DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and Zxdb

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001074942.1	Gene:	Zxdb / 668166	MGIID:	3694898	Length:	873	Species:	Mus musculus

Alignment Length:	433	Identity:	104/433 - (24%)
Similarity:	142/433 - (32%)	Gaps:	166/433 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GGAGGGGGGGGGGGGGG------------------------------------------------ 179
            ||.||||||||||||||
Mouse   102 GGGGGGGGGGGGGGGGGSRGGSDDFFLLLLDPVGGDVETVGTEQAGAPVRREEAGAGPRPERRQS 166

  Fly   180 -GPPNAPPLTPPQC--SIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGA---- 237
             |||...|...|:|  ::||..|         ||.      ||..|....:.||:::..|.
Mouse   167 AGPPAGRPEPGPRCLSAVPAASP---------LPA------AGPGPAAAAAAAAAAAFAGTITIH 216

  Fly   238 --DFPFRHPLKKCELTWPP-PT-EQLQLELPHPNPKLSP---VLPHPQLQDYQTRRKNKARTAAT 295
              |...|.......||.|| |. |......|.|.|...|   :.|......:.......|..||.
Mouse   217 NQDLLLRFENGVLTLTTPPLPAWEPGVAPFPQPQPPPQPGALIAPQAAAAGFPPAAAAAAAAAAA 281

  Fly   296 GGN--------------------ATPNLPQRNKDR-----------------------YTC--KF 315
            |..                    |.|..|:...:.                       |.|  ..
Mouse   282 GAQLGDCPELPPDLLLAEPAEPAACPAPPEEEAEAPAAAAAQSPRGPAGPGPGPGVVLYLCPEAQ 346

  Fly   316 CGKVFPRSANLTRHLRTHT---GEQPYKCKY--CERSFSISSNLQRHVRNIHNKERPFKCEI--C 373
            ||:.|.:...|..||.||:   |::|:||..  |..:|:.|..|:||::: |:|.|||.|.:  |
Mouse   347 CGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLSGCGWTFTTSYKLKRHLQS-HDKLRPFGCPVQGC 410

  Fly   374 ERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRF-CENPTEESYFEEIRSFMGKVTQQQ 437
            .:.|....||..|:|.||.:                 ..| || ..|||:           ..|.
Mouse   411 GKSFTTVYNLKAHMKGHEQE-----------------NSFKCE-VCEESF-----------PTQA 446

  Fly   438 QQQQQQQQHDQQQQQHQSTATSASSSCSSSRDTPTS--SHEEA 478
            :....|:.|.:.::.:|    .|.|.|..:..|.::  ||..|
Mouse   447 KLSTHQRSHFEPERPYQ----CAFSGCKKTFITVSALFSHNRA 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	22/92 (24%)
		zf-C2H2	311..333	CDD:278523	8/23 (35%)
		C2H2 Zn finger	313..333	CDD:275368	7/21 (33%)
		zf-H2C2_2	325..349	CDD:290200	10/28 (36%)
		C2H2 Zn finger	341..362	CDD:275368	7/22 (32%)
		zf-H2C2_2	353..377	CDD:290200	10/25 (40%)
		zf-C2H2	368..390	CDD:278523	8/23 (35%)
		C2H2 Zn finger	370..390	CDD:275368	7/21 (33%)
Zxdb	NP_001074942.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..120		16/17 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..184		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..330		3/28 (11%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	340..646		51/180 (28%)
		C2H2 Zn finger	342..364	CDD:275368	7/21 (33%)
		zf-C2H2_aberr	373..518	CDD:293622	39/147 (27%)
		C2H2 Zn finger	375..397	CDD:275368	7/22 (32%)
		C2H2 Zn finger	405..427	CDD:275368	7/21 (33%)
		zf-H2C2_2	419..442	CDD:290200	11/40 (28%)
		C2H2 Zn finger	435..455	CDD:275368	7/31 (23%)
		C2H2 Zn finger	464..486	CDD:275368	7/22 (32%)
		C2H2 Zn finger	498..517	CDD:275368
		COG5048	<510..642	CDD:227381
		C2H2 Zn finger	525..547	CDD:275368
		C2H2 Zn finger	555..577	CDD:275368
		C2H2 Zn finger	585..607	CDD:275370
		Required for transcriptional activation. /evidence=ECO:0000250	645..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910