DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and PRDM16

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_071397.3	Gene:	PRDM16 / 63976	HGNCID:	14000	Length:	1276	Species:	Homo sapiens

Alignment Length:	697	Identity:	184/697 - (26%)
Similarity:	256/697 - (36%)	Gaps:	260/697 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VYPALGLIP-----TSYISH-----VPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQ 74
            :||...|:|     .|.::|     :|..|.:.|....::.|::|..||:|...
Human   522 LYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGP----------- 575

  Fly    75 HQTLNHHAKGKRRSSFDQPLDLRLAHKRKT---DLVDQGPMEDENSNLIMFASELAVAQQKEKEL 136
                        ...|:..|:.....|.||   |:.|....||.|:..   .::|........:|
Human   576 ------------EEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTT---GTDLDTTTGTGSDL 625

  Fly   137 NNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAP------PL-------- 187
            :        :|:..|..       ::.|.|....|....|||..||.||      |:
Human   626 D--------SDVDSDPD-------KDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFF 675

  Fly   188 TPPQ-----------CSIPAV--------HPTLLEAMTKNL-PLQYRNVFA-GVLPG-------- 223
            .||.           .||.|:        .|..:....|.| .|.|.:.|. ..||.
Human   676 PPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPF 740

  Fly   224 ----------------------KVNSPAA-----------------------SSSPTGADFPF-- 241
                                  ||..|:|                       |:..:|.:.|.
Human   741 TDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDL 805

  Fly   242 --------------RHPLKK-----------------CELTWPPPTEQLQLELPHPNP------- 268
                          |.|.|.                 |....|   :|..|....|:|
Human   806 SIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMP---QQPPLHYAKPSPFFMDPIY 867

  Fly   269 --------------------KLSPVLPHPQLQDYQT---RRKNKARTAATGGNATPNLP------ 304
                                :.||:|.|||:...:|   :.::.|...|..|::...||
Human   868 SRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNF 932

  Fly   305 ------------QRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRH 357
                        ::.|:||||::|||:||||||||||||||||||||:||||:||||||||||||
Human   933 RSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH 997

  Fly   358 VRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFCENPT---- 418
            ||||||||:||||.:|.|||||||||||||||||.:...:|...||... | :.....:||
Human   998 VRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTN-H-LGTSASSPTSESD 1060

  Fly   419 --------EESYFEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCS---------- 465
                    |:|||.|||:|:......|...:.:::.|.|       ....|:.|.
Human  1061 NHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQ-------IVDGSAQCPGLASEKQEDV 1118

  Fly   466 SSRDTPTSSHEEADHAPATSTADTAAPS---SSRDQEEEDSQPIMEL 509
            ...|......::.|.....|..||.:|:   .:..::|||.:|...|
Human  1119 EEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASL 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	50/80 (63%)
		zf-C2H2	311..333	CDD:278523	18/21 (86%)
		C2H2 Zn finger	313..333	CDD:275368	16/19 (84%)
		zf-H2C2_2	325..349	CDD:290200	21/23 (91%)
		C2H2 Zn finger	341..362	CDD:275368	19/20 (95%)
		zf-H2C2_2	353..377	CDD:290200	19/23 (83%)
		zf-C2H2	368..390	CDD:278523	18/21 (86%)
		C2H2 Zn finger	370..390	CDD:275368	16/19 (84%)
PRDM16	NP_071397.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		SET	84..209	CDD:214614
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	295..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-C2H2	337..358	CDD:278523
		C2H2 Zn finger	339..357	CDD:275368
		zf-C2H2	366..388	CDD:278523
		C2H2 Zn finger	368..388	CDD:275368
		zf-C2H2_8	369..450	CDD:292531
		zf-C2H2	394..416	CDD:278523
		C2H2 Zn finger	396..416	CDD:275368
		C2H2 Zn finger	425..443	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..657		31/164 (19%)
		Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250\|UniProtKB:A2A935	679..1038		113/361 (31%)
		Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269\|PubMed:19049980	739..1276		132/439 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	772..804		3/31 (10%)
		COG5048	931..>1083	CDD:227381	88/153 (58%)
		zf-C2H2	951..973	CDD:278523	18/21 (86%)
		C2H2 Zn finger	953..973	CDD:275368	16/19 (84%)
		zf-H2C2_2	965..989	CDD:290200	21/23 (91%)
		zf-C2H2	979..1002	CDD:278523	20/22 (91%)
		C2H2 Zn finger	981..1002	CDD:275368	19/20 (95%)
		zf-C2H2	1008..1030	CDD:278523	18/21 (86%)
		C2H2 Zn finger	1010..1030	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1033..1065		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1163		11/57 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11260
eggNOG	1	0.900	-	-		E33208_3BAJ6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.880