DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF160

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	265	Identity:	70/265 - (26%)
Similarity:	105/265 - (39%)	Gaps:	79/265 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 PPQCSIPAVHP---TLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKC-- 248
            ||:|:|..:.|   :..||:...:.|:                 ...||...||.|:.|.|..
Human    93 PPKCTIKDLLPKEKSSTEAVFHTVVLE-----------------RHESPDIEDFSFKEPQKNVHD 140

  Fly   249 -ELTWPPPT------------------EQLQLELPHPNPKLSPVLPH---PQLQDYQTRRK---- 287
             |..|...|                  ::..:|....|.:|. |..|   |:||.:|...|
Human   141 FECQWRDDTGNYKGVLMAQKEGKRDQRDRRDIENKLMNNQLG-VSFHSHLPELQLFQGEGKMYEC 204

  Fly   288 NKARTAATGGNAT------PN------------------LPQRNKDR-----YTCKFCGKVFPRS 323
            |:...:...|::.      |:                  |.||.|..     |.|..|||.|.::
Human   205 NQVEKSTNNGSSVSPLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCNECGKAFTQN 269

  Fly   324 ANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLK 388
            :|||.|.|.|:||:||||..|.::|::.|||..| :.||..|:|:||..|.:.|...:.|..|.:
Human   270 SNLTSHRRIHSGEKPYKCSECGKTFTVRSNLTIH-QVIHTGEKPYKCHECGKVFRHNSYLATHRR 333

  Fly   389 KHESD 393
            .|..:
Human   334 IHTGE 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	30/91 (33%)
		zf-C2H2	311..333	CDD:278523	11/21 (52%)
		C2H2 Zn finger	313..333	CDD:275368	10/19 (53%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	7/20 (35%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	6/21 (29%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	11/21 (52%)
		C2H2 Zn finger	259..279	CDD:275368	10/19 (53%)
		zf-H2C2_2	271..295	CDD:290200	13/23 (57%)
		C2H2 Zn finger	287..307	CDD:275368	7/20 (35%)
		zf-H2C2_2	299..324	CDD:290200	11/25 (44%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		zf-H2C2_2	327..350	CDD:290200	3/12 (25%)
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..519	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
		zf-H2C2_2	551..576	CDD:290200
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		zf-H2C2_2	607..632	CDD:290200
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..659	CDD:290200
		C2H2 Zn finger	651..671	CDD:275368
		zf-H2C2_2	663..688	CDD:290200
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910