DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp958

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_038944925.1	Gene:	Zfp958 / 100302405	RGDID:	2311392	Length:	495	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	144/725 - (19%)
Similarity:	227/725 - (31%)	Gaps:	278/725 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 IDFTDDENGFDIRCEVCDK----VYPDLDL------------LDDHLIGAH-------------H 363
            :|||.:|      ..:.|.    :|.|:.|            |:||.|..|             |
  Rat    11 VDFTSEE------WTLLDPSQKGLYKDVMLETYWNLTAIGYSLEDHNIEEHFQSSRRHGRPERSH 69

  Fly   364 FKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHP 428
            .::..:...:|...|.||..|..||. :|...:.|.|..|.|.|...|:|:.|.|. |.|.:.:.
  Rat    70 TEEKPYEDMKCGEAFAHRSSLRAHER-THTGEKPYGCNQCDKAFAYHSSLRIHERT-HTGEKLYK 132

  Fly   429 CPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSF 493
            |.:|||.|...:.|::|:..||..||..|..|.||:...|:|.:|:|.| |......|::|:::|
  Rat   133 CIQCGKAFSDQNTLQRHKRTHSEEKPCKCNQCGKAFAHHSSLRKHERTH-TGEKPYGCNQCDKAF 196

  Fly   494 STLTSLTKHKKFCDSTGPGPYRNQHVNR---HHQHPHQHPLPHQPHLAATATSTCPAPPRESSES 555
            :..:||.:|::  ..||..||.....::   :|....:|...|
  Rat   197 ACHSSLRRHER--THTGEKPYECNQCDKAFAYHSSLQKHERTH---------------------- 237

  Fly   556 SSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCG 620
                                         .|..||                           ||
  Rat   238 -----------------------------TGEKPY---------------------------GC- 245

  Fly   621 GPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSS 685
                                             .:.:..|.....|:|..  :...||
  Rat   246 ---------------------------------NQCDKAFACHSSLRKHE--RTHTGE------- 268

  Fly   686 LDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ-QQAEDDRKSIDIMSTPPPADTPSGGDGPLD 749
                 |..:.....|:.......::.||:.|.:: .:.....|:..:.:|....:....|:.|.:
  Rat   269 -----KPYECNQCGKAFACHSTLRKHERIHTGEKPYECNQCGKAFSMQNTLRVHERTHTGEKPFE 328

  Fly   750 LSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPT 814
            .:.|.|       |......|.:|:   |:|                      |.:|.|:..
  Rat   329 CNQCGK-------TFKLHSQLRIHK---RVH----------------------TGEKPHECD--- 358

  Fly   815 PTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLL 879
                                              .....||.        |:..|.|...|
  Rat   359 ----------------------------------QCGKTFAC--------PSSFQKHKRVH---- 377

  Fly   880 EEIYRSG-FPFLCQPGGRR-GIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGK 942
                 || .|:.|....:. .|.:.|.........::|                   :.|..|||
  Rat   378 -----SGEKPYGCNQCDKAFAIHSRLRKHERTHTGEKP-------------------FKCNQCGK 418

  Fly   943 VFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNL 1007
            .|.:|.:|..|.||||||:||.|..|.:||...|:|:.|.|. |...:|:.|..|.::||..::|
  Rat   419 TFSQSNSLQVHKRTHTGEKPYECNQCGKAFPYDSSLRVHERT-HTGMKPYECNQCGKAFGYHSHL 482

  Fly  1008 DRHVKKHESE 1017
            .||.:.|..|
  Rat   483 QRHERTHSGE 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	9/50 (18%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	32/87 (37%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	10/87 (11%)
		COG5048	935..>1028	CDD:227381	35/83 (42%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
Zfp958	XP_038944925.1	KRAB	4..44	CDD:396083	8/38 (21%)
		C2H2 Zn finger	80..97	CDD:275368	7/17 (41%)
		C2H2 Zn finger	105..125	CDD:275368	8/20 (40%)
		COG5048	129..490	CDD:227381	109/595 (18%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		C2H2 Zn finger	161..181	CDD:275368	8/19 (42%)
		C2H2 Zn finger	189..209	CDD:275368	6/21 (29%)
		C2H2 Zn finger	217..237	CDD:275368	2/19 (11%)
		C2H2 Zn finger	245..265	CDD:275368	4/55 (7%)
		C2H2 Zn finger	273..293	CDD:275368	3/19 (16%)
		C2H2 Zn finger	301..321	CDD:275368	2/19 (11%)
		C2H2 Zn finger	329..349	CDD:275368	6/29 (21%)
		C2H2 Zn finger	357..377	CDD:275368	5/64 (8%)
		C2H2 Zn finger	385..405	CDD:275368	3/19 (16%)
		C2H2 Zn finger	413..433	CDD:275368	9/19 (47%)
		C2H2 Zn finger	441..461	CDD:275368	8/20 (40%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000