DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and KLF10

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_005646.1	Gene:	KLF10 / 7071	HGNCID:	11810	Length:	480	Species:	Homo sapiens

Alignment Length:	431	Identity:	105/431 - (24%)
Similarity:	159/431 - (36%)	Gaps:	117/431 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HSPRKMLPSPKQGCVYPALGLIPTSYIS-----HV--PYDLASSASVAATSSSSTSPTTTSATTT 63
            :||....||.....:.||...:....:|     |:  |:.....:.|:|       |....|..|
Human    96 YSPSDFEPSQVSNLMAPAPSTVHFKSLSDTAKPHIAAPFKEEEKSPVSA-------PKLPKAQAT 153

  Fly    64 GRLQHQHSHQ--QHQT--------LNHHAKGKRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSN 118
            ..::|....|  .|||        ||:     :.:||          :|:|.|    .:|....|
Human   154 SVIRHTADAQLCNHQTCPMKAASILNY-----QNNSF----------RRRTHL----NVEAARKN 199

  Fly   119 LIMFASELAVAQQKEKELNNNHIA-------ASLADLGFDMSRKMLRALREGGAGGGGGGGGGGG 176
            :     ..|.......:...|.:|       |:|.|.....|..::  .|...|
Human   200 I-----PCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVI--CRSQPA----------- 246

  Fly   177 GGGGPPNAPP-----LTPPQCSIPAVHPTLLEAMTKNLPLQYRN-VFAGVLPGKVNS-PAASSSP 234
                 |.:|.     ::||..|...|.|  :..:.:.:||...| |...|:|....| |.|...|
Human   247 -----PVSPQQKSVLVSPPAVSAGGVPP--MPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPP 304

  Fly   235 T---GADFP-----FRHPLKKCELTWPPPTEQLQLELPHPN-PKLSPVLPHPQLQDYQTRRKNKA 290
            .   |...|     |..|....:.:.||        :..|| .:|||:.|.|..
Human   305 VVFMGTQVPKGAVMFVVPQPVVQSSKPP--------VVSPNGTRLSPIAPAPGF----------- 350

  Fly   291 RTAATGGNATPNLPQRNKDRYTCKF--CGKVFPRSANLTRHLRTHTGEQPYKC--KYCERSFSIS 351
              :.:....||.:.......:.|..  |||.:.:|::|..|.||||||:|:.|  |.|||.|:.|
Human   351 --SPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARS 413

  Fly   352 SNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHES 392
            ..|.|| |..|..|:.|.|.:|:|.|.:..:|.:|.::|.|
Human   414 DELSRH-RRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	27/66 (41%)
		zf-C2H2	311..333	CDD:278523	8/23 (35%)
		C2H2 Zn finger	313..333	CDD:275368	8/21 (38%)
		zf-H2C2_2	325..349	CDD:290200	14/25 (56%)
		C2H2 Zn finger	341..362	CDD:275368	11/22 (50%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
KLF10	NP_005646.1	zf-C2H2	369..393	CDD:278523	8/23 (35%)
		COG5048	374..>424	CDD:227381	24/50 (48%)
		C2H2 Zn finger	374..393	CDD:275368	7/18 (39%)
		zf-H2C2_2	385..412	CDD:290200	15/26 (58%)
		C2H2 Zn finger	401..423	CDD:275368	11/22 (50%)
		zf-H2C2_2	415..438	CDD:290200	10/23 (43%)
		zf-C2H2	429..451	CDD:278523	7/21 (33%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910