DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10348 and ZNF236

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001293018.1	Gene:	ZNF236 / 7776	HGNCID:	13028	Length:	1847	Species:	Homo sapiens

Alignment Length:	450	Identity:	103/450 - (22%)
Similarity:	160/450 - (35%)	Gaps:	114/450 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PRKMLPSPKQGCVYPALGLIPTSYISHVPY-DLASSASVAATSSSSTSPTTTSATTTGRLQHQHS 71
            |..::..|..|     |.|.||...:::.. .|:...||..|:||.|...|...|:.|.:.....
Human  1432 PASVVIQPISG-----LSLQPTVTSANLTIGPLSEQDSVLTTNSSGTQDLTQVMTSQGLVSPSGG 1491

  Fly    72 -HQQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENS----NLIMFASEL----- 126
             |:...|:|:       ||..|.|           ....||....:|    .:.:..|||
Human  1492 PHEITLTINN-------SSLSQVL-----------AQAAGPTATSSSGSPQEITLTISELNTTSG 1538

  Fly   127 ---AVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGG-------------------- 168
               :........::..::..|.:.:|.|.|..:..|..:|...||
Human  1539 SLPSTTPMSPSAISTQNLVMSSSGVGGDASVTLTLADTQGMLSGGLDTVTLNITSQGQQFPALLT 1603

  Fly   169 ----GGGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPA 229
                .|.||.|.             ||..:.:..|....|..:.:..|...|...:.||  |.|.
Human  1604 DPSLSGQGGAGS-------------PQVILVSHTPQSASAACEEIAYQVAGVSGNLAPG--NQPE 1653

  Fly   230 ASSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLPHPQLQDYQTRRKN------ 288
            ....        .|...:|:..:                ..:.||.|...:.:...|.:
Human  1654 KEGR--------AHQCLECDRAF----------------SSAAVLMHHSKEVHGRERIHGCPVCR 1694

  Fly   289 KARTAAT-------GGNATPNLPQRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCER 346
            ||...||       ...|.|:|..:....:.|..|.|.|.:.:.|.||.|.||||:|:.|..||:
Human  1695 KAFKRATHLKEHMQTHQAGPSLSSQKPRVFKCDTCEKAFAKPSQLERHSRIHTGERPFHCTLCEK 1759

  Fly   347 SFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSER 406
            :|:..|.||.|::. |..|||:||..|...|.|::|:..|:|:..|.|.:|...:|..|:
Human  1760 AFNQKSALQVHMKK-HTGERPYKCAYCVMGFTQKSNMKLHMKRAHSYAGALQESAGHPEQ 1818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	23/62 (37%)
		zf-C2H2	311..333	CDD:278523	8/21 (38%)
		C2H2 Zn finger	313..333	CDD:275368	8/19 (42%)
		zf-H2C2_2	325..349	CDD:290200	12/23 (52%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
ZNF236	NP_001293018.1	C2H2 Zn finger	41..61	CDD:275368
		COG5048	<52..234	CDD:227381
		C2H2 Zn finger	70..90	CDD:275368
		C2H2 Zn finger	97..117	CDD:275368
		C2H2 Zn finger	125..145	CDD:275370
		C2H2 Zn finger	157..177	CDD:275368
		COG5048	197..707	CDD:227381
		zf-C2H2	199..221	CDD:278523
		C2H2 Zn finger	201..221	CDD:275368
		zf-H2C2_2	214..238	CDD:290200
		C2H2 Zn finger	229..249	CDD:275368
		zf-H2C2_2	241..266	CDD:290200
		C2H2 Zn finger	257..278	CDD:275368
		C2H2 Zn finger	289..310	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		zf-H2C2_2	498..522	CDD:290200
		C2H2 Zn finger	514..534	CDD:275368
		zf-H2C2_2	527..551	CDD:290200
		C2H2 Zn finger	542..562	CDD:275368
		zf-H2C2_2	554..579	CDD:290200
		C2H2 Zn finger	570..590	CDD:275368
		COG5048	653..1057	CDD:227381
		C2H2 Zn finger	661..681	CDD:275368
		zf-H2C2_2	673..698	CDD:290200
		C2H2 Zn finger	689..709	CDD:275368
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		C2H2 Zn finger	745..765	CDD:275368
		COG5048	953..1315	CDD:227381
		zf-C2H2	969..991	CDD:278523
		C2H2 Zn finger	971..991	CDD:275368
		zf-H2C2_2	983..1008	CDD:290200
		C2H2 Zn finger	999..1019	CDD:275368
		C2H2 Zn finger	1027..1047	CDD:275368
		zf-H2C2_2	1039..1064	CDD:290200
		C2H2 Zn finger	1171..1191	CDD:275368
		zf-H2C2_2	1183..1207	CDD:290200
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		zf-H2C2_2	1239..1264	CDD:290200
		C2H2 Zn finger	1255..1275	CDD:275370
		C2H2 Zn finger	1661..1682	CDD:275368	4/36 (11%)
		C2H2 Zn finger	1690..1710	CDD:275368	4/19 (21%)
		COG5048	1707..>1775	CDD:227381	24/68 (35%)
		C2H2 Zn finger	1726..1746	CDD:275368	8/19 (42%)
		zf-H2C2_2	1739..1763	CDD:290200	13/23 (57%)
		C2H2 Zn finger	1754..1774	CDD:275368	8/20 (40%)
		zf-H2C2_2	1766..1791	CDD:290200	11/25 (44%)
		C2H2 Zn finger	1782..1800	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910