DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Prdm16

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_038967290.1	Gene:	Prdm16 / 100366024	RGDID:	2324431	Length:	1276	Species:	Rattus norvegicus

Alignment Length:	1234	Identity:	361/1234 - (29%)
Similarity:	499/1234 - (40%)	Gaps:	369/1234 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 NQRQQPPPPTLPLSVESSSAAAASVDGM--------------DAFFKDRAQAEHILQEWVRRREP 142
            |...:|.|..|    .|.||...:.||:              ...|..:..:.:....::....|
  Rat    19 NNMYEPDPDLL----ASQSAEEETEDGILSPIPMGPPSPFPTSEDFTPKEGSPYEAPVYIPEDIP 79

  Fly   143 V-CELDIRDSG------GVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNGW--LEPT 198
            : .:.::|:|.      |::||..::.|.|:||:.:.       |:.|.|...   .||  |..|
  Rat    80 IPPDFELRESSIPGAGLGIWAKRKMEIGERFGPYMVA-------PRAALKEAD---FGWEMLTDT 134

  Fly   199 E----------------------------DVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETN 235
            |                            ...:|||.|| |...|..:......||. .::|:..
  Rat   135 EVSSQESCIKKQISEGLGSEKFCVDANQAGAGSWLKYIR-VACSCDDQNLAMCQINE-QIYYKVI 197

  Fly   236 RYVNAGSEMVVDGR-------------PKSPV----------QLNEDFMNGGKVLAAAAAAAAAV 277
            :.:..|.|::|..:             .:.|.          |...|.....|
  Rat   198 KDIEPGEELLVHVKEGAYSLGVMAPSLDEDPTFRCDECDELFQCRLDLRRHKK------------ 250

  Fly   278 VAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCE 342
            .|.|||||                    .||.|  ..::.|...|....|        |....|:
  Rat   251 YACSSSGA--------------------PLYEG--LGEELKPEGLGGGND--------GQAHECK 285

  Fly   343 VCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVF 407
            .|::::|:...|:.|:|  .|.::.|:.|.||...|..:..||:|: :||::.:::.||||.|||
  Rat   286 DCERMFPNKYSLEQHMI--VHTEEREYKCDQCPKAFNWKSNLIRHQ-MSHDSGKRFECENCVKVF 347

  Fly   408 CDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCR 472
            .||||||||||:.|||||.|.||:|||||.||||||||:||||:||||.||||.|:|||||||||
  Rat   348 TDPSNLQRHIRSQHVGARAHACPDCGKTFATSSGLKQHKHIHSTVKPFICEVCHKSYTQFSNLCR 412

  Fly   473 HKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFC------------------------DSTGPGP 513
            ||||||.||.||||..|.|.|||.:||.||::||                        |.|.|.|
  Rat   413 HKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYTPGGLFTPGLPLTPSPMMDKTKPSP 477

  Fly   514 YRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFR 578
            ..|     |.........|.:||..:...|.  |||                          .|.
  Rat   478 TLN-----HGGLGFSEYFPSRPHPGSLPFSA--APP--------------------------AFP 509

  Fly   579 TAPSFFPG-FPP--YGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFL 640
            |....||| |||  |..||.||..||         .|:|::.| ...::.||:.  :..||  .:
  Rat   510 TLTPGFPGIFPPSLYPRPPLLPPTPL---------LKSPLNHG-QDAKLHSPLG--NPALP--LV 560

  Fly   641 KGENSESQAYDKVTEKELVFKAE------EKLK-KEP-LVQAFEGEEDESRSSLDIKGKLEDTRN 697
            ...::.||.....|..|..|...      ||:| :.| :....:.|:..:.:..|:     ||..
  Rat   561 SAVSNSSQGATAATGPEEKFDGRLEDSYVEKVKNRSPDMSDGSDFEDINTTTGTDL-----DTTT 620

  Fly   698 DSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPAD----------------------- 739
            .:.|:...|:  :.:|..:.|:.:..:.:......|.||.|.
  Rat   621 GTGSDLDSDL--DSDRDKSKDKGKPAESKPEFGGASVPPGAMNSVAEVPAFYSQHSFFPPPEEQL 683

  Fly   740 -TPSG--GDGPLDLSICRKRSAGSFFTAPAEDNL------------MLHRFMPRLHEF------- 782
             |.||  ||....::...::..|..|.:..|..|            .|..|...|:.|
  Rat   684 LTASGAAGDSIKAIASIAEKYFGPGFMSMQEKKLGSLPYHSVFPFQFLPNFPHSLYPFTDRALAH 748

  Fly   783 ----EAERGQPL-KMRKSHSSAES----STSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELS 838
                :||...|. .::....|||.    :|..|..|.:..||.....|..........|.|....
  Rat   749 NLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKEAKPALLTPKAPLVPSSGEEQPLDLSIGSRAR 813

  Fly   839 STSEGGAVPTMAAAAFAADHSALASG------PTLPQTHPTFH----------PL---------- 877
            ::..||:........:......:..|      ..||| .|:.|          |:
  Rat   814 ASQNGGSREPRKNHIYGERKPGVGEGLPKVCPAQLPQ-QPSLHYAKPSPFFMDPIYSRVEKRKVA 877

  Fly   878 ----LLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPK-------RPLP--PVKF-----SAG 924
                :|:|.|....|.|..| ....||.:.....|.||.|       :|||  |..|     :..
  Rat   878 DPVGVLKEKYLRPSPLLFHP-QMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNFRSPPPTLS 941

  Fly   925 SVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKE 989
            ..:..|.|:||:|::|||:||||||||||||||||||||.||||||:||||||||||||||||||
  Rat   942 DPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKE 1006

  Fly   990 RPFRCELCDRSFGQQTNLDRHVKKHESEG--------------NNFRDSPSSSG-----IAEREE 1035
            :||:|.||:|.||||||||||:||||.||              .....||:|..     :.|:|:
  Rat  1007 KPFKCHLCNRCFGQQTNLDRHLKKHEHEGAPVSQHSGVLTNHLGTSASSPTSESDNHALLDEKED 1071

  Fly  1036 -YFDDIRKF-----MNRVYT-----------------PNSLAGNEGDTEEYPNSDDQSVNLEKD 1076
             ||.:||.|     ||:..|                 |.|.:..:.|.||   .:::.:..|.|
  Rat  1072 SYFSEIRNFIANSEMNQASTRMDKRPEVQDLDGNPPCPGSASAKQEDVEE---EEEEELEEEDD 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	31/171 (18%)
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	67/87 (77%)
		C2H2 Zn finger	400..421	CDD:275368	17/20 (85%)
		SUF4-like	403..>445	CDD:411020	33/41 (80%)
		C2H2 Zn finger	403..421	CDD:411020	14/17 (82%)
		C2H2 Zn finger	429..449	CDD:275368	16/19 (84%)
		C2H2 Zn finger	457..477	CDD:275368	17/19 (89%)
		C2H2 Zn finger	486..504	CDD:275368	10/17 (59%)
		PTZ00121	<641..>728	CDD:173412	17/94 (18%)
		COG5048	935..>1028	CDD:227381	73/106 (69%)
		zf-C2H2	935..957	CDD:395048	17/21 (81%)
		C2H2 Zn finger	937..957	CDD:275368	16/19 (84%)
		zf-H2C2_2	949..973	CDD:404364	21/23 (91%)
		C2H2 Zn finger	965..986	CDD:275368	19/20 (95%)
		C2H2 Zn finger	994..1014	CDD:275368	15/19 (79%)
Prdm16	XP_038967290.1	PR-SET_PRDM16	61..222	CDD:380990	31/172 (18%)
		C2H2 Zn finger	232..252	CDD:275368	3/31 (10%)
		zf-C2H2	282..304	CDD:395048	6/23 (26%)
		C2H2 Zn finger	284..304	CDD:275368	6/21 (29%)
		zf-H2C2_2	296..320	CDD:404364	8/25 (32%)
		zf-C2H2	310..332	CDD:395048	7/22 (32%)
		C2H2 Zn finger	312..332	CDD:275368	7/20 (35%)
		zf-C2H2	338..359	CDD:395048	16/20 (80%)
		C2H2 Zn finger	340..358	CDD:275368	15/17 (88%)
		zf-C2H2	367..389	CDD:395048	17/21 (81%)
		C2H2 Zn finger	369..389	CDD:275368	16/19 (84%)
		zf-C2H2	395..417	CDD:395048	18/21 (86%)
		C2H2 Zn finger	397..417	CDD:275368	17/19 (89%)
		C2H2 Zn finger	426..444	CDD:275368	10/17 (59%)
		zf-C2H2	952..974	CDD:395048	17/21 (81%)
		C2H2 Zn finger	954..974	CDD:275368	16/19 (84%)
		zf-H2C2_2	966..990	CDD:404364	21/23 (91%)
		SUF4-like	982..>1016	CDD:411020	29/33 (88%)
		C2H2 Zn finger	982..1008	CDD:411020	24/25 (96%)
		C2H2 Zn finger	982..1003	CDD:275368	19/20 (95%)
		zf-C2H2	1009..1031	CDD:395048	16/21 (76%)
		C2H2 Zn finger	1011..1031	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1785
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm45508
orthoMCL	1	0.900	-	-		OOG6_105951
Panther	1	1.100	-	-	LDO	PTHR24393
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2993
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970