381 124/649 (19%)
C2H2 Zn finger 208..228 CDD:275368 6/19 (32%)
C2H2 Zn finger 236..256 CDD:275368 8/20 (40%)
C2H2 Zn finger 264..284 CDD:275368 7/20 (35%)
zf-H2C2_2 277..300 CDD:290200 7/23 (30%)
C2H2 Zn finger 292..312 CDD:275368 8/19 (42%)
C2H2 Zn finger 320..340 CDD:275368 9/19 (47%)
zf-H2C2_2 333..356 CDD:290200 8/23 (35%)
C2H2 Zn finger 348..368 CDD:275368 8/21 (38%)
zf-H2C2_2 361..385 CDD:290200 13/133 (10%)
C2H2 Zn finger 376..396 CDD:275368 6/143 (4%)
zf-H2C2_2 389..413 CDD:290200 7/29 (24%)
C2H2 Zn finger 404..423 CDD:275368 7/45 (16%)
zf-H2C2_2 417..440 CDD:290200 6/43 (14%)
C2H2 Zn finger 432..452 CDD:275368 6/85 (7%)
C2H2 Zn finger 460..480 CDD:275368 6/23 (26%)
zf-H2C2_2 473..496 CDD:290200 8/89 (9%)
C2H2 Zn finger 488..508 CDD:275368 10/19 (53%)
zf-H2C2_2 501..525 CDD:290200 14/23 (61%)
C2H2 Zn finger 516..536 CDD:275368 10/20 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..569 11/32 (34%)
C2H2 Zn finger 544..564 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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