DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10348 and klf4

DIOPT Version :9

Sequence 1:NP_001286059.1 Gene:CG10348 / 35132 FlyBaseID:FBgn0032707 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_001106955.1 Gene:klf4 / 562155 ZFINID:ZDB-GENE-111014-1 Length:396 Species:Danio rerio


Alignment Length:421 Identity:97/421 - (23%)
Similarity:140/421 - (33%) Gaps:143/421 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 VYPALGLIPTSYISHVPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQHQTLNHHAKG 84
            |.|.:..|....:..:.||...|.|:                    ||.|...|...:....|..
Zfish    68 VPPVMAKIEPEELELLDYDFILSNSL--------------------LQQQQQQQASTSRTIPASS 112

  Fly    85 KRRSSFDQPLDLRLAHKRKTDLVDQGPMEDENSNLI-----------------MFASELAVAQQK 132
            ....:|..|                .|...|.|.|.                 :...||..|..:
Zfish   113 PTHYTFPMP----------------SPQGQEGSMLYTIPDISDVSPSGGFVAELMRPELDPAYLQ 161

  Fly   133 EKELNNNHIAASLADL-----GFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAPPLTPPQC 192
            ...|:...:..:..|:     |..:|:                      .....|.|.|....:|
Zfish   162 PTSLHGKFVVKTTMDMSDYNQGVSISK----------------------DASAVPFACPRIKQEC 204

  Fly   193 SIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSPTGAD---FPFRHPLKKCELTWPP 254
              |:   |...:...:|.|:..:..:||..|.:..|.|.||..||.   .|..||          
Zfish   205 --PS---TCTASRPMDLHLRGSSAQSGVHQGSMLDPHAFSSGRGARSSLSPDEHP---------- 254

  Fly   255 PTEQLQLELP------HPNPKLS--PVLPHPQLQDYQTRRKNKARTAATGGNATPNLPQRNKDR- 310
                   :.|      |||...|  |..|...|| ||     :..:.|.|      ||:.:|.: 
Zfish   255 -------QAPGLGSGYHPNTAYSGFPQAPAQSLQ-YQ-----ELISPAEG------LPEESKPKR 300

  Fly   311 ------------YTCKF--CGKVFPRSANLTRHLRTHTGEQPYKCKY--CERSFSISSNLQRHVR 359
                        :||.:  |||.:.:|::|..|.||||||:||.|.:  |...|:.|..|.||.|
Zfish   301 GRRSWPRKRIATHTCDYAGCGKTYTKSSHLKAHHRTHTGEKPYHCDWEGCGWKFARSDELTRHYR 365

  Fly   360 NIHNKERPFKCEICERCFGQQTNLDRHLKKH 390
            . |...|||:|..|:|.|.:..:|..|:|:|
Zfish   366 K-HTGIRPFQCLKCDRAFSRSDHLALHMKRH 395

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10348NP_001286059.1 COG5048 300..>363 CDD:227381 27/79 (34%)
zf-C2H2 311..333 CDD:278523 9/23 (39%)
C2H2 Zn finger 313..333 CDD:275368 8/21 (38%)
zf-H2C2_2 325..349 CDD:290200 12/25 (48%)
C2H2 Zn finger 341..362 CDD:275368 8/22 (36%)
zf-H2C2_2 353..377 CDD:290200 11/23 (48%)
zf-C2H2 368..390 CDD:278523 8/21 (38%)
C2H2 Zn finger 370..390 CDD:275368 7/19 (37%)
klf4NP_001106955.1 zf-C2H2 313..337 CDD:278523 9/23 (39%)
C2H2 Zn finger 315..337 CDD:275368 8/21 (38%)
COG5048 <320..>375 CDD:227381 26/55 (47%)
C2H2 Zn finger 345..367 CDD:275368 8/22 (36%)
zf-H2C2_2 359..384 CDD:290200 12/25 (48%)
C2H2 Zn finger 375..395 CDD:275368 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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