DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Rex2

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001171238.1	Gene:	Rex2 / 100043034	MGIID:	1328322	Length:	685	Species:	Mus musculus

Alignment Length:	746	Identity:	156/746 - (20%)
Similarity:	224/746 - (30%)	Gaps:	296/746 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 DEFSKDKKNSSLIRE---GDID--FTDDENGFDIRCEVCDKVYP--------DLD---LLDDHLI 359
            ||....::|:|.:..   |:.|  ||..:|     .:...::||        :.|   ....||.
Mouse   180 DEVLVSRQNNSEMNTYTCGEFDKCFTQSDN-----LQSQQRIYPGKKSYKYSESDKCFTQTSHLS 239

  Fly   360 GAH--HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHV 422
            ..|  |..:..:.|.:|...|..:..|.||:.| |...:.|.|..|.|.|.|...|::|.| .|.
Mouse   240 IHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRI-HTGEKPYKCSECDKCFTDKCTLRKHQR-IHT 302

  Fly   423 GARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCD 487
            |.:.:.|.||.|.|.....|:.||.||:..||:.|..|.|.:||.|:|..|:|:|:. ....||.
Mouse   303 GEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHRRIHSG-EKPYKCS 366

  Fly   488 KCNQSFSTLTSLTKHKKFCDSTGPGPYR---------NQHVNRHHQHPHQHPLPHQPHLAATATS 543
            :|::.|:...:|.||::.  .||..||:         .:...|.||..|
Mouse   367 ECDKCFTDKCTLRKHQRI--HTGEKPYKCSECDKCFTEKFTLRKHQRIH---------------- 413

  Fly   544 TCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPM 608
                                                     .|..||
Mouse   414 -----------------------------------------TGEKPY------------------ 419

  Fly   609 FFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQ 673
                                                       |..|.:..|
Mouse   420 -------------------------------------------KCNECDKCF------------- 428

  Fly   674 AFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPA 738
                   ..:.||.:..::.......|..|.|....:|..:|...:..:
Mouse   429 -------TDKGSLRVHQRIHTGEKPYKCSECDKCFTKPSHLSIHRRIHS---------------- 470

  Fly   739 DTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESST 803
                 |:.|...|.|.|     .||.|:.  |.:||   |:|..|    :|.|..:.........
Mouse   471 -----GEKPYKCSECDK-----CFTQPSP--LSIHR---RIHSGE----KPYKCSECDKCFTDKG 516

  Fly   804 S----QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASG 864
            |    |:.|.|..|..........| .||
Mouse   517 SLRVHQRIHIGEKPYKCSECDKCFT-QPS------------------------------------ 544

  Fly   865 PTLPQTHPTFHPLLLEEIYRSGFPFLC--------QPGGRRGIEALLAGAASAAAPKRPLPPVKF 921
                  |.:.|.    .|:....|:.|        ..|..|....:.||       ::|
Mouse   545 ------HLSIHC----RIHSGEKPYKCSECDKCFTHKGSLRVHHRIHAG-------EKP------ 586

  Fly   922 SAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIH 986
                         |.|..|.|.|.....|.||.|.||||:||.|..||:.|:..|:|..|.| ||
Mouse   587 -------------YKCSECDKCFTEKNGLRRHQRIHTGEKPYKCSECDKCFTRKSHLSIHQR-IH 637

  Fly   987 NKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ..|:.::|..||:.|.||.:|..|.|.|..|
Mouse   638 TGEKLYKCSECDKCFTQQCHLSIHQKIHSGE 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/34 (18%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	10/86 (12%)
		COG5048	935..>1028	CDD:227381	37/83 (45%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	9/19 (47%)
Rex2	NP_001171238.1	KRAB	27..67	CDD:366587
		C2H2 Zn finger	197..217	CDD:275368	5/24 (21%)
		C2H2 Zn finger	229..245	CDD:275368	4/15 (27%)
		C2H2 Zn finger	253..273	CDD:275368	7/20 (35%)
		COG5048	277..666	CDD:227381	130/639 (20%)
		C2H2 Zn finger	281..301	CDD:275368	8/20 (40%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		C2H2 Zn finger	365..385	CDD:275368	6/21 (29%)
		C2H2 Zn finger	393..413	CDD:275368	3/19 (16%)
		C2H2 Zn finger	421..441	CDD:275368	4/39 (10%)
		C2H2 Zn finger	449..469	CDD:275368	4/19 (21%)
		C2H2 Zn finger	477..497	CDD:275368	10/29 (34%)
		C2H2 Zn finger	505..525	CDD:275368	2/19 (11%)
		C2H2 Zn finger	533..553	CDD:275368	5/66 (8%)
		C2H2 Zn finger	561..581	CDD:275368	3/19 (16%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
		C2H2 Zn finger	617..637	CDD:275368	8/20 (40%)
		C2H2 Zn finger	645..665	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000