DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF287

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001333096.1	Gene:	ZNF287 / 57336	HGNCID:	13502	Length:	761	Species:	Homo sapiens

Alignment Length:	193	Identity:	60/193 - (31%)
Similarity:	84/193 - (43%)	Gaps:	53/193 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LQYRNVFAGVLPGKVNSPAASSSPTGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLP 275
            ||::.:..|..|.|.|                    :|...:...|..::.:..|...|.
Human   524 LQHQKIHTGKKPYKCN--------------------ECWKVFSQSTYLIRHQRIHSGEKC----- 563

  Fly   276 HPQLQDYQTRRKNKA----------RTAATGGNATPNLPQRNKDRYTCKFCGKVFPRSANLTRHL 330
                  |:.....||          :|..||           :..|.|..|||.|.:|||||:|.
Human   564 ------YKCNECGKAFAHSSTLIQHQTTHTG-----------EKSYICNICGKAFSQSANLTQHH 611

  Fly   331 RTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESD 393
            ||||||:||||..|.::||.|.:|.:|.| |||.|:||||.||.:.:.|..||.:|.:.|..:
Human   612 RTHTGEKPYKCSVCGKAFSQSVHLTQHQR-IHNGEKPFKCNICGKAYRQGANLTQHQRIHTGE 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	30/62 (48%)
		zf-C2H2	311..333	CDD:278523	13/21 (62%)
		C2H2 Zn finger	313..333	CDD:275368	12/19 (63%)
		zf-H2C2_2	325..349	CDD:290200	15/23 (65%)
		C2H2 Zn finger	341..362	CDD:275368	8/20 (40%)
		zf-H2C2_2	353..377	CDD:290200	13/23 (57%)
		zf-C2H2	368..390	CDD:278523	9/21 (43%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
ZNF287	NP_001333096.1	SCAN	46..144	CDD:413396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..154
		KRAB	170..227	CDD:214630
		SFP1	<364..419	CDD:227516
		C2H2 Zn finger	370..390	CDD:275368
		C2H2 Zn finger	398..418	CDD:275368
		COG5048	422..755	CDD:227381	60/193 (31%)
		C2H2 Zn finger	426..446	CDD:275368
		C2H2 Zn finger	454..474	CDD:275368
		C2H2 Zn finger	482..502	CDD:275368
		C2H2 Zn finger	510..530	CDD:275368	2/5 (40%)
		C2H2 Zn finger	538..558	CDD:275368	3/39 (8%)
		C2H2 Zn finger	566..586	CDD:275368	3/19 (16%)
		C2H2 Zn finger	594..614	CDD:275368	12/19 (63%)
		C2H2 Zn finger	622..642	CDD:275368	8/20 (40%)
		C2H2 Zn finger	650..670	CDD:275368	7/19 (37%)
		C2H2 Zn finger	678..698	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	734..754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910