DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF717

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:XP_011531546.1 Gene:ZNF717 / 100131827 HGNCID:29448 Length:948 Species:Homo sapiens


Alignment Length:775 Identity:164/775 - (21%)
Similarity:254/775 - (32%) Gaps:240/775 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   308 YSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAH--HFKQDEFP 370
            |..:|..|..:..|.:...:...|.|:   ..:|..|.|.:....||..|    |  |..:..:.
Human   373 YGCNECGKTFRRKSFLTLHERTHTGDK---PYKCIECGKTFHCKSLLTLH----HRTHSGEKPYQ 430

  Fly   371 CKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKT 435
            |.:|...|..:..|..|.. :|...:.|:|::|.:.|...|.|..|.|. |.|.:.:.|.||||.
Human   431 CSECGKTFSQKSYLTIHHR-THTGEKPYACDHCEEAFSHKSRLTVHQRT-HTGEKPYECNECGKP 493

  Fly   436 FGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLT 500
            |...|.|:.||..|:..||:.|..|.|.:.:.|.|..|:..| |.....:|::|.::|...:.||
Human   494 FINKSNLRLHQRTHTGEKPYECNECGKTFHRKSFLTIHQWTH-TGEKPYECNECGKTFRCKSFLT 557

  Fly   501 KHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVA 565
            .|::  ...|..||......:.:.|.....:.|:.|..        ..|.|.:|...|....:  
Human   558 VHQR--THAGEKPYACNECGKTYSHKSYLTVHHRTHTG--------EKPYECNECGKSFHCKS-- 610

  Fly   566 AMSTPPNPFLMF--RTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPV 628
                    ||..  ||    ..|..||                           .|...|.|   
Human   611 --------FLTIHQRT----HAGKKPY---------------------------ECNECEKT--- 633

  Fly   629 SAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLK--------KEPLVQAFEGEEDESRSS 685
              |..||..|..|..::..:.|: ..|....|:.:..|.        ::|.|....|:....:|.
Human   634 --FINKLNLGIHKRTHTGERPYE-CNECGKTFRQKSNLSTHQGTHTGEKPYVCNECGKTFHRKSF 695

  Fly   686 LDIKGKLEDTRNDSKSEEQDDMKQEP----------ERVSTPDQQQAEDDRKSIDIMSTPPP--- 737
            |.|..:....:|     ..|.|..|.          .|..||       .:..:::|:...|   
Human   696 LTIHQRTHTGKN-----RMDVMNVEKLFVRNHTLLYIRELTP-------GKSPMNVMNVENPFIR 748

  Fly   738 ------ADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRK-- 794
                  ....:.|..|::::...|....|..|        :|.   |.|..|    :|.:..:  
Human   749 RQIFRSIKVFTRGRNPMNVANVEKPCQKSVLT--------VHH---RTHTGE----KPYECNECG 798

  Fly   795 ---SHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAA 856
               .|.| ..||.|.:|.|..|                                        :..
Human   799 KTFCHKS-NLSTHQGTHSGEKP----------------------------------------YEC 822

  Fly   857 DHSALASGPTLPQTHPTFHP---LLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPP 918
            |           :...||:.   |.:.:...:|                          ::|   
Human   823 D-----------ECRKTFYDKTVLTIHQRTHTG--------------------------EKP--- 847

  Fly   919 VKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVR 983
                            :.||.|.|.|.:.:.|..|.||||||:|:.|..|.:.||..|.|..|.|
Human   848 ----------------FECKECRKTFSQKSKLFVHHRTHTGEKPFRCNECRKTFSQKSGLSIHQR 896

  Fly   984 NIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAEREEYFDDIRKF 1043
            . |..|:|:.|:.|.::|.|:::|.||.:.|..|         .|.:||....|.....|
Human   897 T-HTGEKPYECKECGKTFCQKSHLSRHQQTHIGE---------KSDVAEAGYVFPQNHSF 946

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 7/23 (30%)
C2H2 Zn finger 371..392 CDD:275368 5/20 (25%)
SFP1 <391..479 CDD:227516 31/87 (36%)
C2H2 Zn finger 400..421 CDD:275368 7/20 (35%)
SUF4-like 403..>445 CDD:411020 16/41 (39%)
C2H2 Zn finger 403..421 CDD:411020 6/17 (35%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 6/19 (32%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 18/104 (17%)
COG5048 935..>1028 CDD:227381 34/92 (37%)
zf-C2H2 935..957 CDD:395048 8/21 (38%)
C2H2 Zn finger 937..957 CDD:275368 8/19 (42%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 8/20 (40%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
ZNF717XP_011531546.1 KRAB 56..116 CDD:214630
KRAB 56..95 CDD:279668
C2H2 Zn finger 217..237 CDD:275368
COG5048 343..723 CDD:227381 96/421 (23%)
C2H2 Zn finger 347..367 CDD:275368
C2H2 Zn finger 375..395 CDD:275368 3/19 (16%)
zf-H2C2_2 388..412 CDD:290200 5/26 (19%)
C2H2 Zn finger 403..423 CDD:275368 7/23 (30%)
zf-H2C2_2 416..440 CDD:290200 7/27 (26%)
zf-C2H2 429..451 CDD:278523 5/22 (23%)
C2H2 Zn finger 431..451 CDD:275368 5/20 (25%)
zf-H2C2_2 443..468 CDD:290200 7/25 (28%)
C2H2 Zn finger 459..479 CDD:275368 7/20 (35%)
zf-H2C2_2 472..494 CDD:290200 10/22 (45%)
C2H2 Zn finger 487..507 CDD:275368 10/19 (53%)
zf-H2C2_2 499..524 CDD:290200 9/24 (38%)
C2H2 Zn finger 515..535 CDD:275368 6/19 (32%)
zf-H2C2_2 528..552 CDD:290200 7/24 (29%)
C2H2 Zn finger 543..563 CDD:275368 6/21 (29%)
C2H2 Zn finger 571..591 CDD:275368 2/19 (11%)
zf-H2C2_2 583..608 CDD:290200 6/32 (19%)
COG5048 595..932 CDD:227381 96/517 (19%)
C2H2 Zn finger 599..619 CDD:275368 6/33 (18%)
C2H2 Zn finger 627..647 CDD:275368 8/24 (33%)
zf-H2C2_2 639..664 CDD:290200 5/25 (20%)
C2H2 Zn finger 655..675 CDD:275368 3/19 (16%)
zf-H2C2_2 667..692 CDD:290200 4/24 (17%)
C2H2 Zn finger 683..703 CDD:275368 4/19 (21%)
zf-H2C2_2 779..801 CDD:290200 6/36 (17%)
C2H2 Zn finger 794..814 CDD:275368 5/20 (25%)
C2H2 Zn finger 822..842 CDD:275368 4/30 (13%)
zf-H2C2_2 835..859 CDD:290200 8/68 (12%)
C2H2 Zn finger 850..870 CDD:275368 8/19 (42%)
zf-H2C2_2 863..887 CDD:290200 12/23 (52%)
C2H2 Zn finger 878..898 CDD:275368 8/20 (40%)
zf-H2C2_2 891..913 CDD:290200 8/22 (36%)
zf-C2H2 904..926 CDD:278523 7/21 (33%)
C2H2 Zn finger 906..926 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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