Protein Alignment ham and ZNF737

DIOPT Version :9

• Sequence 1: NP_724130.4
• Gene: ham / 35135
• FlyBaseID: FBgn0045852
• Length: 1108
• Species: Drosophila melanogaster
• Sequence 2: XP_005259754.1
• Gene: ZNF737 / 100129842
• HGNCID: 32468
• Length: 551
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 150/691 - (21%)
• Similarity: 219/691 - (31%)
• Gaps: 286/691 - (41%)

  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIR-KYSCEN---C------------------SK 405
            ||.:|.:| :|.......:..|.::|...|:|:: |..||:   |                  ||
Human    80 HFARDLWP-EQSIKDSFQKVTLRRYENYGHDNLQFKKGCESVDECKVHKRGYNGLNQYLTTTQSK 143

  Fly   406 VF-CDP--------SNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCS 461
            :| ||.        ||..|| :..|.|.:...|.||||.|..||.|..|:.||:..|||.||.|.
Human   144 IFQCDKYVKVIHKFSNSNRH-KIRHTGKKPFKCIECGKAFNQSSTLTTHKKIHTGEKPFKCEECG 207

  Fly   462 KAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHP 526
            ||:...|:|..|||:| |...:.||:.|.::||..:.||.||..  .:|..||:.:.
Human   208 KAFNWSSHLTTHKRIH-TGEKRYKCEDCGKAFSRFSYLTAHKII--HSGEKPYKCEE-------- 261

  Fly   527 HQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYG 591
                                                                             
Human   262 ----------------------------------------------------------------- 261

  Fly   592 FPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEK 656
                                       ||        .||.:.                ..:|..
Human   262 ---------------------------CG--------KAFKRS----------------SNLTTH 275

  Fly   657 ELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGK-LEDTRNDSKSEEQDDMKQEPERVSTPDQQ 720
            :::...|:..|.|...:||:      |||:....| :.......|.||.....:.|..::|
Human   276 KIIHTGEKPYKCEECGKAFK------RSSILTAHKIIHSGEKPYKCEECGKAFKHPSVLTT---- 330

  Fly   721 QAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAE 785
                 .|.|..            |:.|.....|.:  |..:|:     :|..|:.   :|..|
Human   331 -----HKRIHT------------GEKPYKCEECGR--AFKYFS-----SLTTHKI---IHSGE-- 366

  Fly   786 RGQPLKMRKS----HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAV 846
              :|.|..:.    :.|:..:|.::.|.|..|............|.|..|
Human   367 --KPYKCEECGKAFNWSSHLTTHKRIHTGEKPYKCEECGEAFKYSSSLTT--------------- 414

  Fly   847 PTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAA 911
                       |..:.:|..                     ||.|:..|:
Human   415 -----------HKIIHTGQQ---------------------PFKCEECGK--------------- 432

  Fly   912 PKRPLPPVKFSAGSVVGLKTKDR-------YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCD 969
                    .|...|:  |.|..|       |.|:.|||.|..|::||.|.|.||||:||.|:.|.
Human   433 --------AFKCFSI--LTTHKRIHTGEKPYKCEECGKAFNSSSHLTAHKRIHTGEKPYKCERCG 487

  Fly   970 RAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRH 1010
            :||..|..|.||.| ||..|:|::||.|.:.|...:.|..|
Human   488 KAFKRSFILTRHKR-IHTGEKPYKCEECGKGFKCPSTLTTH 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	150/691 (22%)
		C2H2 Zn finger	371..392	CDD:275368	3/20 (15%)
		SFP1	<391..479	CDD:227516	43/118 (36%)
		C2H2 Zn finger	400..421	CDD:275368	12/50 (24%)
		SUF4-like	403..>445	CDD:411020	21/68 (31%)
		C2H2 Zn finger	403..421	CDD:411020	10/44 (23%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	15/87 (17%)
		COG5048	935..>1028	CDD:227381	36/76 (47%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	6/17 (35%)
ZNF737	XP_005259754.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	143..528	CDD:227381	136/627 (22%)
		zf-H2C2_2	159..184	CDD:290200	11/25 (44%)
		C2H2 Zn finger	175..195	CDD:275368	10/19 (53%)
		zf-H2C2_2	188..211	CDD:290200	12/22 (55%)
		C2H2 Zn finger	203..223	CDD:275368	10/19 (53%)
		zf-H2C2_2	215..240	CDD:290200	10/25 (40%)
		C2H2 Zn finger	231..251	CDD:275368	8/21 (38%)
		zf-H2C2_2	243..268	CDD:290200	11/134 (8%)
		C2H2 Zn finger	259..279	CDD:275368	5/143 (3%)
		zf-H2C2_2	271..296	CDD:290200	6/30 (20%)
		C2H2 Zn finger	287..307	CDD:275368	7/25 (28%)
		zf-H2C2_2	300..324	CDD:290200	4/23 (17%)
		C2H2 Zn finger	315..335	CDD:275368	5/28 (18%)
		zf-H2C2_2	328..352	CDD:290200	7/46 (15%)
		C2H2 Zn finger	343..363	CDD:275368	5/29 (17%)
		zf-H2C2_2	355..379	CDD:290200	6/30 (20%)
		C2H2 Zn finger	371..391	CDD:275368	2/19 (11%)
		zf-H2C2_2	383..408	CDD:290200	4/24 (17%)
		C2H2 Zn finger	399..419	CDD:275368	4/45 (9%)
		C2H2 Zn finger	427..447	CDD:275368	7/44 (16%)
		zf-H2C2_2	440..464	CDD:290200	9/23 (39%)
		C2H2 Zn finger	455..475	CDD:275368	10/19 (53%)
		zf-H2C2_2	467..492	CDD:290200	14/24 (58%)
		C2H2 Zn finger	483..503	CDD:275368	9/20 (45%)
		zf-H2C2_2	496..520	CDD:290200	12/24 (50%)
		C2H2 Zn finger	511..529	CDD:275368	6/17 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000