DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and SP1

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_612482.2	Gene:	SP1 / 6667	HGNCID:	11205	Length:	785	Species:	Homo sapiens

Alignment Length:	538	Identity:	118/538 - (21%)
Similarity:	185/538 - (34%)	Gaps:	196/538 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPSPKQGCVYPALGLI------PTSYISHVPYDL------------------ASSASVAATSSSS 52
            :|:..|..| |..||.      .|.|:::||..|                  .||.:|..:||.|
Human   228 MPNLLQQAV-PLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGS 291

  Fly    53 --------TSPTTTS--------ATTTGRLQHQHSHQQHQT------LNHHAKGKRRSSFDQPLD 95
                    ||.||.|        |:::....:.:|:....|      :|....|...::......
Human   292 QESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTP 356

  Fly    96 LRLAHKRKTDLVDQGPMEDENSNLIMFASELAVAQQKEKELNNNH-------------------- 140
            .|::..:.:|.::  ..:::.|     ...|...||||.|.|...
Human   357 QRVSGLQGSDALN--IQQNQTS-----GGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQA 414

  Fly   141 -IAASLADLGFD---MSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQCSIPAVHP-- 199
             .||.|:...|.   :|::.|:.|:....                ||:.|:.   ...|.|.|
Human   415 LQAAPLSGQTFTTQAISQETLQNLQLQAV----------------PNSGPII---IRTPTVGPNG 460

  Fly   200 -----TLL---------EAMTKNL-PLQYRNVFAGVLPGKVNS--------PAASSSPTGADFPF 241
                 ||.         :|.|..| |:|      ||..|:.:|        .:|:|.|.|.
Human   461 QVSWQTLQLQNLQVQNPQAQTITLAPMQ------GVSLGQTSSSNTTLTPIASAASIPAGT---- 515

  Fly   242 RHPLKKCELTWPPPTEQLQLEL-------PHPNPKLSPVLPH----------------------- 276
             ..:...:|:..|..:.:.|..       .||...|...:.:
Human   516 -VTVNAAQLSSMPGLQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDT 579

  Fly   277 ---------PQLQDYQTRRKNKARTAAT---------GGNATPNLPQRNKDRYTCKF--CGKVFP 321
                     |..|....||..  |.|.|         .|:..|.    .|.::.|..  ||||:.
Human   580 AGGEEGENSPDAQPQAGRRTR--REACTCPYCKDSEGRGSGDPG----KKKQHICHIQGCGKVYG 638

  Fly   322 RSANLTRHLRTHTGEQPYKC--KYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLD 384
            ::::|..|||.||||:|:.|  .||.:.|:.|..||||.|. |..|:.|.|..|.:.|.:..:|.
Human   639 KTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRT-HTGEKKFACPECPKRFMRSDHLS 702

  Fly   385 RHLKKHES----DAVSLS 398
            :|:|.|::    ..|:||
Human   703 KHIKTHQNKKGGPGVALS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/66 (39%)
		zf-C2H2	311..333	CDD:278523	9/23 (39%)
		C2H2 Zn finger	313..333	CDD:275368	9/21 (43%)
		zf-H2C2_2	325..349	CDD:290200	12/25 (48%)
		C2H2 Zn finger	341..362	CDD:275368	10/22 (45%)
		zf-H2C2_2	353..377	CDD:290200	10/23 (43%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		Repressor domain	2..82
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..141
		Transactivation domain A (Gln-rich)	146..251		6/23 (26%)
		Transactivation domain B (Gln-rich)	261..495		49/265 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..395		13/72 (18%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	462..470		2/7 (29%)
		Transactivation domain C (highly charged)	496..610		18/120 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..598		2/30 (7%)
		VZV IE62-binding	619..785		39/107 (36%)
		C2H2 Zn finger	628..650	CDD:275368	9/21 (43%)
		zf-H2C2_2	642..669	CDD:290200	13/26 (50%)
		C2H2 Zn finger	658..680	CDD:275368	10/22 (45%)
		zf-H2C2_2	672..695	CDD:290200	10/23 (43%)
		zf-C2H2	686..708	CDD:278523	7/21 (33%)
		C2H2 Zn finger	688..708	CDD:275368	6/19 (32%)
		Domain D	708..785		4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910