DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF112

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001335210.1	Gene:	ZNF112 / 7771	HGNCID:	12892	Length:	930	Species:	Homo sapiens

Alignment Length:	155	Identity:	46/155 - (29%)
Similarity:	69/155 - (44%)	Gaps:	40/155 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVR---------------- 359
            |.|:.|||.|.:|:.|..|.|.|||.:||||:.|.:.||.||.||.|.|
Human   766 YKCEMCGKGFSQSSRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQRVHVEGRPYKCEQCGKG 830

  Fly   360 -----------NIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSG----------V 403
                       .:|..|:|:|||:|.:.|.|::||..|.:.|..:........|          :
Human   831 FSGYSSLQAHHRVHTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFRWSSGLLI 895

  Fly   404 SERMHCIRRFCENPTEESYFEEIRS 428
            .:|:|...:|.::   |.|.::..|
Human   896 HQRVHSSDKFYKS---EDYGKDYPS 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/78 (33%)
		zf-C2H2	311..333	CDD:278523	10/21 (48%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	11/23 (48%)
		C2H2 Zn finger	341..362	CDD:275368	10/47 (21%)
		zf-H2C2_2	353..377	CDD:290200	11/50 (22%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	8/19 (42%)
ZNF112	NP_001335210.1	KRAB	25..85	CDD:214630
		C2H2 Zn finger	250..269	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	305..321	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368
		COG5048	401..773	CDD:227381	3/6 (50%)
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
		C2H2 Zn finger	520..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		C2H2 Zn finger	656..676	CDD:275368
		C2H2 Zn finger	684..704	CDD:275368
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		SFP1	<780..873	CDD:227516	31/92 (34%)
		C2H2 Zn finger	796..816	CDD:275368	10/19 (53%)
		C2H2 Zn finger	824..844	CDD:275368	0/19 (0%)
		C2H2 Zn finger	852..872	CDD:275368	8/19 (42%)
		zf-H2C2_2	864..888	CDD:316026	5/23 (22%)
		C2H2 Zn finger	880..900	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910