DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and ZNF630

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001032824.2	Gene:	ZNF630 / 57232	HGNCID:	28855	Length:	657	Species:	Homo sapiens

Alignment Length:	184	Identity:	57/184 - (30%)
Similarity:	84/184 - (45%)	Gaps:	34/184 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 YTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRHVRNIHNKERPFKCEICER 375
            |.|..|||.|.:.::||.|.|.||||:||.|..|.:|||..|.|..|.| ||..|:|::|..|.:
Human   459 YVCTDCGKAFSQKSHLTGHQRLHTGEKPYMCTECGKSFSQKSPLIIHQR-IHTGEKPYQCGECGK 522

  Fly   376 CFGQQTNLDRHLKKHESD----------AVSLSALSGVSERMHCIRRFCENPTEESYFEEIRSFM 430
            .|.|::.|..||:.|..:          |.||.:...:.:|.|.    .|.|.|.|  |..::|.
Human   523 TFSQKSLLIIHLRVHTGEKPYECTECGRAFSLKSHLILHQRGHT----GEKPYECS--ECGKAFC 581

  Fly   431 GK----VTQQQQQQQQ-------------QQQHDQQQQQHQSTATSASSSCSSS 467
            ||    :.|:...:::             :.|....|::|.....|..|.|..:
Human   582 GKSPLIIHQKTHPREKTPECAESGMTFFWKSQMITYQRRHTGEKPSRCSDCGKA 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	26/51 (51%)
		zf-C2H2	311..333	CDD:278523	10/21 (48%)
		C2H2 Zn finger	313..333	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	13/23 (57%)
		C2H2 Zn finger	341..362	CDD:275368	9/20 (45%)
		zf-H2C2_2	353..377	CDD:290200	9/23 (39%)
		zf-C2H2	368..390	CDD:278523	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
ZNF630	NP_001032824.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	238..257	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368
		C2H2 Zn finger	293..313	CDD:275368
		zf-H2C2_2	305..330	CDD:290200
		C2H2 Zn finger	321..341	CDD:275368
		COG5048	<329..578	CDD:227381	47/125 (38%)
		zf-H2C2_2	336..358	CDD:290200
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		zf-H2C2_2	389..412	CDD:290200
		C2H2 Zn finger	405..425	CDD:275368
		zf-H2C2_2	418..440	CDD:290200
		C2H2 Zn finger	433..453	CDD:275368
		zf-H2C2_2	449..470	CDD:290200	6/10 (60%)
		C2H2 Zn finger	461..481	CDD:275368	9/19 (47%)
		zf-H2C2_2	473..498	CDD:290200	14/24 (58%)
		C2H2 Zn finger	489..509	CDD:275368	9/20 (45%)
		zf-H2C2_2	502..526	CDD:290200	10/24 (42%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		zf-H2C2_2	530..553	CDD:290200	5/22 (23%)
		C2H2 Zn finger	545..565	CDD:275368	4/19 (21%)
		zf-H2C2_2	557..580	CDD:290200	7/28 (25%)
		C2H2 Zn finger	573..593	CDD:275368	6/21 (29%)
		C2H2 Zn finger	601..620	CDD:275370	2/18 (11%)
		C2H2 Zn finger	629..646	CDD:275368	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910