DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF45

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_003416.1	Gene:	ZNF45 / 7596	HGNCID:	13111	Length:	682	Species:	Homo sapiens

Alignment Length:	238	Identity:	63/238 - (26%)
Similarity:	95/238 - (39%)	Gaps:	72/238 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICER 375
            |.|:.|||.|.:::||..|.|.||||:||||..|.:.||.||:|..|.| ||..|:|:|||.|.:
Human   444 YKCEECGKGFSQASNLLAHQRGHTGEKPYKCGTCGKGFSRSSDLNVHCR-IHTGEKPYKCERCGK 507

  Fly   376 CFGQQTNLDRHLKKHESD----------AVSLSALSGVSERMH----------CIRRFCE----- 415
            .|.|.::|..|.:.|..:          ..|:.:.....:|.|          |.:.||.
Human   508 AFSQFSSLQVHQRVHTGEKPYQCAECGKGFSVGSQLQAHQRCHTGEKPYQCEECGKGFCRASNFL 572

  Fly   416 -----NPTEESYFEEI-------RSFM------------------GKVTQQQQQQQQQQQHDQQQ 450
                 :..|:.|..::       ||::                  |||.......|..|:....:
Human   573 AHRGVHTGEKPYRCDVCGKRFRQRSYLQAHQRVHTGERPYKCEECGKVFSWSSYLQAHQRVHTGE 637

  Fly   451 QQHQSTATSASSSCSSS--------------RDTPTS--SHEE 477
            :.::........|.|||              :|.|:|  ||.:
Human   638 KPYKCEECGKGFSWSSSLIIHQRVHADDEGDKDFPSSEDSHRK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/51 (53%)
		zf-C2H2	311..333	CDD:278523	10/21 (48%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	11/23 (48%)
		zf-C2H2	368..390	CDD:278523	8/21 (38%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
ZNF45	NP_003416.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	166..186	CDD:275368
		COG5048	190..602	CDD:227381	49/158 (31%)
		C2H2 Zn finger	194..214	CDD:275368
		C2H2 Zn finger	251..270	CDD:275368
		C2H2 Zn finger	278..298	CDD:275368
		zf-H2C2_2	290..314	CDD:290200
		C2H2 Zn finger	306..326	CDD:275368
		zf-H2C2_2	319..343	CDD:290200
		C2H2 Zn finger	334..354	CDD:275368
		zf-H2C2_2	346..370	CDD:290200
		C2H2 Zn finger	362..382	CDD:275368
		zf-H2C2_2	374..397	CDD:290200
		C2H2 Zn finger	390..410	CDD:275368
		zf-H2C2_2	402..427	CDD:290200
		C2H2 Zn finger	418..438	CDD:275368
		zf-H2C2_2	430..455	CDD:290200	6/10 (60%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		zf-H2C2_2	458..483	CDD:290200	14/24 (58%)
		C2H2 Zn finger	474..494	CDD:275368	9/20 (45%)
		zf-H2C2_2	486..511	CDD:290200	12/25 (48%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		zf-H2C2_2	514..538	CDD:290200	3/23 (13%)
		C2H2 Zn finger	530..550	CDD:275368	2/19 (11%)
		zf-H2C2_2	543..565	CDD:290200	3/21 (14%)
		C2H2 Zn finger	558..578	CDD:275368	3/19 (16%)
		zf-H2C2_2	570..595	CDD:290200	2/24 (8%)
		zf-C2H2	584..606	CDD:278523	3/21 (14%)
		C2H2 Zn finger	586..606	CDD:275368	2/19 (11%)
		zf-H2C2_2	598..622	CDD:290200	3/23 (13%)
		C2H2 Zn finger	614..634	CDD:275368	5/19 (26%)
		zf-H2C2_2	626..650	CDD:290200	2/23 (9%)
		C2H2 Zn finger	642..662	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..682		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910