DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and Gm14124

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001135882.1 Gene:Gm14124 / 100216455 MGIID:3652002 Length:715 Species:Mus musculus


Alignment Length:719 Identity:166/719 - (23%)
Similarity:252/719 - (35%) Gaps:155/719 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   344 CDKVYPDLDLLDDHLIGAH-------HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCE 401
            |||.:         ...:|       |..:..:.|.||...|..:..|::|:.| |...:.|:|.
Mouse    80 CDKAF---------AFQSHNQRKEKIHNAETPYECNQCGKSFARKSHLLRHKRI-HTGEKPYACN 134

  Fly   402 NCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQ 466
            .|.|.|..||.||.|.|. ..|.:.:.|.:|||.|..|:||:.|:..|:..|...|..|.||:..
Mouse   135 QCGKDFASPSYLQYHKRV-RTGEKPYKCNQCGKAFACSTGLRGHKRTHTEEKLNECNQCDKAFAG 198

  Fly   467 FSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYR-NQ-------HVN-RH 522
            .|.|..|||.| |.....:|::|.::|:..|.|.:||:.  .||..||. ||       |:. .:
Mouse   199 QSGLLYHKRTH-TGEKPFQCNQCGKTFARNTHLLQHKRV--HTGEKPYECNQCEKASVCHIGLLY 260

  Fly   523 HQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSS----AAAAAVAAMSTPPNPFLMFRTAPSF 583
            |:..|....|:                 |.:|...|    :.........|...||...:...||
Mouse   261 HKRTHAGQRPY-----------------ECNECGKSIVYHSCIKQCKRRHTGEKPFECNQCGKSF 308

  Fly   584 FPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQ 648
            ...      ...|....:|.       .:.|......|.:...|.|       ..:.|..::..:
Mouse   309 ARK------SHLLRHKRIHT-------GEKPYKCDQCGKDFARPSS-------LQYHKRVHTGEK 353

  Fly   649 AYD-KVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPE 712
            .|: |...|  .|.....|::..  :|..||            |..:.....||..........:
Mouse   354 PYECKQCGK--AFACSTVLRRHK--RAHTGE------------KPFECYQCGKSFASKSHLLRHK 402

  Fly   713 RVSTPDQ-QQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFM 776
            |:.|.:: .:.:...|.....|..........|:.|.:.:.|.|..|...:       |:.|:  
Mouse   403 RIHTGEKPYKCDQCGKDFVYHSCIKQCKRRHAGEKPFECNQCGKSFASKSY-------LLRHK-- 458

  Fly   777 PRLHEFEAERGQPLKMRKSHSSAESSTSQKSHK----GSSPTPTPTASPGLTPSPS----PPTSA 833
             |:|..|    :..|..:......|:.|.::||    |..|............|..    ..|..
Mouse   459 -RIHTGE----KHYKCDQCGKDFASTYSLQNHKRVHTGEKPYECKQCGKAFACSSKLRSHKRTHT 518

  Fly   834 GGELSSTSEGGAVPTMAAAAFAADHSALASG---------------PTLPQTHPTFHPLLLEEIY 883
            |.:....::.|  .:.|..:....|..:.:|               |:..|.|...|.       
Mouse   519 GEKPFECNQCG--KSFAIKSHLLRHKRIHTGEKPYKCDQCGKDFARPSSLQYHKRVHT------- 574

  Fly   884 RSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSA 948
                       |.:..|....|.|.|.:.:     ::....:..|.|.   |.|..|||.|...:
Mouse   575 -----------GEKPYECKQCGKAFACSRR-----LRIHKRTHTGEKP---YECNQCGKAFSSPS 620

  Fly   949 NLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKK 1013
            ....|.||||||:||.|..|.::|...||.|.|.|. |..|:||.|:.|.:||.|.|.|.:|.:.
Mouse   621 GFLYHKRTHTGERPYECNECGKSFIHRSNFQMHKRT-HTGEKPFECDQCGKSFAQNTYLLQHKRV 684

  Fly  1014 HESE 1017
            |..|
Mouse   685 HTGE 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 4/25 (16%)
C2H2 Zn finger 371..392 CDD:275368 7/20 (35%)
SFP1 <391..479 CDD:227516 34/87 (39%)
C2H2 Zn finger 400..421 CDD:275368 10/20 (50%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 9/17 (53%)
C2H2 Zn finger 429..449 CDD:275368 9/19 (47%)
C2H2 Zn finger 457..477 CDD:275368 9/19 (47%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 14/88 (16%)
COG5048 935..>1028 CDD:227381 37/83 (45%)
zf-C2H2 935..957 CDD:395048 8/21 (38%)
C2H2 Zn finger 937..957 CDD:275368 7/19 (37%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 8/20 (40%)
C2H2 Zn finger 994..1014 CDD:275368 8/19 (42%)
Gm14124NP_001135882.1 KRAB 4..>45 CDD:214630
KRAB 4..43 CDD:279668
C2H2 Zn finger 79..97 CDD:275368 4/25 (16%)
COG5048 87..514 CDD:227381 109/498 (22%)
C2H2 Zn finger 105..125 CDD:275368 7/20 (35%)
zf-H2C2_2 117..142 CDD:290200 9/25 (36%)
C2H2 Zn finger 133..153 CDD:275368 10/20 (50%)
C2H2 Zn finger 161..181 CDD:275368 9/19 (47%)
C2H2 Zn finger 189..209 CDD:275368 9/19 (47%)
zf-H2C2_2 202..226 CDD:290200 9/24 (38%)
C2H2 Zn finger 217..237 CDD:275368 7/21 (33%)
C2H2 Zn finger 245..265 CDD:275368 4/19 (21%)
C2H2 Zn finger 273..293 CDD:275368 2/19 (11%)
C2H2 Zn finger 301..321 CDD:275368 3/25 (12%)
zf-H2C2_2 313..338 CDD:290200 4/31 (13%)
C2H2 Zn finger 329..349 CDD:275368 4/26 (15%)
zf-H2C2_2 341..366 CDD:290200 6/33 (18%)
C2H2 Zn finger 357..377 CDD:275368 4/23 (17%)
zf-H2C2_2 370..394 CDD:290200 7/37 (19%)
C2H2 Zn finger 385..405 CDD:275368 3/19 (16%)
zf-H2C2_2 397..422 CDD:290200 3/24 (13%)
C2H2 Zn finger 413..433 CDD:275368 2/19 (11%)
C2H2 Zn finger 441..461 CDD:275368 6/29 (21%)
zf-H2C2_2 453..478 CDD:290200 6/38 (16%)
C2H2 Zn finger 469..489 CDD:275368 4/19 (21%)
zf-H2C2_2 481..506 CDD:290200 5/24 (21%)
C2H2 Zn finger 497..517 CDD:275368 1/19 (5%)
zf-H2C2_2 510..533 CDD:290200 3/24 (13%)
C2H2 Zn finger 525..545 CDD:275368 3/21 (14%)
zf-H2C2_2 537..562 CDD:290200 2/24 (8%)
C2H2 Zn finger 553..573 CDD:275368 3/19 (16%)
zf-H2C2_2 565..590 CDD:290200 7/42 (17%)
C2H2 Zn finger 581..601 CDD:275368 3/24 (13%)
zf-H2C2_2 594..618 CDD:290200 8/26 (31%)
C2H2 Zn finger 609..629 CDD:275368 7/19 (37%)
C2H2 Zn finger 637..657 CDD:275368 8/20 (40%)
zf-H2C2_2 649..674 CDD:290200 12/25 (48%)
C2H2 Zn finger 665..685 CDD:275368 8/19 (42%)
zf-H2C2_2 677..702 CDD:290200 4/12 (33%)
C2H2 Zn finger 693..713 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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